A5017545268- Oral microbiology and periodontitis research
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Dental Health and Care Utilization
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Cancer, Lipids, and Metabolism
- HIV/AIDS oral health manifestations
- Silymarin and Mushroom Poisoning
- Streptococcal Infections and Treatments
- Ocular Surface and Contact Lens
- Healthcare and Venom Research
- Corneal surgery and disorders
- Salivary Gland Disorders and Functions
- Dental Anxiety and Anesthesia Techniques
- Immune Response and Inflammation
- Mechanisms of cancer metastasis
- Retinal and Optic Conditions
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Corneal Surgery and Treatments
- 3D Printing in Biomedical Research
- Multiple Sclerosis Research Studies
Technische Universität Dresden
2016-2025
University Hospital Carl Gustav Carus
2014-2025
Johannes Gutenberg University Mainz
2025
Heidelberg University
2004-2016
University Hospital Heidelberg
2004-2016
In-Q-Tel
2016
Heidelberg University
2005
PurposeTo evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired innervation.DesignPhase II multicenter, randomized, double-masked, vehicle-controlled trial.ParticipantsPatients with stage 2 (moderate) or 3 (severe) NK in 1 eye.MethodsThe REPARO phase study assessed 156 patients randomized 1:1:1 to rhNGF 10 μg/ml, 20 vehicle. Treatment...
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1Mastropasqua L. Massaro-Giordano G. Nubile M. Sacchetti Understanding the pathogenesis of neurotrophic keratitis: role nerves.J Cell Physiol. 2017; 232: 717-724Crossref PubMed Scopus (83) Google Scholar Because NK pathology involves trigeminal nerve damage and loss innervation, growth factor (NGF) is surmised to promote healing NK.2Lambiase A. Mantelli F. et al.Clinical...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 OAG OHT an open iridocorneal angle inferiorly study eye. Study eyes were administered on day 1, week 16, 32, twice-daily topical timolol maleate 0.5%. Primary endpoints IOP change from baseline through 12. Safety measures...
Severe periodontitis affects about 10% of the world population. In addition, associations between and systemic diseases exist. Therefore, diagnosis should be made quickly at an early stage. Matrix metalloproteinase-8 (MMP-8) is most prominent collagenase found in inflamed periodontal tissues. Its active form (aMMP-8) increasingly used as a diagnostic biomarker. Aim present study to evaluate accuracy novel aMMP-8 point-of-care (POC) test comparison standard laboratory diagnose disease rapidly...
To explore whether adjunctive antibiotics can relevantly influence long-term microbiota changes in stage III-IV periodontitis patients.This is a secondary analysis of randomized clinical trial on periodontal therapy with 500 mg amoxicillin and 400 metronidazole or placebo thrice daily for 7 days. Subgingival plaque samples were taken before 2, 8, 14 26 months after mechanical therapy. The V4-hypervariable region the 16S rRNA gene was sequenced Illumina MiSeq 250 base pair paired-end reads....
Abstract Objectives: The aim of this experimental gingivitis study was to assess the efficacy and safety two new chlorhexidine (CHX) mouthrinses. Materials Methods: Ninety volunteers participated in investigator‐blind, randomized, clinical‐controlled trial parallel groups. During treatment period, no oral hygiene measures except rinsing with non‐alcoholic 0.2% CHX or CHX/0.055% sodium fluoride mouthrinses, a positive control, negative control were permitted. primary parameter gingival index;...
Kraft‐Neumärker M, Lorenz K, Koch R, Hoffmann T, Mäntylä P, Sorsa Netuschil L. Full‐mouth profile of active MMP‐8 in periodontitis patients. J Periodont Res 2012; 47: 121–128. © 2011 John Wiley & Sons A/S Background and Objective: gingival crevicular fluid is considered as a protease with high destructive potential because its ability to degrade collagen periodontitis‐affected The aim this study was investigate whether there relationship between clinical diagnostic parameters the...
Background and Objective Matrix metalloproteinase‐8 ( MMP ‐8) is involved in a wide range of pathologies including periodontitis cardiovascular diseases CVD ). The association between has been repeatedly recognized. aim the study was to analyze what extent circulating active ‐8 aMMP associated with periodontal disease status oral fluid levels otherwise healthy subjects. Material Methods In cross‐sectional study, measured serum 59 volunteers, comprising 19 periodontally subjects, 20 patients...
Introduction . Periodontitis is an inflammatory process in response to dental biofilm and leads periodontal tissue destruction. The aim of this study was the comparison outcomes using either enamel matrix derivative (EMD) or a nanocrystalline hydroxyapatite (NHA) regenerative therapy after 6 12 months. Methods Using parallel group, prospective randomized design, we enrolled 19 patients each group. primary outcome bone fill Attachment gain, probing pocket depth (PPD) reduction, recession were...
