A5067804224- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Hallucinations in medical conditions
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Impairment Studies
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Historical Art and Architecture Studies
- Retinopathy of Prematurity Studies
- History of Medicine Studies
- Optical Coherence Tomography Applications
- Retinal and Macular Surgery
- Drug-Induced Ocular Toxicity
- Ocular Oncology and Treatments
- Complementary and Alternative Medicine Studies
- Ophthalmology and Visual Health Research
- Systemic Lupus Erythematosus Research
Hospital Clínico San Carlos
2016-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2016-2025
Universidad Complutense de Madrid
2016-2025
Instituto Ramón y Cajal de Investigación Sanitaria
1997-2025
Smith-Kettlewell Eye Research Institute
2023-2025
Stanford University
2023-2025
Instituto de Salud Carlos III
2015-2024
Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes
2024
University of Alicante
2023
Comunidad de Madrid
2021
The objective of the present study was to determine whether dry eye (DE) associated with primary Sjögren's syndrome (PSDE) and DE not (NSDE) are related an alteration corneal innervation.Eleven healthy volunteers younger than 60 years (normal [N] < group), 10 age or older (N > = 11 patients PSDE, NSDE were studied. Epithelial stromal density subbasal nerves investigated by confocal microscopy.The superficial epithelial cells 741 +/- 306 cells/mm2 in PSDE group; 1022 331 1523 294 N group,...
To establish the reproducibility of a rebound tonometer in humans and effect corneal thickness on measurements, comparing it with Goldmann applanation tonometer.In first study designed to examine reliability RBT, three experienced ophthalmologists undertook consecutive intraocular pressure (IOP) measurements 12 eyes normal subjects. A cross-sectional was then performed compare obtained using two tonometers 147 85 patients ocular hypertension or glaucoma.Intraobserver coefficients correlation...
Micro-invasive glaucoma surgical implantation of trabecular micro-bypass stents, previously shown to be safe and effective for open-angle (OAG) subjects during cataract surgery, was considered evaluation as a sole procedure. The aim this study evaluate the safety intraocular pressure (IOP)-lowering efficacy after ab interno two Glaukos Trabecular Micro-Bypass iStent inject second generation devices in with OAG. This performed at sites France, Germany, Italy, Republic Armenia, Spain. In...
To evaluate the long-term efficacy and safety of combined cataract surgery Glaukos iStent implantation for coexistent open-angle glaucoma cataract.Prospective, non-comparative, uncontrolled, non-randomised, interventional case series study. Subjects older than 18 years with uncontrolled mild or moderate (including pseudoexfoliative pigmentary) underwent phacoemulsification intraocular lens along ab-interno gonioscopically guided one iStent. The variables recorded during a minimum 3 follow-up...
PURPOSE. To evaluate the changes in aqueous humor dynamics and efficacy safety of iStent (Glaukos Corp., Laguna Hills, CA), combination with cataract surgery. METHODS. This investigation was a prospective, randomized, clinical study patients open-angle glaucoma or ocular hypertension who were undergoing Aqueous flow (F) trabecular outflow facility (C(T)) measured by fluorophotometry before surgery at months 1, 6, 12 both groups. RESULTS. Thirty-three eyes 33 randomized to either two stents...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) ocular hypertension (OHT) after initial repeated administrations.Randomized, 20-month, multicenter, subject- evaluator-masked, parallel-group, phase 3 clinical study.Adults OAG or OHT each eye, open iridocorneal angle inferiorly study eye baseline IOP (hour 0; 8 am) 22-32 mmHg washout.Study eyes received 10 μg (n = 198) 15 on day 1...
To assess the safety and effectiveness of PRESERFLO® MicroShunt (formerly InnFocus MicroShunt) in patients with primary open-angle glaucoma (POAG).The MicroShunt, a controlled ab externo filtration surgery device, was investigated 2-year, multicenter, single-arm study.Eligible were aged 18-85 years POAG inadequately on maximal tolerated medical therapy intraocular pressure (IOP) ≥18 ≤35 mmHg or when progression warranted surgery.The implanted as stand-alone procedure adjunctive use topical...
