A5030655846- Acute Ischemic Stroke Management
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Antibiotic Resistance in Bacteria
- Antiplatelet Therapy and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Synthesis of β-Lactam Compounds
- Blood groups and transfusion
- Vibrio bacteria research studies
- Neurological and metabolic disorders
- Photodynamic Therapy Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Childhood Cancer Survivors' Quality of Life
- Synthesis and Catalytic Reactions
- Bacterial Identification and Susceptibility Testing
- Voice and Speech Disorders
- Intracranial Aneurysms: Treatment and Complications
- Endodontics and Root Canal Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Issues in Pregnancy
- Antifungal resistance and susceptibility
- Blood Coagulation and Thrombosis Mechanisms
- Infections and bacterial resistance
- Stroke Rehabilitation and Recovery
Universidade da Região de Joinville
2011-2023
Pontifícia Universidade Católica do Paraná
2015
Pontifícia Universidade Católica de São Paulo
2014
Universidade do Vale do Paraíba
2003
ABSTRACT Paracoccidioides brasiliensis , a thermodimorphic fungus, is the causative agent of prevalent systemic mycosis in Latin America, paracoccidioidomycosis. We present here survey expressed genes yeast pathogenic phase P. . obtained 13,490 sequence tags from both 5′ and 3′ ends. Clustering analysis yielded partial sequences 4,692 that were functionally classified by similarity to known genes. have identified several Candida albicans virulence pathogenicity homologues Furthermore, we...
Objective and background: The aim of this in vitro study was to compare the efficiency a photodynamic therapy (PDT) technique employing rose bengal (RB) methylene blue (MB) as photosensitizers (PSs) reduce viability Enterococcus faecalis, well-known pathogen found root canal systems. Currently, several clinical applications, including field endodontics, MB is employed association with red laser source for photoinactivation pathogenic bacteria. Methods: In study, used at 0.01% (31.2 mol/L)...
Background Stroke is the second leading cause of death in Brazil. The social and financial burden stroke remarkable; however, epidemiological profile remains poorly understood. Objective aim this study was to report incidence, lethality, functional status at 30 90 days post-stroke cities different Brazilian macro-regions. Methods This an observational, prospective, population-based study, led Canoas (South), Joinville (South, reference center), Sertãozinho (Southeast), Sobral (Northeast) It...
Members of the Acinetobacter genus are key pathogens that cause healthcare-associated infections, and they tend to spread develop new antibiotic resistance mechanisms. Oxacillinases primarily responsible for carbapenem antibiotics. Higher rates hydrolysis might be ascribed insertion sequences, such as ISAba1 sequence, near bla OXA genes. The present study examined occurrence genetic elements their relationship with susceptibility carbapenems in clinical isolates calcoaceticus-Acinetobacter...
INTRODUCTION: Carbapenems are the therapy of choice for treating severe infections caused by Acinetobacter calcoaceticus-Acinetobacter baumannii complex. We aimed to assess prevalence and antimicrobial susceptibility profiles producers distinct oxacillinases among nosocomial isolates A. calcoaceticus-A. complex in a 249-bed general hospital located Joinville, Southern Brazil. METHODS: Of 139 clinical with reduced carbapenems between 2010 2013, 118 from varying anatomical sites sectors were...
Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved there link between the ABO blood group system and occurrence thrombotic events. Nonetheless, its association with IS not well established.For reason, purpose hereof was to investigate relation groups Brazilian cohort cerebrovascular diseases.Five hundred twenty-nine subjects were included over 12 months, from which 275 presented an episode 254 composed control group....
The incidence of bacterbilia in cholelithiasis remains controversial. positivity cultures ranges from 0 to 73 per cent. aim this study was employ the polymerase chain reaction (PCR) detect bacterial DNA gallbladder bile extracted during elective laparoscopic cholecystectomy, and compare PCR findings with those culture.Bile samples 84 cholecystectomies were collected for culture analysis.Positive results found 42 (50 cent) patients by but only 16 (19 (P < 0.001). Agreement between two methods...
Sepsis is a systemic inflammatory response related to high mortality rates in the hospital environment. Delayed etiological diagnosis and inadequate antimicrobial therapy are associated with treatment failures. Molecular tests based on polymerase chain reaction regarded as faster more accurate procedures than culture techniques for microbial identification, providing higher rate of therapeutic success.To develop panel primers DNA fragments sepsis-related microorganisms.Primers amplification...
CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment inflammatory bowel disease, transplantation acute leukemias. Despite their effectiveness, these are capable causing drug-induced toxicity with risk death by myelosuppression. It is now known that complications occur because genetic polymorphisms thiopurinemethyltransferase (TPMT) enzyme, responsible for its metabolism. OBJECTIVE: To assess prevalence methyltransferase...
Abstract Previous genome-wide association studies (GWAS) of stroke, the second leading cause death, have been conducted in populations predominantly European ancestry.1,2 We undertook cross-ancestry GWAS meta-analyses stroke and its subtypes 110,182 patients (33% non-European) 1,503,898 control individuals five ancestries from population- clinic-based studies, nearly doubling number cases previous GWAS. identified signals at 89 independent loci, which 61 were novel. Effect sizes overall...
ContextCrohn’s disease is characterized by a chronic and debilitating inflammatory disorder of the gastrointestinal tract. Several factors may contribute to its development. From extensive studies human genome, polymorphism T300A gene ATG16L1 (autophagy-related 16-like 1) has been related increased risk developing this disease.ObjectivesAnalyze role (rs2241880) in patients with Crohn’s disease.Methods238 samples from (control group) 106 recruited at five Southern Brazilian reference centers...
Introduction: Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by human immunodeficiency (HIV) influences course of HCV contributing to liver damage. Nevertheless, little is known about relationship between these SNPs and HCV/HIV coinfection. Our aim was estimate relevance allelic genotypic variants rs12979860 (C/T) rs8099917 (T/G) on establishment infection in mono-infected coinfected patients....
Aiming to contribute studies that use detailed clinical and genomic information of biobanks, we present the initial results first Latin American Stroke Biobank.Blood samples were collected from patients included in Joinville Registry four Brazilian cities. Demographic socio-economic data, cardiovascular risk factors, Causative Classification System for Ischemic Stroke, Trial Org 10172 Acute Treatment National Institutes Health scores, functional stroke status (modified Rankin) brain images...
Os estudos em biologia molecular desenvolvidos nas últimas décadas, possibilitaram grandes avanços para uma maior compreensão da carcinogênese colorretal. Na década de 80 pesquisadores descobriram proteína com a capacidade aumentar permeabilidade dos vasos sangüíneos. Inicialmente esta foi denominada como fator vascular. Estudos posteriores correlacionaram o crescimento novos sangüíneos (angiogênese), quando passou ser chamada endotelial vascular (VEGF). A VEGF tem sido apontada principal...
Introduction: Following an overview of anatomic and physiologic changes found in studies normal aging phonation, this study examines findings on respiratory parameters a group elderly subjects.