Sayoko E. Moroi
A5090443674- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Receptor Mechanisms and Signaling
- Ocular Disorders and Treatments
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Health Research
- Cerebral Venous Sinus Thrombosis
- Connective tissue disorders research
- Retinal and Macular Surgery
- Connexins and lens biology
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Ocular Oncology and Treatments
- Proteoglycans and glycosaminoglycans research
- Nicotinic Acetylcholine Receptors Study
University of Michigan
2015-2025
The Ohio State University
1988-2025
The Ohio State University Wexner Medical Center
2020-2025
Michigan Medicine
2002-2022
Michigan United
2011-2020
W.K. Kellogg Foundation
1999-2019
GTx (United States)
2019
Visual Sciences (United States)
2018-2019
Massachusetts Eye and Ear Infirmary
2012
Harvard University
2012
Age-related macular degeneration (AMD) is a genetically heterogeneous disease that leads to progressive and irreversible vision loss among the elderly. Inflammation, oxidative damage, cholesterol metabolism and/or impaired function of retinal pigment epithelium (RPE) have been implicated in AMD pathogenesis. We examined toll-like receptor 4 (TLR4) as candidate gene for susceptibility because: (i) TLR4 located on chromosome 9q32–33, region exhibiting evidence linkage three independent...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is complex disease with significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls replication the most findings in 9173 26 780 across 18 collections Asian, African European descent. Apart from confirming strong evidence association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P 2.81 × 10−33), we observed one SNP showing to (CDC7–TGFBR3 rs1192415,...
Glaucoma is a leading cause of blindness worldwide. Primary open-angle glaucoma (POAG) the most common subtype and complex trait with multigenic inheritance. Genome-wide association studies have previously identified significant between POAG SIX6 locus (rs10483727, odds ratio (OR) = 1.32, p 3.87×10−11). plays role in ocular development has been associated morphology optic nerve. We sequenced coding regulatory regions 262 cases 256 controls six nonsynonymous variants, including five rare one...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) ocular hypertension (OHT) after initial repeated administrations.Randomized, 20-month, multicenter, subject- evaluator-masked, parallel-group, phase 3 clinical study.Adults OAG or OHT each eye, open iridocorneal angle inferiorly study eye baseline IOP (hour 0; 8 am) 22-32 mmHg washout.Study eyes received 10 μg (n = 198) 15 on day 1...
PurposeTo compare the ocular hypotensive efficacy and safety of a fixed-dose combination (FDC) Rho kinase inhibitor netarsudil latanoprost vs monotherapy with or latanoprost.DesignThree-month primary endpoint analysis randomized, double-masked, phase 3 clinical trial.MethodsAdults open-angle glaucoma hypertension (unmedicated intraocular pressure [IOP] >20 <36 mm Hg at 8:00 AM) were randomized to receive once-daily netarsudil/latanoprost FDC, 0.02%, 0.005% for up 12 months. The was mean IOP...
purpose. To identify the gene responsible for a complex ocular phenotype of late-onset macular degeneration, long anterior zonules (LAZ), and elevated intraocular pressure (IOP) to study its expression. methods. Ocular examination, visual field, fluorescein angiography, electrophysiology testing were performed. One affected individual was treated with vitamin A. DNA from 55 family members (UM:H389) used linkage, mapping, mutation analysis. Linkage analysis degeneration LAZ phenotypes...
In Brief Purpose: To evaluate the results and complications of cataract surgery in patients with nanophthalmos. Setting: University hospital practice. Methods: The records consecutive nanophthalmos who had from 1978 through 2002 were reviewed for ocular diagnoses, corneal diameter, keratometry, axial length, retinal–choroidal–scleral thickness determined by echography, surgeries, visual acuity, complications. Results: Eight (6 women, 2 men) a mean age 59 years reviewed. Four not previously...
To evaluate outcomes of the Boston type I keratoprosthesis (KPro) and associated incidence glaucoma.Retrospective cohort study.All patients who underwent KPro surgery at 1 institution from 2003 to 2009 with least 3 months follow-up.Preoperative visual acuity, diagnosis, history glaucoma, intraoperative postoperative parameters were recorded. Statistical analysis was performed identify factors that may influence increase in intraocular pressure (IOP) glaucoma development or progression after...