A5046177284- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Pregnancy and preeclampsia studies
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Per- and polyfluoroalkyl substances research
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Preterm Birth and Chorioamnionitis
- Fatty Acid Research and Health
- Carcinogens and Genotoxicity Assessment
- Climate Change and Health Impacts
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Risks and Factors
- Pregnancy-related medical research
- Pesticide Exposure and Toxicity
- Advanced Causal Inference Techniques
- Thyroid Disorders and Treatments
- Trace Elements in Health
- Statistical Methods and Bayesian Inference
- Chemical Analysis and Environmental Impact
- Statistical Methods and Inference
- Anesthesia and Neurotoxicity Research
National Institute of Environmental Health Sciences
2016-2025
Triangle
2016-2025
National Institutes of Health
2017-2024
Ohio University
2009-2024
Harvard University
1992-2023
University of North Carolina at Chapel Hill
2019-2023
Centers for Disease Control and Prevention
2023
Scientific Systems (United States)
2023
Social and Scientific Systems (United States)
2023
Milken Institute
2023
Background: Exposure mixtures frequently occur in data across many domains, particularly the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect mixture components. Objectives: We demonstrate new approach estimating effects mixture: g-computation. This combines inferential simplicity WQS with flexibility g-computation,...
Puerto Rico has higher rates of a range endocrine-related diseases and disorders compared to the United States. However, little is known date about human exposures or potential endocrine disrupting chemicals (EDCs) in Rico. We recruited 105 pregnant women Northern who provided urine samples questionnaire data at three times (18 ± 2, 22 26 2 weeks) during gestation. measured urinary concentrations five phenols parabens: 2,4-dichlorophenol (24-DCP), 2,5-dichlorophenol (25-DCP), benzophenone-3...
<h3>Importance</h3> Preterm birth is a leading cause of neonatal mortality, with variety contributing causes and risk factors. Environmental exposures represent group understudied, but potentially important, Phthalate diesters are used extensively in consumer products worldwide. Consequently, exposure pregnant women highly prevalent. <h3>Objective</h3> To assess the relationship between phthalate during pregnancy preterm birth. <h3>Design, Setting, Participants</h3> This nested case-control...
Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling.
Phthalate exposure occurs readily in the environment and has been associated with an array of health end points, including adverse birth outcomes. Some these may be mediated by oxidative stress, a proposed mechanism for phthalate action.In present study, we explored associations between metabolites biomarkers stress measured urine samples from multiple time points during pregnancy.Women were participants nested case-control study preterm (n = 130 cases, n 352 controls). Each was recruited...
There is evidence of declining trends in T levels among men recent decades, as well related conditions at multiple life stages and both sexes. also animal limited human that exposure to phthalates, chemicals found plastics personal care products, associated with reduced androgen disorders. To explore relationships between urinary concentrations 13 phthalate metabolites serum total men, women, children when adjusting for important confounders stratifying by sex age (6–12, 12–20, 20–40, 40–60,...
Phthalate exposure during pregnancy has been linked to adverse birth outcomes such as preterm birth, and inflammation oxidative stress may mediate these relationships. In a prospective cohort study of pregnant women recruited early in gestation Northern Puerto Rico, we investigated the associations between urinary phthalate metabolites biomarkers inflammation, including C-reactive protein, IL-1β, IL-6, IL-10, TNF-α, stress, 8-hydroxydeoxyguanosine (OHdG) 8-isoprostane. Inflammation were...
Problem Previous studies have investigated the utility of inflammation markers as predictors preterm birth, but none compared trends in levels between uncomplicated and pregnancy. Method study We explored longitudinal changes plasma cytokines, including IL ‐1β, ‐6, ‐10, TNF ‐α, well C‐reactive protein pregnant women from a nested case–control study. Results ‐6 was associated with increased odds spontaneous defined by presentation labor and/or premature rupture membranes. Associations were...
Increasing scientific evidence suggests that exposure to phthalates during pregnancy may be associated with an elevated risk of adverse reproductive outcomes such as preterm birth. Maternal endocrine disruption across one pathway mediating some these relationships. We investigated whether urinary phthalate metabolites were maternal serum thyroid (free thyroxine [FT4], free triiodothyronine [FT3], and thyroid-stimulating hormone [TSH]), sex (estradiol, progesterone, hormone-binding globulin...
Phthalate exposure has been associated with a wide range of adverse health outcomes in limited epidemiologic studies, and inflammation oxidative stress have hypothesized as potential mechanisms involved. In the present study we investigated associations between urinary concentrations phthalate metabolites blood markers (bilirubin) (alkaline phosphatase [ALP], absolute neutrophil count [ANC], ferritin [adjusted for iron status], fibrinogen), using data from 10,026 participants National Health...
As public awareness of consequences environmental exposures has grown, estimating the adverse health effects due to simultaneous exposure multiple pollutants is an important topic explore. The challenges evaluating impacts factors in a multipollutant model include, but are not limited to: identification most critical components pollutant mixture, examination potential interaction effects, and attribution individual presence multicollinearity. In this paper, we reviewed five methods available...
Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy development of the fetus. The purpose this exploratory study was examine urinary PAH metabolites in potential association with mediators these outcomes. To do so, we measured a panel 12 inflammatory, angiogenic, oxidative stress biomarkers plasma or urine from women their third trimester (n = 200). Urinary were highly detectable (>88%) population, most higher who had lower...
Preeclampsia represents a major cause of maternal mortality and morbidity worldwide. Although it is known that the placenta plays central role in development preeclampsia, investigation into contribution environmental toxicants to risk preeclampsia has been sparse.In present study we examined relationship between longitudinally measured urinary BPA phthalate metabolite concentrations during gestation preeclampsia.A nested case-control preterm birth was performed 2011 from women enrolled...
Mediation analysis is useful for understanding mechanisms and has been used minimally in the study of environment disease.We examined mediation association between phthalate exposure during pregnancy preterm birth by oxidative stress.This nested case-control (n = 130 cases, 352 controls) included women who delivered Boston, Massachusestts, from 2006 through 2008. Phthalate metabolites 8-isoprostane, an stress biomarker, were measured urine three visits pregnancy. We applied four...
Exposure to environmental chemicals such as phthalates has been linked numerous adverse pregnancy outcomes, potentially through an oxidative stress mediated mechanism. Most research examined urinary 8-iso-prostaglandin F