A5015339066- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Optical Coherence Tomography Applications
- Ocular Diseases and Behçet’s Syndrome
- Acute Ischemic Stroke Management
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Cerebrovascular and Carotid Artery Diseases
- Blood properties and coagulation
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Antioxidant Activity and Oxidative Stress
- Homotopy and Cohomology in Algebraic Topology
- Systemic Lupus Erythematosus Research
- Algebraic structures and combinatorial models
- Drug-Induced Ocular Toxicity
- AI in cancer detection
- Digital Imaging for Blood Diseases
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinoids in leukemia and cellular processes
University Hospital of Bern
2016-2025
University of Bern
2016-2025
University of Regensburg
2023-2024
Otto-von-Guericke University Magdeburg
2022-2024
University of Tübingen
2006-2024
University of Geneva
2024
International Space Science Institute
2024
Heinrich Heine University Düsseldorf
2021-2023
Düsseldorf University Hospital
2023
Heidelberg University
2003-2023
The expression of vascular endothelial growth factor (VEGF) is elevated in diabetic macular edema (DME). Ranibizumab binds to and inhibits multiple VEGF variants. We investigated the safety efficacy ranibizumab DME involving foveal center.This was a 12-month, multicenter, sham-controlled, double-masked study with eyes (age>18 years, type 1 or 2 diabetes, central retinal thickness [CRT]≥300 μm, best corrected visual acuity [BCVA] 73-39 ETDRS letters [Early Treatment Diabetic Retinopathy...
To compare central retinal thickness (CRT) measurements in healthy eyes by different commercially available OCT instruments and to the intersession reproducibility of such measurements.Six (Stratus [Carl Zeiss Meditec, Inc. Dublin, CA], SOCT Copernicus [Reichert/Optopol Technology, Inc., Depew, NY], Spectral OCT/SLO [Opko/OTI, Miami, FL], RTVue-100 [Optovue Corp., Fremont, Spectralis HRA+OCT [Heidelberg Engineering, Heidelberg, Germany], Cirrus HD-OCT Inc.]) were used assess CRT both...
<h3>Background:</h3> Neovascular age-related macular degeneration (AMD) has a poor prognosis if left untreated, frequently resulting in legal blindness. Ranibizumab is approved for treating neovascular AMD. However, further guidance needed to assist ophthalmologists clinical practice optimise treatment outcomes. <h3>Methods:</h3> An international retina expert panel assessed evidence available from prospective, multicentre studies evaluating different ranibizumab schedules (ANCHOR, MARINA,...
Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use OCT MS research. Objective: An expert task force convened with aim provide guidance on validated quality control (QC) criteria for research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating an training set 50) was followed by...
The high prevalence of cardiovascular disease particularly in the elderly population is associated with retinal vascular disease. Retinal vein occlusions represent severe disturbances hypoxia-sensitive neurosensory retina. Acute and excessive leakage leads to diagnostic hallmarks hemorrhage edema substantial thickening. Advanced tools such as OCT angiography allow evaluate ischemia identify risk for late complications will soon reach clinical routine besides fluorescein angiography....
Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina nineteen healthy volunteers were scanned with OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). device-software generated en-face OCT-A images superficial (SCP) deep capillary plexuses (DCP) evaluated scored by 3 independent retinal imaging experts. SCP vessel density was assessed using...
Age-related macular degeneration (AMD) is the most frequent cause of blindness in elderly. There evidence that nutrition, inflammation and genetic risk factors play an important role development AMD. Recent studies suggest composition intestinal microbiome associated with metabolic diseases through modulation host metabolism. To investigate whether compositional functional alterations are AMD, we sequenced gut metagenomes patients AMD controls. The genera Anaerotruncus Oscillibacter as well...
To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising previously published Advised Protocol OCT Study Terminology and Elements (APOSTEL) recommendations.To identify studies we performed a PubMed search terms "quantitative" "optical tomography" from 2015 to 2017. Corresponding authors identified publications were invited provide feedback on initial APOSTEL via online surveys following principle modified Delphi...
PurposeTo compare the efficacy and safety of brolucizumab with aflibercept in patients diabetic macular edema (DME).DesignDouble-masked, 100-week, multicenter, active-controlled, randomized trials.MethodsSubjects were 1:1:1 to 3 mg/6 mg or 2 KESTREL (n = 566) 1:1 6 KITE 360). Brolucizumab groups received 5 loading doses every weeks (q6w) followed by 12-week (q12w) dosing, optional adjustment 8 (q8w) if disease activity was identified at predefined assessment visits; 4 (q4w) fixed q8w dosing....
The new scanning laser technique allows one to quantify the retinal microcirculation. A digital image analysing system was used study capillary blood flow velocities and morphological parameters of perifoveal intercapillary areas foveal avascular zones in normal diabetic subjects. Diabetic patients showed a significant reduction cell comparison with Perifoveal were significantly increased all stages retinopathy, both progressing retinopathy. Significant changes observed between subjects no
To describe and classify patterns of abnormal fundus autofluorescence (FAF) in eyes with early nonexudative age-related macular disease (AMD).FAF images were recorded AMD by confocal scanning laser ophthalmoscopy (cSLO) excitation at 488 nm (argon or OPSL laser) emission above 500 521 (barrier filter). A standardized protocol for image acquisition generation mean after automated alignment was applied, routine photographs obtained. FAF classified two independent observers. The kappa statistic...
purpose. To test the hypothesis that extension of areas with increased fundus autofluorescence (FAF) outside atrophic patches correlates rate spread geographic atrophy (GA) over time in eyes age-related macular degeneration (AMD). methods. The database multicenter longitudinal natural history Fundus Autofluorescence AMD (FAM) Study was reviewed for patients GA recruited through end August 2003, follow-up examinations within at least 1 year. Only sufficient image quality and diffuse patterns...
<h3>Objective:</h3> To compare cued recall measures with other memory and nonmemory tests regarding their association a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients mild cognitive impairment (MCI). <h3>Methods:</h3> Data were obtained by the German Dementia Competence Network. A total 185 clinic fulfilling broad criteria for MCI (1 SD deficit or tests) assessed an extended neuropsychological battery, which included Free Cued Selective Reminding Test (FCSRT),...
Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen wet age-related degeneration (AMD), although origin is still unknown; however, they reduced significantly during anti-VEGF (vascular endothelial growth factor) therapy, and their baseline amount seemed to correlate with treatment success. In this study behavior of was evaluated therapy for DME.Fifty-one...