Constance Bordes
A5053720933- Genetic Associations and Epidemiology
- Fetal and Pediatric Neurological Disorders
- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
- Bioinformatics and Genomic Networks
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Lipoproteins and Cardiovascular Health
- Genetic and Kidney Cyst Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
- Genomics and Rare Diseases
Bordeaux Population Health
2020-2023
Inserm
2020-2023
Université de Bordeaux
2019-2023
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
Abstract Previous genome-wide association studies (GWAS) of stroke, the second leading cause death, have been conducted in populations predominantly European ancestry.1,2 We undertook cross-ancestry GWAS meta-analyses stroke and its subtypes 110,182 patients (33% non-European) 1,503,898 control individuals five ancestries from population- clinic-based studies, nearly doubling number cases previous GWAS. identified signals at 89 independent loci, which 61 were novel. Effect sizes overall...
Background and Objectives: Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions incidental findings (IFs) this age group are scarce. We aimed to assess the prevalence severity IFs on MRIs young research participants aged 18–35 years, describe protocol implemented handle them. Methods: The study population comprised 1,867 22.1 ± 2.3 years (72% women) from MRi-Share, cross-sectional MRI substudy i-Share student cohort. were...
Abstract Perivascular space burden (PVS) is an emerging and possibly the earliest magnetic resonance imaging (MRI)-marker of cerebral small vessel disease (cSVD), a leading cause stroke dementia. Its molecular underpinnings are unknown. Genome-wide whole-exome association studies in 40,095 participants (21 population-based cohorts, 66.3±8.6 years) revealed 24 genome-wide significant PVS risk loci. These showed with white matter already at age 20, suggesting important role early-life factors....