A5042154323- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Cerebral Venous Sinus Thrombosis
- Retinal and Macular Surgery
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Retinopathy of Prematurity Studies
- Proteoglycans and glycosaminoglycans research
- Connective tissue disorders research
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Corneal Surgery and Treatments
- Ocular Oncology and Treatments
- Ocular and Laser Science Research
- Cellular Mechanics and Interactions
- Optical Imaging and Spectroscopy Techniques
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
Johns Hopkins Hospital
2001-2023
Ophthalmology Associates (United States)
2009-2023
National Eye Institute
2008-2020
University of Baltimore
1998-2019
Carl Zeiss (Germany)
2013
Dana (United States)
1995-2009
Southern California Eye Institute
2009
Glaucoma Research Foundation
1980-2008
Aim: To estimate the number of people with open angle (OAG) and closure glaucoma (ACG) in 2010 2020. Methods: A review published data use prevalence models. Data from population based studies age specific OAG ACG that satisfied standard definitions were used to construct models for by age, sex, ethnicity, weighting proportional sample size each study. Models combined UN world projections 2020 derive estimated glaucoma. Results: There will be 60.5 million 2010, increasing 79.6 2020, these,...
We examined the histologic structure of optic nerve head in 15 eyes nine persons with a known glaucoma history. All had been seeing eyes, varying from normal visual acuity and field to advanced damage. The site damage fibers is scleral lamina cribrosa, where there local blockage axonal transport. Early cup size increase prior definite loss results fibers, not astrocytic glial cells head. No selective capillaries seen mildly damaged specimens. Scanning electron microscopic analysis suggests...
• The number and distribution of human optic nerve axons were compared with clinical measurements available in the same eyes, including visual acuity, disc appearance, field studies. Definite loss occurs prior to reproducible defects some patients suspected having glaucoma. In glaucoma, superior inferior poles lose fibers at a selectively greater rate, leading an hourglass-shaped atrophy. Cavernous degeneration retrobulbar is rarely observed chronic pattern atrophy examples toxic amblyopia,...
Standardized perimetry and nerve fiber layer color fundus photography were performed annually on 1344 eyes with elevated intraocular pressures. In 83 eyes, glaucomatous field defects developed that met rigid criteria manual kinetic suprathreshold static perimetry. Individual photographs read by two masked observers. The more sensitive of the identified in 88% readable at time loss first occurred; 60% (6/10) already had 6 years before loss. contrast, was considered abnormal only 11% (3/27)...
Bilateral blindness unrelated to simple refractive error is twice as prevalent among blacks whites, although the difference narrows elderly. The reasons for this race- and age-related pattern are uncertain.
Previously, there was no feature of optic nerve head anatomy or physiology that could explain the greater susceptibility for early damage in some fibers by chronic glaucoma. Using a new technique scanning electron microscopic examination human heads, regional differences were found fine structure lamina cribrosa. The superior and inferior parts at level sclera appear to contain larger pores thinner connective tissue support passage nerve-fiber bundles than nasal temporal lamina. Since...
To evaluate the association of vascular factors with primary open-angle glaucoma (POAG).A population-based prevalence survey ocular disease among black and white residents.Communities east Baltimore, Md.A stratified cluster sample 5308 residents 40 years age or older.Primary as defined by demonstrable glaucomatous optic nerve damage based on visual fields and/or disc findings. Intraocular pressure level was not a criterion for diagnosis.Systolic diastolic blood showed modest, positive POAG....
From annual examinations of 813 ocular hypertensive eyes, the authors compared optic disc and nerve fiber layer photographs in 2 age-matched subgroups: 37 eyes that converted to abnormal visual field tests at end a 5-year period control retained normal tests. Disc change was detected only 7 (19%) converters loss 1 (3%) controls. Progressive atrophy observed 18 (49%) 3 (8%) Serial examination more sensitive than color evaluation detection progressive glaucoma damage this early stage glaucoma....
Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter optic nerve fibers. In some eyes, automated perimetry had been performed. Optic fibers larger than mean killed more rapidly smaller fibers, although no fiber size was completely spared at any stage atrophy. The varies considerably among normal eyes. authors confirmed that death a substantial proportion precedes detectable visual field loss.
• Tissues from six functioning and four failed filtering blebs in glaucomatous eyes examined by light electron microscopy showed normal epithelium. The response of the subepithelial connective tissue differed two groups. Failed had dense collagenous their walls. In blebs, was loosely arranged contained histologically clear spaces. These spaces corresponded size position to microcystic seen clinically blebs. presence visible slit-lamp examination is probably a good sign bleb function.