A5030612595- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Coherence Tomography Applications
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Cytomegalovirus and herpesvirus research
- Cerebral Venous Sinus Thrombosis
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Neural Network Applications
- Systemic Lupus Erythematosus Research
- Ocular Oncology and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Domain Adaptation and Few-Shot Learning
- Ophthalmology and Eye Disorders
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Universitätsklinik für Augenheilkunde
2012-2023
Medical University of Vienna
2020
SIB Swiss Institute of Bioinformatics
2019
Xi'an Jiaotong University
2019
Creative Commons
2016
Oxford University Hospitals NHS Trust
2012-2013
The University of Western Australia
2009-2013
John Radcliffe Hospital
2012-2013
The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, and associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral axial joints, eyes, skin, ileum, colon. Genetic studies reveal common candidate genes for AS, PsA, Crohn's IL23R, IL12B, STAT3, CARD9, all which are interleukin-23 (IL-23) signaling downstream dectin 1 β-glucan receptor. In autoimmune-prone SKG mice mutated ZAP-70, attenuates T...
Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina nineteen healthy volunteers were scanned with OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). device-software generated en-face OCT-A images superficial (SCP) deep capillary plexuses (DCP) evaluated scored by 3 independent retinal imaging experts. SCP vessel density was assessed using...
Age-related macular degeneration (AMD) is the most frequent cause of blindness in elderly. There evidence that nutrition, inflammation and genetic risk factors play an important role development AMD. Recent studies suggest composition intestinal microbiome associated with metabolic diseases through modulation host metabolism. To investigate whether compositional functional alterations are AMD, we sequenced gut metagenomes patients AMD controls. The genera Anaerotruncus Oscillibacter as well...
Purpose.: Fundus autofluorescence (FAF) cannot only be characterized by the intensity or emission spectrum, but also its lifetime. As lifetime of a fluorescent molecule is sensitive to local microenvironment, this technique may provide more information than fundus imaging. We report here characteristics and repeatability FAF measurements human macula using new fluorescence imaging ophthalmoscope (FLIO). Methods.: A total 31 healthy phakic subjects were included in study with an age range...
Purpose: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) Early Treatment Diabetic Retinopathy Study severity grading. Methods: 3 mm × 12 scans were acquired cover 70° 80° of posterior pole a 100-kHz SS-OCTA instrument. Two masked graders assessed presence on level CFP. The grading results then compared. Results: A total 120 eyes (60...
To identify the prevalence and progression of macular atrophy (MA) in neovascular age-related degeneration (AMD) patients under long-term anti-vascular endothelial growth factor (VEGF) therapy to determine risk factors.This retrospective study included with AMD ≥30 anti-VEGF injections. Macular was measured using near infrared spectral-domain optical coherence tomography (SD-OCT). Yearly rate estimated square-root transformation adjust for baseline area allow linearization rate. Multiple...
Purpose: The purpose of this study was to describe autofluorescence lifetime characteristics in Stargardt disease (STGD) using fluorescence imaging ophthalmoscopy (FLIO) and investigate potential prognostic markers for activity progression. Methods: Fluorescence data 16 patients with STGD (mean age, 40 years; range, 22–56 years) 15 age-matched controls were acquired a ophthalmoscope based on Heidelberg Engineering Spectralis system. Autofluorescence excited 473-nm laser, decay times measured...
To assess the potential of machine learning to predict low and high treatment demand in real life patients with neovascular age-related macular degeneration (nAMD), retinal vein occlusion (RVO), diabetic edema (DME) treated according a treat-and-extend regimen (TER). Retrospective cohort study. Three hundred seventy-seven eyes (340 patients) nAMD 333 (285 RVO or DME anti–vascular endothelial growth factor agents (VEGF) predefined TER from 2014 through 2018. Eyes were grouped by disease into...
