A5013230086- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Facial Trauma and Fracture Management
- Head and Neck Surgical Oncology
- Intraocular Surgery and Lenses
- Neonatal Respiratory Health Research
- Dental Radiography and Imaging
- Corneal Surgery and Treatments
- Neurosurgical Procedures and Complications
- Traumatic Ocular and Foreign Body Injuries
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Ocular Disorders and Treatments
- Multiple Sclerosis Research Studies
- Neonatal Health and Biochemistry
- Peripheral Neuropathies and Disorders
- Orthodontics and Dentofacial Orthopedics
Medizinische Hochschule Hannover
2016-2025
Hochschule Hannover
2025
Ophthalmology Clinic
2021
Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg
2012-2020
University Hospital Regensburg
2011-2017
University of Regensburg
2004-2012
University Medical Center
2012
Lohmann (Germany)
2008
Technical University of Munich
2008
Universitäts-Augenklinik Bonn
2005
Purpose: Stargardt disease (STGD1) is an autosomal recessive retinopathy, caused by mutations in the retina-specific ATP-binding cassette transporter (ABCA4) gene. To establish mutational spectrum and to assess effects of selected deep intronic common genetic variants on disease, we performed a comprehensive sequence analysis large cohort German STGD1 patients. Methods: DNA samples 335 patients were analyzed for ABCA4 its 50 coding exons adjacent sequences resequencing array technology or...
Objective: We report the case of a young woman with postinfectious onset myasthenia gravis after COVID-19 mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department. Methods: Patient data were derived from medical records Hannover Medical School, Germany. Written informed consent was obtained patient. Results: The 21-year-old female patient presented subacute, vertically shifted double vision evoked by right sided partial oculomotor paresis ptosis....
Importance One of the biggest challenges when using anti–vascular endothelial growth factor (VEGF) agents to treat retinopathy prematurity (ROP) is need perform long-term follow-up examinations identify eyes at risk ROP reactivation requiring retreatment. Objective To evaluate whether an artificial intelligence (AI)–based vascular severity score (VSS) can be used analyze regression and after anti-VEGF treatment potentially Design, Setting, Participants This prognostic study was a secondary...
Leber congenital amaurosis caused by mutations in the RPE65 gene belongs to most severe early-onset hereditary childhood retinopathies naturally progressing legal blindness. The novel therapy voretigene neparvovec is first approved causative treatment option for this devastating eye disease and specifically designed treat RPE65-mediated retinal dystrophies. Herein, we present a follow-up of youngest treated patients Germany so far, including four pre-school children who received with at...
Patients with age-related macular degeneration (AMD) are reliant on their peripheral visual field. Oculomotor training can help them to find the best area intact retina and efficiently stabilize eccentric fixation. In this study, nine patients AMD were trained over a period of 6 months using oculomotor protocols improve fixation stability. They followed an additional months, where they completed auditory memory as sham training. cross-over design five started four Seven healthy age-matched...
Challenges in practice-oriented teaching at university clinics are increasing. A lack of resources contrasts a growing number students. Digital lectures, seminars, and blended-learning concepts enable resource-efficient effective ophthalmology. To implement evaluate digital concept combining bedside the Department Ophthalmology Hannover Medical School (MHH). Following National Competence-Based Learning Objectives Catalogue for Medicine (NKLM), theoretical units were combined with practical...
Abstract Inherited retinal dystrophies (IRDs) and inherited optic neuropathies (IONs) are characterized by distinct genetic causes molecular mechanisms that can lead to varying degrees of visual impairment. The discovery pathogenic variants in numerous genes associated with these conditions has deepened our understanding the pathways influence both vision disease manifestation may ultimately novel therapeutic approaches. Over past 18 years, DNA diagnostics unit been performing testing on...
Contemporary advances in technology have allowed the transfer of knowledge from industrial laser melting systems to surgery; such an approach could increase degree accuracy orbital restoration. The aim this study was examine selective melted PSIs (patient-specific implants) and navigation primary reconstruction. Ninety-six patients with fractures were included study. Planned vs. achieved volumes (a) angles (b) compared unaffected side (n = 96). analysis overlay post-treatment on planned...
Retinal microvasculature is known to be altered in patients with Fabry disease (FD). We aimed investigate the long-term changes macular and explore a reliable retinal biomarker for treatment monitoring FD. Prospective study of 26 eyes FD followed up 48 months (mean 24, range 8–48). OCT angiography (OCTA) images (2.9 × 2.9 mm) were obtained using Heidelberg Spectralis II at baseline follow-up. Macular vessel area density (VAD, %) was measured three layers: superficial vascular plexus (SVP),...
This study presents a case-control of 33 patients who underwent secondary orbital reconstruction, evaluating techniques and outcome.Adequate functional aesthetical appearance are main goals for reconstruction. Insufficient premorbid reconstruction can result in hypoglobus, enophthalmos, diplopia. Computer-assisted surgery the use patient-specific implants (PSIs) is widely described literature. The authors evaluate selective laser-melted PSIs hypothesize that an excellent option...
Inherited retinal diseases can result from various genetic defects and are one of the leading causes for blindness in working-age population. The present study aims to provide a comprehensive description changes structure associated with phenotypic disease entities underlying mutations. Full macular spectral domain optical coherence tomography scans were obtained manually segmented 16 patients retinitis pigmentosa, 7 cone−rod dystrophy, Stargardt disease, as well 23 age- sex-matched controls...
Abstract Purpose The German Retina.net ROP registry and its Europe‐wide successor, the EU‐ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure joint analyses different using exemplary datasets registries. Methods Exemplary databases over 1‐year period each (German Registry, 2011, 22 infants; 2021, 44 infants) were compared. documented in aligned analysed regarding demographic parameters, treatment...
Autosomal recessive bestrophinopathy (ARB) has been reported as clinically heterogeneous. Eighteen patients (mean age: 22.5 years; 15 unrelated families) underwent ophthalmological examination, fundus photography, autofluorescence, and optical coherence tomography (OCT). Molecular genetic testing of the BEST1 gene was conducted by chain-terminating dideoxynucleotide Sanger methodology. Onset symptoms (3 to 50 years age) best-corrected visual acuity (0.02–1.0) were highly variable....
Abstract A primary skeletal muscle cell culture, in which myoblasts derived from newborn rabbit hindlimb muscles grow on gelatin bead microcarriers suspension and differentiate into myotubes, has been established previously. In the course of differentiation beginning spontaneous contractions, these multinucleated myotubes do not detach their support. Here, we describe development with respect to ultrastructural differentiation. Scanning electron microscopy reveals that only around surface...
Proper treatment of the two-wall fractured orbit is still controversial. Specifically, there no consensus on issue necessity medial orbital wall repair. With anatomically critical structures at risk during surgical approach, surgeons' view repair often restricted and an aesthetically disturbing enophthalmos more likely to be accepted. Therefore, options range from leaving without reconstruction with autogenous tissue or alloplastic materials, which can lead moderate severe side effects....
The goal of this study was to evaluate macular microvascular changes in patients with Fabry disease (FD) using optical coherence tomography angiography (OCTA) and explore their correlation laboratory ocular findings.A total 76 eyes (38 patients) 48 24 healthy controls were enrolled prospective study. Vessel Area Density (VAD) Foveal Avascular Zone (FAZ) area calculated on 2.9 × mm OCTA images scanned the Heidelberg Spectralis II (Heidelberg, Germany). VAD measured three layers: Superficial...