The main purpose of this study is to evaluate the presence viral RNA severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in conjunctival swab specimen coronavirus disease 2019 (COVID-19) patients with and without conjunctivitis establish diagnostic value reverse transcription-polymerase chain reaction (RT-PCR) each case describe its clinical characteristics. A cross-sectional was conducted at Hospital Clinico San Carlos Madrid, Spain. Thirty-six subjects from COVID admission unit...
The purpose of this study was to evaluate the frequency and clinical presentation conjunctivitis in hospitalized patients with COVID-19.A cross-sectional conducted at Hospital Clinico San Carlos Madrid, Spain. A total 301 subjects from COVID admission unit laboratory-confirmed SARS-CoV-2 infection were included. presence characteristics evaluated. Laboratory, radiological, results without stratified by sex analyzed.Of included, 180 (59.8%) male median age 72 years (IQ 59-82). Overall, 35...
PROLOGUE:
PurposeTo compare the effectiveness and safety of MicroShunt (Santen Inc., Emeryville, CA, USA) versus trabeculectomy in patients with primary open-angle glaucoma (POAG).DesignProspective, randomized, multicenter trial conducted United States Europe.ParticipantsAdult (aged 40-85 years) mild to severe POAG inadequately controlled on maximum tolerated medical therapy intraocular pressure (IOP) ≥15 mmHg ≤40 mmHg.MethodsPatients were randomized 3:1 standalone implantation (n=395) or (n=132),...
Purpose: Defocus Incorporated Multiple Segments (DIMS) lenses and atropine have proven standalone efficacy in controlling myopia progression children. However, there is a scarcity of evidence their when used combination. This randomized controlled trial (RCT) aims to evaluate the combination treatment using 0.025% DIMS spectacle compared single vision (SV) slowing European myopic Methods: RCT conducted on children aged 4‐16 years with between ‐1.00 ‐6.00D astigmatism ≤2.00D. Children were...
Abstract Background/Objectives To evaluate the efficacy and safety of preservative-free latanoprost eye drop emulsion in reducing intraocular pressure (IOP) versus preserved open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods A Phase III non-inferiority study randomised patients with OAG/OHT 1:1 to receive latanoprost. The primary endpoint was change from baseline peak (9:00 A.M. ± 1 h) trough (4:00 P.M. IOP at Week 12 (non-inferiority margin: 95% confidence interval for...
Purpose. To evaluate tear secretion and corneal sensitivity after laser in situ keratomileusis (LASIK) for the correction of myopia. Methods. In a prospective study, 48 consecutive eyes (24 patients) underwent LASIK to correct myopia ranging from −3.5 −12.25 diopters. Tear tested by function index using Cochet-Bonnet esthesiometer were evaluated preoperatively 1 week 1, 3, 6, 9 months postoperatively. Results. reduced during first 3 surgery (p < 0.001). returned its preoperative values only...
To establish correlations between intraocular pressure (IOP) measurements obtained with the ocular response analyzer (ORA) and Goldmann applanation tonometer (GAT). The effects of central corneal thickness on measures were also examined.This was a cross-sectional study. IOP determined in 48 eyes patients glaucoma In all patients, (CCT) measured by ultrasound pachymetry.ORA readings consistently higher than GAT (Goldmann-correlated - mean difference, 7.2 +/- 3.5 mm Hg; corneal-compensated 8.3...
PurposeTo evaluate the safety and efficacy of iStent Trabecular Micro-bypass Stent in patients undergoing concurrent cataract glaucoma surgery.MethodsProspective, 24-month, uncontrolled, multicenter, multicountry evaluation 58 with uncontrolled primary open-angle (including pseudoexfoliation pigmentary) cataract. Patients underwent clear cornea phacoemulsification followed by ab interno gonioscopically guided implantation iStent. Of 48 per protocol population, 42 completed 12 months 24-month...