A5019049183- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Syncope and Autonomic Disorders
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Ocular Oncology and Treatments
- Venous Thromboembolism Diagnosis and Management
- Medical and Biological Sciences
- Sinusitis and nasal conditions
- Retinal Development and Disorders
- Clinical practice guidelines implementation
- Head and Neck Surgical Oncology
- Retinopathy of Prematurity Studies
- Proteoglycans and glycosaminoglycans research
Johns Hopkins University
2013-2022
National Eye Institute
2002-2022
Johns Hopkins Medicine
2012-2022
Faculty of 1000 (United States)
2021
RELX Group (United States)
2021
University of Baltimore
2010-2020
Barro Colorado Island
2020
Sunnybrook Health Science Centre
2020
Health Sciences Centre
2020
University of Toronto
2020
Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the release of angiogenic molecules. Vascular endothelial growth factor (VEGF) is an endothelial-cell-specific whose production increased hypoxia.
The transforming growth factor-βs are peptide factors known to play a central role in wound healing. Using specific, vitro assay of cell inhibition, we have detected factor-β (TGF-β) 24/24 aqueous humor specimens from eyes undergoing cataract extraction with intraocular lens implantation. amount TGF-β ranged 2.3 8.1 ng/ml (mean ± SD = 4.5 1.7 ng/ml), 61% present the active form.Subtyping was performed by addition antibodies specific for ß1 and ß2 isoforms inhibition assay, confirmed sandwich...
The posterior pole ganglion cell bodies form a substantial fraction of the retinal thickness, prompting authors to study feasibility detecting, by scanning thickness analysis, changes at due glaucomatous damage.Nonconsecutive case series.One or both eyes patients with chronic open-angle glaucoma who presented either superoinferior asymmetry in visual fields localized field loss nerve fiber layer defect visible on photography were recruited. Twenty-nine 18 studied.A laser slit was projected...
Purpose: The purpose of this study is to determine why a single intraoperative dose mitomycin C (MMC) appears promote the success glaucoma filtration surgery. Methods: Human Tenon's capsule fibroblasts were exposed MMC and 5-fluorouracil (5-FU) in vitro at concentrations durations exposure used clinically. Cell proliferation was assessed by quantification 3H-thymidine uptake. viability studied using sulfarhodamine B cell protein stain trypan blue exclusion. Results: Neither (0.4 mg/ml) nor...
Objective: To examine resource consumption and the direct costs of treating glaucoma at different disease severity levels.Design: Observational, retrospective cohort study based on medical record review.Participants: One hundred fifty-one records patients with primary open-angle or normal-tension glaucoma, suspect, ocular hypertension (age Ն18 years) were randomly selected from 12 sites in United States stratified according to International Classification Diseases, Ninth Revision, Clinical...
To determine how glaucoma patients with various degrees of vision loss rate their vision, and to if the Esterman binocular visual field test other function tests correlate those ratings.Two hundred thirty-seven evaluated using 2 utility tests, linear rating scale time trade-off test, quality-of-life instruments, National Eye Institute Visual Function Questionnaire (VFQ) Short Form 36 (SF-36). Their results were compared clinical persons normal (n = 12) blind 12).On a 0 (blind) 100 (ideal),...
Purpose To estimate the change in iris cross-sectional (CS) area with pupil dilation using anterior segment optical coherence tomography comparing eyes angle closure (AC) to open glaucoma (OAG). Methods Sixty-five patients from Wilmer Glaucoma service, 36 definite or suspected OAG and 29 AC, underwent imaging under 3 conditions (pupil constriction light, physiologic dark, after pharmacologic dilation). The nasal temporal CS areas were measured custom software, times each of 4 meridians....