Erythropoietin (EPO) is a candidate neuroprotective drug. We assessed its long-term safety and efficacy as an adjunct to methylprednisolone in patients with optic neuritis focused on conversions multiple sclerosis (MS).The TONE trial randomized 108 acute but without previously known MS either 33,000 IU EPO or placebo conjunction 1,000 mg daily for 3 days. After reaching the primary end point at 6 months, we conducted open-label follow-up 2 years after randomization.The was attended by 83 of...
Abstract Background/Objectives To evaluate the efficacy and safety of preservative-free latanoprost eye drop emulsion in reducing intraocular pressure (IOP) versus preserved open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods A Phase III non-inferiority study randomised patients with OAG/OHT 1:1 to receive latanoprost. The primary endpoint was change from baseline peak (9:00 A.M. ± 1 h) trough (4:00 P.M. IOP at Week 12 (non-inferiority margin: 95% confidence interval for...
Purpose To compare visual performance of the Vivinex Impress enhanced monofocal intraocular lens (IOL) (HOYA Surgical Optics) with Acrysof IQ IOL (Alcon Laboratories, Inc). Methods In this multicenter, active-controlled trial, participants were randomized 2:1 to bilateral implantation (test) or standard (control) and examined through 12 months postoperatively for acuities, refractive outcomes, defocus curves, pupil diameters. Results Ninety-eight test 46 control completed testing first...
Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) subsequent maintenance in Caucasian population. Analyses were performed using blood samples from periodontitis patients multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms analyzed...
Abstract Aim Assessment of treatment response after systemic amoxicillin/metronidazole adjunctive to subgingival instrumentation (SI) according stages and grades the 2018 classification periodontal diseases. Materials Methods We carried out exploratory re‐analysis placebo‐controlled, multi‐centre ABPARO trial (52; 45/60 years age; 205 males, 114 active smokers). Patients were randomized SI with amoxicillin 500 mg/metronidazole 400 mg (three times a day for 7 days, n = 205; ANTI) or placebo (...
Polymeric materials such as biodegradable polycaprolactone (PCL) have garnered significant attention for their utility in biomedical applications. With its notable low glass transition temperature (Tg), PCL exhibits flexibility at physiological temperatures, rendering it an ideal candidate drug delivery systems, particularly fibrous form. This suitability is pronounced when these fibres are designed placement within periodontal pockets resulting from periodontitis. However, the degradation...
<title>Abstract</title> As a "simple phobia", dental phobia is often dismissed as harmless anxiety disorder and relegated to the domain of dentists, who can treat diseases but not disorder. The subjective burden patients with indicated by numerous studies showing reduced oral health-related quality life (OHRQL). We aimed assess biopsychosocial consequences from objective manifestations previously unknown effects on satisfaction. In our cross-sectional study, 61 phobic 69 age-matched...
Common antibiotic therapies to treat bacterial infections are associated with systemic side effects and the development of resistance, directly connected duration dosage. Local drug delivery systems (DDSs) offer an alternative by localising antibiotics thereby limiting their while reducing dosage necessary. A biodegradable polyester polycaprolactone (PCL)-based DDS was thus produced, containing various clinically relevant drugs. It shown that incorporation four distinct classes (amoxicillin,...
Abstract Aim: We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants in pathogen‐recognition receptor Toll‐like 4 (TLR4) and promoter region pro‐inflammatory cytokine interleukin‐18 (IL‐18). Material Methods: One hundred eleven patients 80 periodontally healthy controls were genotyped for four TLR4 gene (c.896A>G c.1196C>T) IL‐18 (c.−368G>C c.−838C>A). The genotype allele...
The aim of the study was to assess whether genotypes in Toll-like receptor 4 gene and promoter interleukin-18 are associated with susceptibility chronic periodontitis. 108 periodontitis patients 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) c.-368G>C/ c.-838C>A (IL-18 promoter).There no significant differences genotype allele distributions between groups. Periodontitis severity TLR4 c.896AG/1196CT significantly higher than wildtype carriers. percentage teeth clinical attachment...
Extracorporeal photopheresis (ECP) constitutes a promising treatment for patients with steroid-refractory acute graft-versus-host disease (aGvHD) after allogeneic stem cell transplantation and graft rejection solid organ (SOT). There is an increasing body of evidence that modulation lymphocyte subsets might play crucial role in the mechanism action ECP. We therefore analyzed immunological effects concomitantly clinical findings under ECP therapy using multicolor flow cytometry. In patient...
Periodontitis is a highly prevalent multifactorial disease associated with various mental disorders. However, study results about this association are still contradictory. One methodological reason could be the neglect of potential confounders, such as socioeconomic factors or comorbidity. Our examined wide range psychosocial risk indicators to identify those relevant associations periodontitis.In cross-sectional study, 111 patients periodontitis (PERIO) (> 30% teeth approximal attachment...