A5061008483- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Nutritional Studies and Diet
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Cancer-related Molecular Pathways
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Cognitive Abilities and Testing
- Acute Ischemic Stroke Management
- Early Childhood Education and Development
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Blood Pressure and Hypertension Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Genomic variations and chromosomal abnormalities
- Birth, Development, and Health
- Genetic Mapping and Diversity in Plants and Animals
- Language Development and Disorders
- Molecular Communication and Nanonetworks
- Neural dynamics and brain function
Erasmus MC
2014-2024
Erasmus University Rotterdam
2013-2022
Harvard University
2020
Background: Over the past few decades, bullying has been recognized as a considerable public health concern. Involvement in is associated with poor long-term social and psychiatric outcomes for both perpetrators targets of bullying. Despite this concerning prognosis, studies have investigated possible neurobiological correlates involvement that may explain impact Cortical thickness ideally suited examining deviations typical brain development, it shown to detect subtle differences children...
Gyrification of the cerebral cortex changes with aging and relates to development cognitive function during early life midlife. Little is known about how gyrification age later in life. We investigated this 4397 individuals (mean age: 63.5 years, range: 45.7 97.9) from Rotterdam Study, a population-based cohort. Global local were assessed T1-weighted images. A measure for global cognition, g-factor, was calculated five tests. Older associated lower difference per year = −0.0021; 95%...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Background: We aimed to explore whether adhering a more plant-based diet, beyond strict vegan or vegetarian diets, may help prevent adiposity in middle-aged and elderly population. Methods: included 9,633 participants from the Rotterdam Study, prospective cohort Netherlands. Dietary data were collected using food-frequency questionnaires at baseline of three subcohorts Study (1989–1993, 2000–2001, 2006–2008). created diet index by giving foods positive scores animal-based reverse scores. A...
Understanding the development of white matter microstructure in general population is an imperative precursor to identifying its involvement psychopathology. Previous studies have reported changes associated with age and different developmental patterns between boys girls. Handedness has also been related adults. Motor performance, tightly dependent on overall neuronal myelination, corpus callosum. However, association motor performance global not literature. In general, these age, sex,...
A higher cognitive reserve and brain could decrease mortality risk, but the interaction of these factors with general age-related loss physical fitness (eg, frailty) remains unclear regards to mortality. We investigated associations frailty within associations.Within observational population-based cohort Rotterdam Study, we included participants who visited research centre for a assessment between March 2, 2009, 1, 2012. Participants an incomplete cognition, no data on education attainment,...
Abstract Background The American Heart Association recently released an updated algorithm for evaluating cardiovascular health—Life’s Essential 8 (LE8). However, the associations between changes in LE8 score over time and risk of disease (CVD) remain unclear. Methods We investigated 6-year (2006–12) subsequent CVD events (2012–20) among 53 363 Chinese men women from Kailuan Study, who were free 2012. was calculated based on eight components: diet quality, physical activity, smoking status,...
Brain morphology is altered in both anorexia nervosa and obesity. However, it yet unclear if the relationship between Body Mass Index-Standard Deviation Score (BMI-SDS) brain exists across BMI-SDS spectrum, or present only extremes. The study involved 3160 9-to-11 year-old children (50.3% female) who participate Generation R, a population-based study. Structural MRI scans were obtained from all FreeSurfer was used to quantify global surface-based measures of gyrification cortical thickness....
ABSTRACT Objective Monogenic disorders (MDs), often associated with developmental delay, intellectual disability, hypotonia, or dysmorphic facial features, typically go undetected during pregnancy. These are frequently caused by de novo single nucleotide variants (SNVs), which not currently covered routine non‐invasive prenatal testing (NIPT). This screening gap limits informed decision‐making in pregnancy and can lead to the unexpected birth of neonates severe conditions. The aim this study...
Background: Individual differences in the risk to develop dementia remain poorly understood. These may partly be explained through reserve, which is ability buffer cognitive decline due neuropathology and age. Objective: To determine how much early late–life reserve (CR) brain (BR) contribute of dementia. Methods: 4,112 dementia-free participants (mean age = 66.3 years) from Rotterdam Study were followed up for on average 6.0 years. Early-life CR BR defined as attained education intracranial...
Abstract A combination of genetic and environmental factors contributes to the origins autism spectrum disorder (ASD). While a number studies have described specific associating with emerging ASD, that compare contrast multiple in same study are lacking. Thus, goal this was perform prospective, data‐driven environmental‐wide association pre‐ perinatal associated later development autistic symptoms childhood. The participants included 3891 6‐year‐old children from birth cohort data. Autistic...
The cerebral cortex is fundamental to the functioning of mind and body. In vivo cortical morphology can be studied through magnetic resonance imaging in several ways, including reconstructing surface-based models cortex. However, existing software for statistical analyses cannot accommodate "big data" or commonly used methods such as imputation missing data, extensive bias correction, non-linear modeling. To address these shortcomings, we developed QDECR package, a flexible extensible R...
Background High blood pressure levels and higher arterial stiffness have been shown to be associated with lower cognition during adulthood, possibly by accumulative changes over time. However, vascular factors may already affect the brain early life. Methods Results We examined relation between within 5853 children from Generation R Study (mean age 6.2 years) 5187 adults Rotterdam 61.8 years). Diastolic systolic were assessed, latter measuring pulse‐wave velocity pulse pressure. For...
Cognitive reserve aims to explain individual differences in the susceptibility functional impact of dementia presence equal amount neuropathological damage. It is thought be shaped by a combination innate and lifetime exposures. Which determinants are associated with cognitive remains unknown.The objective this study was investigate associations sociodemographic, lifestyle, physical, psychosocial reserve, potential sex differences.This cross-sectional included 4,309 participants from...
Stuttering is a complex speech fluency disorder occurring in childhood. In young children, stuttering has been associated with speech-related auditory and motor areas of the brain. During transition into adolescence, majority children who stutter (75–80%) will experience remission their symptoms. The current study evaluated brain (micro-)structural differences between pre-adolescents persisted stuttering, those recovered, fluently speaking controls. This was embedded Generation R Study,...
Background: Genetics play a significant role in the etiology of late-life neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Part individual differences risk for these can be traced back decades before onset symptoms. Previous studies have shown evidence plausible links APOE, most important genetic marker with early-life cognition neuroimaging markers. We aimed to assess whether genome-wide burden aforementioned plays processes. Methods:...
Associations between attention-deficit/hyperactivity disorder (ADHD) and brain morphology have been reported, although with several inconsistencies. These may partly stem from confounding bias, which could distort associations limit generalizability. We examined how ADHD symptoms change adjustments for potential confounders typically overlooked in the literature (aim 1), intelligence quotient (IQ) head motion, are generally corrected but play ambiguous roles 2). Participants were 10-year-old...
Abstract Individual differences in subcortical brain volumes are highly heritable. Previous studies have identified genetic variants that underlie variation adults. We tested whether those previously also affect regions during infancy and early childhood. The study was performed within the Generation R study, a prospective birth cohort. calculated polygenic scores based on reported GWAS for of accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen, thalamus. Participants...