Abstract Background Dupilumab is used for the treatment of atopic dermatitis (AD). Approximately one third AD patients develop a dupilumab‐associated ocular surface disease (DAOSD), which pathomechanism poorly understood. This study aimed at investigating inflammatory markers in tear fluids on dupilumab therapy. Methods Tear were collected from with DAOSD (ADwDAOSD), without (ADw/oDAOSD), and non‐AD before during therapy, analyzed using specialized proteomic approach quantifying markers. The...
Androgenetic alopecia is characterized by a defined area of progressive nonscarring alopecia. The clinical and histological findings in 15 women 4 men with scarring pattern distribution were studied. results evaluated compared clinicopathologic entities that feature the central scalp area, specifically, lichen planopilaris, pseudopelade, follicular degeneration syndrome.Patients developed fibrosing scalp, without multifocal areas involvement typical planopilaris pseudopelade. Perifollicular...
Quantification of retinal layers using automated segmentation optical coherence tomography (OCT) images allows for longitudinal studies and neurological disorders in mice. The purpose this study was to compare the performance layer algorithms with data from manual mice Spectralis OCT.Spectral domain OCT 55 three different mouse strains were analyzed total. scans 22 C57Bl/6, BALBc, 11 C3A.Cg-Pde6b+Prph2Rd2 /J automatically segmented commercially available compared segmentation.Fully performed...
Purpose: To investigate fluorescence lifetime characteristics in patients with geographic atrophy (GA) eyes age-related macular degeneration and to correlate the measurements clinical data optical coherence tomography (OCT) findings. Methods: Patients GA were imaged a imaging ophthalmoscope. Retinal autofluorescence lifetimes measured short long spectral channel (498–560 nm 560–720 nm). Mean retinal analyzed within surrounding retina, correlated best corrected visual acuity OCT measurements....
Abstract Inherited monogenic diseases of the retina and vitreous affect approximately 1 in 2000 individuals. They are characterized by tremendous genetic heterogeneity clinical variability involving mutations 250 genes more than 20 different phenotypes. Clinical manifestations retinal dystrophies (RDs) range from mild dysfunctions to severe congenital forms blindness. A detailed diagnosis identification causative crucial for counseling affected patients their families, understanding...
To evaluate macular retinal ganglion cell thickness in patients with neovascular age-related degeneration (AMD) and intravitreal anti-vascular endothelial growth factor (VEGF) therapy.Retrospective case series fellow-eye comparison.Patients continuous unilateral anti-VEGF treatment for subfoveal juxtafoveal AMD a minimum follow-up of 24 months were included. The nerve fiber (RNFL) layer (RGCL) the macula segmented using an ETDRS grid. RNFL RGCL outer ring grid quantified at baseline after...
Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited scanned SS-OCTA surgery. Laser flare photometry performed post-surgery. Perfusion vessel density of superficial (SCP) deep capillary plexuses (DCP) the 3 × mm images as well foveal avascular zone (FAZ) measurements assessed. Vessel continuity, visibility presence artefacts...
Microglia-associated inflammation is closely related to the pathogenesis of various retinal diseases such as uveitis and diabetic retinopathy, which are associated with increased vascular permeability. In this study, we investigated effect systemic lipopolysaccharide (LPS) exposure activation proliferation microglia /macrophages. Balb/c Cx3cr1gfp/+ mice were challenged LPS (1 mg/kg) daily for four consecutive days. For depletion, treated colony-stimulating factor 1 receptor (CSF-1R)...
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the aged population. The etiology AMD multifactorial including nutritional factors, genetic variants mainly complement pathway, environmental risk factors and alterations intestinal microbiome. However, it remains unexplored whether there an interdependency these to development AMD. To investigate this issue, shotgun metagenomics analysis 57 neovascular 58 healthy controls as well 16 C3-deficient mice...
Age-related macular degeneration (AMD) affects millions of people globally, leading to a surge in online research putative diagnoses, causing potential misinformation and anxiety patients their parents. This study explores the efficacy artificial intelligence-derived large language models (LLMs) like addressing AMD patients' questions.ChatGPT 3.5 (2023), Bing AI Google Bard (2023) were adopted as LLMs. Patients' questions subdivided two question categories, (a) general medical advice (b)...