Tavia E. Evans
A5077822802- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Nuclear Receptors and Signaling
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
- Craniofacial Disorders and Treatments
- Bioinformatics and Genomic Networks
- Cancer-related Molecular Pathways
- Ethics in Clinical Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholinesterase and Neurodegenerative Diseases
- Biomedical and Engineering Education
- Memory and Neural Mechanisms
- Genomic variations and chromosomal abnormalities
- Mitochondrial Function and Pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Telomeres, Telomerase, and Senescence
- Pregnancy and preeclampsia studies
- Genetic and Kidney Cyst Diseases
Erasmus MC
2016-2024
Erasmus University Rotterdam
2016-2024
Radboud University Medical Center
2024
Radboud University Nijmegen
2024
Trinity College Dublin
2024
Medical University of Graz
2022
National University of Singapore
2022
Stanford University
2022
The University of Texas Health Science Center at San Antonio
2022
German Center for Neurodegenerative Diseases
2022
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex parcellated internal structure, the role of subregions hippocampus in cognition risk dementia remains relatively underexplored. We studied a large population-based cohort further understand their impairment risk.We 5035 dementia- stroke-free persons from Rotterdam Study, aged over 45 years. All participants underwent magnetic resonance imaging (1.5 T) between 2005 2015. Automatic...
Perivascular spaces (PVS) are emerging markers of cerebral small vessel disease (CSVD), but research on their determinants has been hampered by conflicting results from single studies using heterogeneous rating methods. In this study, we therefore aimed to identify PVS burden in a pooled analysis multiple cohort 1 harmonized method.Individuals 10 population-based with adult participants the Uniform Neuro-Imaging Virchow-Robin Spaces Enlargement consortium and UK Biobank were included. On MRI...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- interrater variability. Automated rating may benefit biomedical research, as well clinical assessment, diagnostic reliability existing algorithms unknown. Here, we present the results VAscular Lesions DetectiOn Segmentation (Where VALDO?) challenge that was run a satellite event at international conference Medical...
Abstract Introduction Volumetric and morphological changes in subcortical brain structures are present persons with dementia, but it is unknown if these occur prior to diagnosis. Methods Between 2005 2016, 5522 Rotterdam Study participants (mean age: 64.4) underwent cerebral magnetic resonance imaging (MRI) were followed for development of dementia until 2018. Volume shape measures obtained seven structures. Results During 12 years follow‐up, 272 cases occurred. Mean volumes thalamus (hazard...
The presence of subclinical vascular brain disease, including white matter lesions and lacunar infarcts, substantially increases the risk clinical stroke. White microstructural integrity is considered an earlier, potentially better, marker total burden disease. Its association with stroke, a focal event, remains unknown.From population-based Rotterdam Study, 4259 stroke-free participants (mean age: 63.6 years, 55.6% women) underwent magnetic resonance imaging, diffusion between 2006 2011....
Individual differences in memory during ageing are associated with the microstructure of fornix, a bidirectional tract connecting hippocampus diencephalon, basal forebrain and cortex. To investigate origin alterations fornix microstructure, measurement hippocampal subfield volumes was combined diffusion MRI cognitive evaluation new sample 31 healthy human participants aged 50-89 years. The uncinate parahippocampal cingulum were reconstructed using tractography. Episodic assessed free cued...
The hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during progression. This study investigates 5-year trajectories of hippocampal volumes across AD stages, focusing on genetic predisposition to their impact atrophy. Analyzing data from 1,051 participants the ADNI, we found that higher accelerates atrophy, particularly individuals with mild impairment (MCI). Effects were primarily driven by cerebrospinal fluid protein quantitative trait loci APOE....
The peripartum period is the highest risk interval for onset or exacerbation of psychiatric illness in women's lives. Notably, pregnancy and childbirth have been associated with short-term structural functional changes maternal human brain. Yet long-term effects on brain structure remain unknown. We investigated a large population-based cohort to examine association between parity structure. In total, 2,835 women (mean age 65.2 years; all free from dementia, stroke, cortical infarcts)...
Abstract The size of the human head is determined by growth in first years life, while rest body typically grows until early adulthood 1 . Such complex developmental processes are regulated various genes and pathways 2 Rare genetic syndromes have revealed that affect 3 , but drivers variation within general population remain largely unknown. To elucidate biological underlying head, we performed largest genome-wide association study on to date (N = 79,107). We identified 67 loci, 50 which...
Abstract Background Current evidence supports the involvement of brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism, and ε4 allele APOE gene in hippocampal-dependent functions. Previous studies on association with whole hippocampal volume included patients a variety disorders. However, it remains to be elucidated whether there is an impact polymorphism volumes subfield (HSv) cognitively unimpaired (CU) individuals, interactive effect -ε4 status. Methods genotypes were...
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of genes important to biology in general, and particularly identifying components unique intramembranous ossification, which cannot be captured at other skeletal sites. We assessed genetic determinants SK-BMD 43,800 individuals, 59 genome-wide significant loci (4 novel), explaining 12.5% its variance. Pathway enrichment analyses association signals resulted clustering within gene-sets involved regulating...
The interocular distance, or orbital telorism, is a distinctive craniofacial trait that also serves as clinically informative measure. While its extremes, hypo- and hypertelorism, have been linked to monogenic disorders are often syndromic, little known about the genetic determinants of distance within general population. We derived telorism measures from cranial magnetic resonance imaging by calculating between eyeballs' centre gravity, which showed good reproducibility with an intraclass...
Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- interrater variability. Automated rating may benefit biomedical research, as well clinical assessment, diagnostic reliability existing algorithms unknown. Here, we present the results \textit{VAscular Lesions DetectiOn Segmentation} (\textit{Where VALDO?}) challenge that was run a satellite event at international...
Abstract Background Perivascular space (PVS) burden is an emerging MRI‐marker of cerebral small vessel disease (cSVD), a leading cause stroke and dementia. Underlying mechanisms PVS are unknown. thought to be related the glymphatic system, involved in brain clearance molecules such as amyloid beta. We aimed decipher genetic underpinnings burden. Method conducted genome‐wide whole‐exome association studies N = 39,823 participants for white matter (WM) PVS, 40,000 basal ganglia (BG) 40,095...
Abstract The radial unit hypothesis provides a framework for global (proliferation) and regional (distribution) expansion of the primate cerebral cortex. Using principal component analysis (PCA), we have identified cortical regions with shared variance in their surface area thickness, respectively, segmented from magnetic resonance images obtained 23,800 participants. We then carried out meta-analyses genome-wide association studies first two components each phenotype. For (but not...
Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) how relationships vary sources