A5041818582- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Neuroscience and Neural Engineering
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- CRISPR and Genetic Engineering
- Corneal surgery and disorders
- Ocular Disorders and Treatments
- Photoreceptor and optogenetics research
- Retinoids in leukemia and cellular processes
- Virus-based gene therapy research
- Cardiovascular Syncope and Autonomic Disorders
- Head and Neck Surgical Oncology
- Retinal and Optic Conditions
- Pluripotent Stem Cells Research
- Literacy and Educational Practices
- Clinical practice guidelines implementation
- Neuropeptides and Animal Physiology
- Meningioma and schwannoma management
- RNA regulation and disease
- Brain Metastases and Treatment
Hospital Universitario Virgen Macarena
2016-2024
Instituto de Salud Carlos III
2019-2022
Ministry of Health
2019
Universidad de Sevilla
2019
Andalusian Health Service
2016-2018
Penn Presbyterian Medical Center
1987
University of Pennsylvania
1987
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) ocular hypertension (OHT) after initial repeated administrations.Randomized, 20-month, multicenter, subject- evaluator-masked, parallel-group, phase 3 clinical study.Adults OAG or OHT each eye, open iridocorneal angle inferiorly study eye baseline IOP (hour 0; 8 am) 22-32 mmHg washout.Study eyes received 10 μg (n = 198) 15 on day 1...
Background: To characterize the phenotype and genotype of a rare syndrome associating posterior microphthalmos (PM), retinitis pigmentosa (RP), foveoschisis in consanguineous Spanish family.Methods: The study involved five family members, consisting three siblings their parents. All members underwent comprehensive eye examinations for best corrected visual acuity, axial length refractive error, electroretinography (ERG), fundus photography, retinal fluorescein angiography (FA), optical...
Currently, brachytherapy is the most commonly used therapeutic approach for uveal melanomas. Surgical resection by means of endoresection or exoresection an alternative approach. The present report recounts our experience over 15 years in treatment melanoma using a combined surgery with brachytherapy. This single-center observational retrospective cohort study which we describe clinical outcomes, complications and survival 35 cases iris ciliary body after combination alone. Local tumor was...
Retinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal recessive RP. The human iPS cell line, CABi002-A, derived from peripheral blood mononuclear cells a patient carrying heterozygous double mutation gene was generated by non-integrative reprogramming technology, using hOCT3/4, hSOX2, hc-MYC and hKLF4 factors. Pluripotency differentiation capacity were assessed immunocytochemistry RT-PCR. This iPSC line can be further...
Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and characterized by progressive macula, central region retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) a patient with clinical diagnosis dry AMD carrying CFH Y402H polymorphism. Sendai virus using for reprogramming differentiation capacity were assessed immunocytochemistry RT-PCR.
Retinal dystrophies associated to mutations in the CRB1 gene comprise a wide array of clinical presentations. A blood sample from patient with family history CRB1-retinal dystrophy was used prepare iPSC line ESi082-A. The genotype donor, affected perifoveal-bilateral macular includes one frameshift deletion and hypomorphic allele. ESi082-A cell has been characterized for pluripotency will be retinal cellular models study dysfunction leading disease.
To describe the clinical and genetic characteristics (novel mutation in BEST1 gene) of a Spanish patient with autosomal recessive bestrophinopathy (ARB).The detailed ophthalmological examination included best corrected visual acuity (BCVA), color autofluorescence photography, fluorescein angiography, optical coherence tomography, electrophysiology tests. A next-generation sequencing (NGS) strategy was applied to index patient, then sequenced an Illumina NextSeq500 system.A 55-year-old male...
PRPF31 gene codes for a ubiquitously expressed splicing factor but mutations affect exclusively the retina, producing progressive death of photoreceptor cells. We have identified novel mutation in patient with autosomal dominant retinitis pigmentosa. A blood sample was obtained and mononuclear cells were reprogrammed using non-integrative Sendai virus to generate cell line CABi001-A. The iPSC has been characterized pluripotency differentiation capacity will be differentiated toward...