Yasuharu Tabara
A5013879304- Cardiovascular Health and Disease Prevention
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Nutritional Studies and Diet
- Obstructive Sleep Apnea Research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Sleep and related disorders
- Regulation of Appetite and Obesity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Body Composition Measurement Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Disease and Adiposity
- Frailty in Older Adults
- Glaucoma and retinal disorders
- Cerebrovascular and Carotid Artery Diseases
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Retinal Imaging and Analysis
Kyoto University
2016-2025
University of Shizuoka
2021-2025
GTx (United States)
2008-2025
Center for Genomic Science
2017-2025
Shiga University of Medical Science
2010-2023
Center for Rheumatology
2021
Tokushima University
2021
Teikyo University
2021
Shizuoka General Hospital
2020-2021
Taipei Veterans General Hospital
2021
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients primary aldosteronism (PA); however, their results left it unclear whether CVD is affected by plasma aldosterone concentration or hypokalemia. We assessed PA database established multicenter JPAS (Japan Primary Aldosteronism Study) and compared prevalence of among that age-, sex-, blood pressure-matched essential hypertension participants a general population cohort. also...
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese patients and 375 population-based controls, because trisomy is known be associated early deposition of beta-amyloid (Abeta) in the brain. Among 417 markers spanning 33 Mb, 22 showed either allele or genotype frequency (P < 0.05). Logistic regression analysis age, sex apolipoprotein E (APOE)-epsilon4 dose supported risk 17 markers, which eight were linked SAMSN1, PRSS7,...
OBJECTIVE—Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes susceptibility by enhancing activity. report here on relation between plasma and either SNP or factors related to resistance. RESEARCH DESIGN AND METHODS—We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending yearly medical checkup. The was...
The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, KCNJ11 were analyzed.Candidate SNPs genotyped 506 402 control subjects meta-analyzed with six previous patients. Associations fasting plasma insulin levels...
Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and branches of the aorta. Ulcerative colitis (UC) prevalent autoimmune colitis. Since TAK UC share HLA–B*52:01 IL12B as genetic determinants, since there are case reports co‐occurrence these diseases, we hypothesized that common complication TAK. We undertook this study to perform large‐scale analysis TAK, both evaluate prevalence concurrent cases identify estimate susceptibility genes shared between 2...
Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients diabetes relatively higher glycemic levels. Here, we aimed clarify control was associated in type 2 diabetes.Study participants consisted of (n = 746, average age 69.9 years) an older general population 2,067, 68.2 years). Sarcopenia defined as weak grip strength or slow usual gait speed low skeletal...
Profiles of sequence variants that influence gene transcription are very important for understanding mechanisms affect phenotypic variation and disease susceptibility. Using genotypes at 1.4 million SNPs a comprehensive transcriptional profile 15,454 coding genes 6,113 lincRNA obtained from peripheral blood cells 298 Japanese individuals, we mapped expression quantitative trait loci (eQTLs). We identified 3,804 cis-eQTLs (within 500 kb target genes) 165 trans-eQTLs (>500 away or on different...
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed characteristic increase of choroidal thickness in CSC, we conducted genome-wide association study on 3,418 individuals followed by TaqMan assays 2,692 subjects, identified two susceptibility loci: CFH rs800292, an established AMD polymorphism, VIPR2 rs3793217 (P = 2.05 ×...
ObjectivesType 2 diabetes is a risk factor for sarcopenia. Evidence on the prevention of sarcopenia using blood glucose–lowering therapy limited. We aimed to examine relationship between changes in glycemic control and effect antidiabetic agents against patients with type diabetes.DesignWe conducted an observational longitudinal study.Setting ParticipantsIn total, 588 Japanese ongoing multicenter study completed 1-year follow-up measurements clinical data.MethodsThe data set Multicenter...