A5047554081- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Hip and Femur Fractures
- Genetic Associations and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- Bone health and treatments
- Vitamin D Research Studies
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Digestive system and related health
- Bone and Joint Diseases
- Hormonal and reproductive studies
- Folate and B Vitamins Research
- Biomarkers in Disease Mechanisms
- Liver Disease Diagnosis and Treatment
- Connective tissue disorders research
- Parathyroid Disorders and Treatments
- Birth, Development, and Health
- Ion channel regulation and function
- Nutritional Studies and Diet
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Menopause: Health Impacts and Treatments
University of Hong Kong
2009-2024
Chinese University of Hong Kong
1995-2023
Queen Mary Hospital
2003-2022
HKU-Pasteur Research Pole
2007-2009
Mayo Clinic
2008
The prevalence of chronic diseases has risen along with increased longevity. Co-occurrence two or more in an individual (multimorbidity) is prevalent and poses a huge burden to individuals the society. However, determinants multimorbidity are largely unknown. Handgrip strength general indicator muscle linked premature mortality. its role never been evaluated. To investigate relationships between handgrip multiple multimorbidity, assess usefulness age as marker community dwelling sample men...
Handgrip strength (HGS) is a potentially useful objective parameter to predict fracture since it an indicator of general muscle and associated with fragility propensity fall. Our was examine the association HGS fracture, evaluate accuracy in predicting incident identify subjects at risk fracture. We analyzed cross-sectional cohort 2,793 (1,217 men 1,576 women aged 50-101 years) subset 1,702 which were followed for total 4,855 person-years. The primary outcome measures prevalent fractures...
Independent risk factors for osteoporotic fracture were identified a Southern Chinese postmenopausal population. Clinical factor assessment with or without BMD measurement was shown to be an effective predictor of 10-yr and provides more accessible tool patient evaluation.Asian-specific data on osteoporosis remain sparse. However, assessment, in addition measurement, is increasingly recognized as reliable absolute risk. The purpose this prospective study determine the specific independent...
Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment the influence sequence variants other ethnicities. To determine whether markers that we recently shown to associate Bone Mineral Density (BMD) in Europeans also BMD East-Asians analysed 50 from 23 genomic loci samples Korea (n = 1,397) and two Chinese Hong Kong sample sets 3,869 n 785). Through this effort identified fourteen associated East-Asian using a false discovery rate...
Abstract Background Inconsistent associations between coffee consumption and bone mineral density (BMD) have been observed in epidemiological studies. Moreover, the relationship of bioactive components with BMD has not studied. The aim current study is to identify coffee-associated metabolites evaluate their association BMD. Methods Two independent cohorts totaling 564 healthy community-dwelling adults from Hong Kong Osteoporosis Study (HKOS) who visited 2001–2010 (N = 329) 2015–2016 235)...
Accumulating evidence suggests the interaction of bone metabolism and immune system, but how health is associated with risk infections remains unknown.This study aimed to investigate relationship mineral density (BMD) common sepsis in Hong Kong Osteoporosis Study (HKOS). A prospective cohort study, initiated 1995 followed until 31 December 2020, 5,717 participants examined association BMD at three skeletal sites (lumbar spine, femoral neck, total hip) - pneumonia, urinary tract infection...
Hip fracture is associated with immobility, morbidity, mortality, and high medical cost. Due to limited availability of dual-energy X-ray absorptiometry (DXA), hip prediction models without using bone mineral density (BMD) data are essential. We aimed develop validate 10-year sex-specific electronic health records (EHR) BMD.In this retrospective, population-based cohort study, anonymized were retrieved from the Clinical Data Analysis Reporting System for public healthcare service users in...
Abstract Because of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P < 0.001) concentrations apo(a), total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), apo B, but higher A-I compared age-matched...
Uncontrolled study has demonstrated the usefulness of somatostatin in tratment mild Graves' ophthalmopathy (GO). We performed a prospective to evaluate as compared corticosteroid treatment moderately severe GO. All patients were rendered euthyroid and observed for 3 months exclude spontaneous improvement without active treatment. They randomized receive either (SS, octreotide 200 μh q8h subcutaneously, n = 8) or (CS, prednisone 1 mg/kg/day decreasing doses, 10). Assessments soft tissue...
abstract To investigate the effect of thyroid dysfunction on high-density lipoprotein (HDL) metabolism, we measured HDL subfractions, apolipoprotein A-I containing particles (LpA-I and LpA-I:A-II), activities enzymes involved in remodeling metabolism HDL[ namely hepatic lipase (HL), lipase, cholesteryl ester transfer protein (CETP)] 18 hyperthyroid 17 hypothyroid patients before after treatment. was subfractionated by density gradient ultracentrifugation, LpA-I analyzed...
Although controversies exist on the possible adverse effect of T4 bone mass, most studies reported loss in estrogen-deprived postmenopausal women taking suppressive doses T4. We prospectively studied 46 with carcinoma thyroid for 2 yr to evaluate rate and assess whether calcium supplementation or without intranasal calcitonin was able decrease loss. All patients were receiving a stable dose L-T4 (170 +/- 60 micrograms/day 3.0 1.4 micrograms/kg.day) more than 1 yr. had TSH levels 0.03 mIU/L...
Abstract Sexual dimorphism in various bone phenotypes, including mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis bioinformatics network analysis. We conducted an genome-wide meta-analysis of interaction on lumbar spine (LS) femoral neck (FN) BMD...
Thyrotoxic (hypokalemic) periodic paralysis (TPP) is a frequent complication of thyrotoxicosis among Chinese men. To determine the genetic association TPP, we studied 97 male TPP patients, 77 Graves' disease patients without and 100 normal subjects. Mutations voltage-dependent calcium channel (Cav1.1), sodium (Nav1.4), potassium (Kv3.4), microsatellite markers on chromosome 1 in region Na/K-ATPase subunits α1, α2, β1 were studied. None carried known mutations Cav1.1, Nav1.4, Kv3.4 genes....
The role of serum calcium in bone metabolism is unknown, even though calcium/vitamin D supplementations have been widely used and are expected to improve health. We aim determine the independent mineral density (BMD).Two epidemiological analyses with 5478 5556 participants from National Health Nutrition Examination Survey (NHANES) 2003 2006 Hong Kong Osteoporosis Study (HKOS) evaluate cross-sectional association BMD. Two-sample Mendelian randomization (MR) studies using genetic variations as...
ABSTRACT Preclinical studies demonstrated that bone plays a central role in energy metabolism. However, how metabolism is related to the risk of diabetes humans unknown. We investigated association health (bone mineral density [BMD] and turnover markers) with incident type-2 mellitus (T2DM) based on Hong Kong Osteoporosis Study (HKOS). A total 993 7160 participants from HKOS were studied for cross-sectional prospective analyses, respectively. The study evaluated BMD biomarkers fasting...