A5101877497- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Cerebral Venous Sinus Thrombosis
- Semiconductor Quantum Structures and Devices
- Photoreceptor and optogenetics research
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Advanced biosensing and bioanalysis techniques
- Optical Coherence Tomography Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Ophthalmology and Eye Disorders
- Ocular Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Connexins and lens biology
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
Nagasaki University
2020-2025
Hiroshima City Asa Citizens Hospital
2025
North Medical Center
2025
Citizens Specialty Hospitals
2025
Kyoto University
2015-2024
Santen (Japan)
2023
Bayer (Japan)
2023
Novartis (Japan)
2023
Japanese Red Cross Society, Japan
2022
University of Tokyo Hospital
2021
To investigate the relationship between subfoveal choroidal thickness, vascular hyperpermeability, and complement factor H (CFH) gene polymorphism in typical age-related macular degeneration (AMD) polypoidal vasculopathy (PCV).Fifty-eight patients with AMD 63 PCV underwent fluorescein angiography, indocyanine green angiography (IA), spectral-domain optical coherence tomography (OCT) using enhanced depth imaging (EDI). Subfoveal thickness was measured EDI-OCT images, hyperpermeability...
Abstract Pachychoroid neovasculopathy is a recently proposed clinical entity of choroidal neovascularization (CNV). As it often masquerades as neovascular age-related macular degeneration (AMD), currently controversial whether pachychoroid should be distinguished from AMD. This because its characteristics have yet to well described. To estimate the relative prevalence in comparison with AMD and investigate phenotypic/genetic differences two diseases, we evaluated 200 consecutive Japanese...
Purpose.: Retinitis pigmentosa (RP), a major cause of blindness in developed countries, has multiple causative genes; its prevalence differs by ethnicity. Usher syndrome is the most common form syndromic RP and accompanied hearing impairment. Although molecular diagnosis challenging, recent technological advances such as targeted high-throughput resequencing are efficient screening tools. Methods.: We performed comprehensive testing 329 Japanese patients using custom capture panel that...
To identify reticular pseudodrusen (RPD) in age-related macular degeneration using multiple imaging modalities, including the blue channel image of fundus photography, infrared reflectance (IR), autofluorescence, near-infrared confocal reflectance, indocyanine green angiography, and spectral-domain optical coherence tomography (SD-OCT), to compare sensitivities specificities these modalities for detecting RPD.This study included 220 eyes from 114 patients with newly diagnosed degeneration....
Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed characteristic increase of choroidal thickness in CSC, we conducted genome-wide association study on 3,418 individuals followed by TaqMan assays 2,692 subjects, identified two susceptibility loci: CFH rs800292, an established AMD polymorphism, VIPR2 rs3793217 (P = 2.05 ×...
To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) its associations with responses to three monthly anti-VEGF injections as an initial treatment for two conditions.This study included nine eyes treatment-naïve 21 nAMD. Before intravitreal injection, aqueous humor samples were collected of VEGF was measured using enzyme-linked immunosorbent assay. The...
Inherited retinal dystrophies (IRDs) are progressive diseases leading to vision loss. Mutation in the eyes shut homolog (EYS) gene is one of most frequent causes IRD. However, mechanism photoreceptor cell degeneration by mutant EYS has not been fully elucidated. Here, we generated organoids from induced pluripotent stem cells (iPSCs) derived patients with EYS-associated dystrophy (EYS-RD). In RD organoids, both and G protein–coupled receptor kinase 7 (GRK7), proteins handling phototoxicity,...
Purpose.: To quantify the angle of view, magnification, and quality images acquired with an Optos 200Tx. Methods.: We obtained fundus a model eye 200Tx recorded maximal scale imaged in each direction. measured length bar interval bars at calculated magnification. also contrast between intervals bars. Results.: The image covered 96, 101, 76, 102° up, right, down, left directions, respectively. Quantitative measurement showed that overall is stretched 1.12-fold horizontal direction respect to...
Background: Retinal and optic disc perfusion in nonarteritic anterior ischemic neuropathy (NAION) is incompletely understood. Our aim was to investigate the characteristics of microvascular structures at peripapillary area disc, their associations with retinal structure function patients NAION. Methods: We conducted a prospective, observational case series study. Thirty-four eyes, consisting 15 NAION eyes 19 normal were included. Optical coherence tomography (OCT) angiography used measure...