A5063413978- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Cancer-related Molecular Pathways
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Occupational and environmental lung diseases
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Cancer Diagnosis and Treatment
Ruhr University Bochum
2016-2025
BG University Hospital Bergmannsheil Bochum
2015-2025
Technische Hochschule Georg Agricola
2014-2025
St. Marien Hospital
2023
LWL-Universitätsklinikum Bochum
2013-2023
University Hospitals of the Ruhr-University of Bochum
2017-2023
Bielefeld University
2023
St. Josef-Hospital
2014-2021
University Hospital Leipzig
2000-2021
Deleted Institution
2021
CD4+CD25+ regulatory T cells can prevent and resolve intestinal inflammation in the murine cell transfer model of colitis. Using Foxp3 as a marker activity, we now provide comprehensive analysis vivo distribution Foxp3+CD4+CD25+ wild-type mice, during cure experimental In both cases, were found to accumulate colon secondary lymphoid organs. Importantly, Foxp3+ present at increased density samples from patients with ulcerative colitis or Crohn's disease, suggesting similarities behavior human...
Inhalt 1. Informationen zu dieser Leitlinie 462 1.1. Herausgeber 1.1.1. Federführende Fachgesellschaft 1.1.2. Kontakt 1.1.3. Verfügbare Dokumente zur 1.2. Besonderer Hinweis 1.3. Autoren 1.4. Ziele des Leitlinienprogramms Onkologie 2. Einführung 463 2.1. Geltungsbereich und Zweck 2.1.1. Zielsetzung Fragestellung 2.1.2. Adressaten 464 2.1.3. Verbreitung u. Implementierung d. Leitlinien 2.1.4. Finanzierung der Darlegung möglicher Interessenskonflikte 2.1.5. Gültigkeitsdauer...
To explore the impact of KRAS, NRAS and BRAF mutations as well KRAS mutation variants in patients with metastatic colorectal cancer (mCRC) receiving first-line therapy.A total 1239 from five randomized trials (FIRE-1, FIRE-3, AIOKRK0207, AIOKRK0604, RO91) were included into analysis. Outcome was evaluated by Kaplan-Meier method, log-rank tests Cox models.In 664 tumors, no detected, 462 tumors diagnosed KRAS-, 39 NRAS- 74 BRAF-mutation. Mutations associated inferior progression-free survival...
Bei diesem Dokument handelt es sich um die aktualisierte Fassung der 2006 erstmals erstellten S3-Leitlinie zum exokrinen Pankreaskarzinom.
Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established. To report the long-term results secondary end points prespecified in Randomized Phase 2 Trial Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Neoadjuvant Therapy (CAO/ARO/AIO-12 trial) Locally Advanced Rectal Cancer. This analysis a randomized clinical trial included 311 patients who were...
This trial investigated the addition of panitumumab to triplet chemotherapy with fluorouracil/folinic acid, oxaliplatin, and irinotecan (FOLFOXIRI) in a two-to-one randomized, controlled, open-label, phase II patients untreated RAS wild-type (WT) metastatic colorectal cancer.The primary end point was objective response rate (ORR) according RECIST (version 1.1). The experimental arm (modified FOLFOXIRI [mFOLFOXIRI] plus panitumumab) considered active if ORR ≥ 75%. compared an estimated 60%...
4008 Background: Chemotherapy (CT) is the standard of care in nonresectable locally advanced pancreatic cancer. The CONKO-007 trial studied role sequential CT and chemoradiotherapy (CRT). Methods: In this randomized multicenter phase III resectability was judged by an independent surgical board. Patients (pts) received induction chemotherapy (IC) for 3 months (3 cycles gemcitabine (Gem, 1000 mg/m² d1, 8, 15, q4w) or FOLFIRINOX (6 cycles, q2w)). After IC pts without progression were to either...
The Raf/MEK/ERK (mitogen activated protein kinase-MAPK) signal transduction cascade is an important mediator of a number cellular fates, including growth, proliferation, and survival. BRAF gene, one the human isoforms RAF, by oncogenic Ras, leading to cooperative effects in cells responding growth factor signals.The aim this study was elucidate possible function liver tumours.Mutations KRAS were evaluated 25 hepatocellular carcinomas (HCC) 69 cholangiocarcinomas (CC) direct DNA sequencing...
