A5083733382- Bone health and osteoporosis research
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Body Composition Measurement Techniques
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Thyroid Disorders and Treatments
- Frailty in Older Adults
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- Bone health and treatments
- Nutritional Studies and Diet
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biomarkers in Disease Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Diet and metabolism studies
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Genomic variations and chromosomal abnormalities
- SARS-CoV-2 and COVID-19 Research
- FOXO transcription factor regulation
- Sodium Intake and Health
Hong Kong Polytechnic University
2020-2025
University of Hong Kong
2007-2024
Chinese University of Hong Kong
2007-2020
Queen Mary Hospital
2020
Central China Normal University
2011
Nanfang Hospital
2008
Hong Kong Metropolitan University
2007
Sun Yat-sen University
2007
Sun Yat-sen University Cancer Center
2007
East China Normal University
2007
The aim of this meta-analysis is to comprehensively evaluate the effects lean mass on all-cause mortality across different cancer types.This a meta-analysis. Cohort studies and published before December 20, 2017 were obtained by systematic search PubMed, Cochrane Library, Embase. Inclusion criteria cohort reporting measurements dual-energy X-ray absorptiometry, bioimpedance analysis or computed tomography, with as study outcome. Exclusion using muscle surrogates, anthropometric measurement...
Abstract Background Low-density lipoprotein cholesterol (LDL-C) is suggested to play a role in osteoporosis but its association with bone metabolism remains unclear. Effects of LDL-C-lowering drugs on are also controversial. We aim determine whether LDL-C linked causally mineral density (BMD) and assess the effects BMD. Methods Association between blood lipid levels BMD was examined by epidemiological observation analyses US representative cohort NHANES III (n = 3638) Hong Kong Osteoporosis...
Osteoporosis, a disease characterized by low bone mineral density (BMD), increases the risk for fractures. Conventional factors alone do not completely explain measured BMD or osteoporotic fracture risk. Metabolomics may provide additional information. We aim to identify BMD-associated metabolomic markers that are predictive of assessed 209 plasma metabolites liquid chromatography with tandem mass spectrometry (LC-MS/MS) in 1552 Framingham Offspring Study participants, and femoral neck (FN)...
Sarcopenia is recognized to be a health problem which as serious obesity, but its relevance mortality unclear. We conducted meta-analysis of cohort studies on lean mass and in populations with different conditions. In this study, systematic search PubMed, Cochrane Library Embase was performed for published before Dec 20, 2017 examined the relationship between mortality. included reporting measurement by dual-energy X-ray absorptiometry, bioimpedance analysis or computed tomography,...
Severe COVID-19 has a poor prognosis, while the genetic mechanism underlying severe remains largely unknown. We aimed to identify genes that are potentially causally associated with COVID-19. conducted summary data-based Mendelian randomization (SMR) analysis using expression quantitative trait loci (eQTL) data from 49 different tissues as exposure and three COVID-19-phenotypes (very respiratory confirmed [severe COVID-19], hospitalized COVID-19, SARS-CoV-2 infection) outcomes. SMR multiple...
Accumulating evidence suggests the interaction of bone metabolism and immune system, but how health is associated with risk infections remains unknown.This study aimed to investigate relationship mineral density (BMD) common sepsis in Hong Kong Osteoporosis Study (HKOS). A prospective cohort study, initiated 1995 followed until 31 December 2020, 5,717 participants examined association BMD at three skeletal sites (lumbar spine, femoral neck, total hip) - pneumonia, urinary tract infection...
The size of the human head is highly heritable, but genetic drivers its variation within general population remain unmapped. We perform a genome-wide association study on (N = 80,890) and identify 67 loci, which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, most have widespread effects. Gene set enrichment observed for various cancers p53, Wnt, ErbB signaling pathways. Genes harboring lead enriched macrocephaly syndrome genes (37-fold) high-fidelity...
Abstract Background Inconsistent associations between coffee consumption and bone mineral density (BMD) have been observed in epidemiological studies. Moreover, the relationship of bioactive components with BMD has not studied. The aim current study is to identify coffee-associated metabolites evaluate their association BMD. Methods Two independent cohorts totaling 564 healthy community-dwelling adults from Hong Kong Osteoporosis Study (HKOS) who visited 2001–2010 (N = 329) 2015–2016 235)...
Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it promising therapeutic target for cardiometabolic diseases and anorexia/cachexia. Although many pharmaceutical companies are developing drugs targeting GFRAL, whether the findings from animal can be extrapolated to man unknown. Mendelian...