First, to analyze the strategy for 184 patients with hilar cholangiocarcinoma seen and treated at a single interdisciplinary hepatobiliary center during 10-year period. Second, compare long-term outcome in undergoing surgical or palliative treatment, third evaluate role of photodynamic therapy this concept.Tumor resection is attainable minority (<30%). When not possible, radiotherapy and/or chemotherapy have been found be an ineffective option. Recently, (PDT) has evaluated as neoadjuvant...
Abstract Phosphatase and tensin homologue deleted from chromosome 10 (PTEN) seems to be an important tumor suppressor gene in melanoma. Because the PTEN is only infrequently or mutated, because protein low absent a significant number of melanomas, we investigated alternative methods epigenetic silencing. We did quantitative positional methylation analysis (pyrosequencing) on 37 sera melanoma patients 21 pairs corresponding specimens addition Taqman reverse transcription-PCR. report promoter...
MicroRNAs (miRNAs) are RNA molecules that involved in the regulation of many cellular processes, including those related to human cancers. The aim this study was determine, as a proof principle, whether specific candidate miRNAs could be detected fine-needle aspirate (FNA) biopsies pancreatic ductal adenocarcinoma (PDAC) and accurately differentiate malignant from benign tissues.We used TaqMan(R) assays quantify miRNA levels FNA samples collected RNARetain (n = 16) compared results with...
Median survival time of nonresectable hilar bile duct cancer is only 4 to 6 months owing tumor spread in the biliary tree, refractory cholestasis, and sepsis or liver failure. We explored whether local photodynamic therapy could improve survival. A sample size 23 patients required detect an increase 6-month rate from less than 50% greater 70% a single-arm phase-II trial with statistical power 80% (Fleming’s single step procedure; α = 0.05). Twenty-three consecutive (8 women, 15 men; 67 ± 14...
Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and K-ras mutations are among most frequent genetic alterations in human malignancies.To investigate its possible association with intrahepatic cholangiocarcinomas liver.The status was evaluated 41 by methylation specific polymerase chain reaction, microsatellite analysis, DNA sequencing, immunohistochemical staining. were determined direct sequencing analyses after microdissection. The results obtained correlated...
Between 1972 and 1987, curative surgical resection (RO) was performed in 81 patients with ductal adenocarcinoma of the pancreas. In this study, slides from specimens were reviewed, histopathological features carcinomas retrospectively reevaluated. Tumor stage most important prognostic factor: UICC stages I, II, III, median survival times 13, 16, 8 mo, respectively. Lymph node involvement direct extension tumor into adjacent peripancreatic tissue, as well invasion organs found to...
Chemotherapy for advanced colorectal cancer leads to improved survival; however, predictors of response systemic treatment are not available. Genomic and epigenetic alterations the gene encoding transcription factor AP-2 epsilon (TFAP2E) common in human cancers. The dickkopf homolog 4 protein (DKK4) is a potential downstream target TFAP2E has been implicated chemotherapy resistance. We aimed further evaluate role DKK4 as chemotherapy.
Leitlinienprogramm Onkologie der AWMF, Deutschen Krebsgesellschaft e. V. und Krebshilfe
beta-Cell regeneration has been proposed as a possible treatment for diabetes, but the capacity new beta-cell formation in humans is yet unclear. In young rats, partial pancreatectomy prompts to restore mass. We addressed following questions: adult humans: 1) Does provoke and increased mass? 2) Is turnover after pancreatectomy?Protocol 1: human pancreatic tissue was collected from 13 patients who underwent two consecutive pancreas resections, markers of cell were determined both samples,...
The chemosensory capacity of the somatosensory system relies on appropriate expression chemoreceptors, which detect chemical stimuli and transduce sensory information into cellular signals. Knowledge complete repertoire chemoreceptors expressed in human ganglia is lacking. This study employed next-generation sequencing technique (RNA-Seq) to conduct first analysis trigeminal (TG) dorsal root (DRG). We analyzed data with a focus G-protein coupled receptors (GPCRs) ion channels, are...