Hip fracture is associated with immobility, morbidity, mortality, and high medical cost. Due to limited availability of dual-energy X-ray absorptiometry (DXA), hip prediction models without using bone mineral density (BMD) data are essential. We aimed develop validate 10-year sex-specific electronic health records (EHR) BMD.In this retrospective, population-based cohort study, anonymized were retrieved from the Clinical Data Analysis Reporting System for public healthcare service users in...
Recently, a series of gold(III) meso-tetraarylporphyrins that are stable against demetallation in physiological conditions have been synthesized. In the present study, antitumor effects one these compounds, meso-tetraarylporphyrin 1a (gold-1a) was investigated an orthotopic rat hepatocellular carcinoma (HCC) model as well using HCC cell line. The induced by injection hepatoma cells, McA-RH7777, into left lobe liver. Seven days after tumor inoculation, gold-1a injected directly nodule at...
ABSTRACT The objective of this work was to study the risk pneumonia and mortality among patients receiving nitrogen-containing bisphosphonates (N-BPs), non-N-BP anti-osteoporosis medications, no medications after hip fracture. We studied a historical cohort using population-wide database. Patients with first fracture during 2005–2015 were identified matched by time-dependent propensity score. followed until December 31, 2016, capture any mortality. Hazard ratios (HRs) 95% confidence...
BackgroundMedian survival for patients with glioblastoma multiforme, the most aggressive glioma, is only 12–15 months, despite multimodal treatment that includes surgery, chemotherapy, and radiotherapy. Thus, identification of genes control progression multiforme crucial devising new therapies. We investigated involvement cell cycle–related kinase (CCRK), a novel protein homologous to cyclin-dependent 7, in carcinogenesis.
The role of serum calcium in bone metabolism is unknown, even though calcium/vitamin D supplementations have been widely used and are expected to improve health. We aim determine the independent mineral density (BMD).Two epidemiological analyses with 5478 5556 participants from National Health Nutrition Examination Survey (NHANES) 2003 2006 Hong Kong Osteoporosis Study (HKOS) evaluate cross-sectional association BMD. Two-sample Mendelian randomization (MR) studies using genetic variations as...
Large electronic medical record (EMR) databases can facilitate epidemiology research into uncommon diseases such as interstitial lung disease (ILD). Given the rarity and diagnostic difficulty of ILD, validity coding in EMR requires clarification. We aimed to assess International Classification Diseases, 9th Revision (ICD-9) code algorithms for identifying ILD territory-wide health system Clinical Data Analysis Reporting System (CDARS) Hong Kong.Patients who visited Queen Mary Hospital...
ABSTRACT Preclinical studies demonstrated that bone plays a central role in energy metabolism. However, how metabolism is related to the risk of diabetes humans unknown. We investigated association health (bone mineral density [BMD] and turnover markers) with incident type-2 mellitus (T2DM) based on Hong Kong Osteoporosis Study (HKOS). A total 993 7160 participants from HKOS were studied for cross-sectional prospective analyses, respectively. The study evaluated BMD biomarkers fasting...
Abstract Purpose Cancer-related genes and pathways have recently been implicated in a genome-wide meta-analysis of head size. In the current study, we aimed to evaluate association between adult circumference risk cancer. Methods This is cohort study using data from Hong Kong Osteoporosis Study, where 1,301 participants aged 27–96 years with measured 2015 2019, without history cancer, were followed up 15 January 2024. Incident cancers identified electronic medical records territory-wide...
Sarcopenia has been an emerging theme in clinical oncology. Various definitions of sarcopenia have proposed, but their prognostic performance yet to be evaluated and compared. The aim this meta-analysis is comprehensively evaluate the different cutoff cancer mortality prognostication. This a meta-analysis. Cohort studies on lean mass published before December 20, 2017 were obtained by systematic search PubMed, Cochrane Library, Embase. Inclusion criteria cohort reporting binary categorized...
Abstract This study aimed to evaluate the host genetic liability of coronavirus disease 2019 (covid‐19) with platelet traits using Mendelian randomization (MR) approach. We conducted a bidirectional two‐sample MR summary statistics from largest genome‐wide association three variables, covid‐19 severity (severe acute respiratory syndrome 2 [SARS‐CoV‐2] infection, hospitalization, and severe covid‐19, N = ~1 059 456–1 557 411) four (mean volume [MPV], plateletcrit, distribution width, count;...