A5003221758- Bone health and osteoporosis research
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Cardiovascular Health and Disease Prevention
- Vitamin K Research Studies
- Vitamin C and Antioxidants Research
- Hip and Femur Fractures
- Parathyroid Disorders and Treatments
- Nutrition, Genetics, and Disease
- Antioxidant Activity and Oxidative Stress
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Phytochemicals and Antioxidant Activities
- Aortic aneurysm repair treatments
- Diet and metabolism studies
- Bone and Joint Diseases
- Consumer Attitudes and Food Labeling
- Cerebrovascular and Carotid Artery Diseases
- Bone Metabolism and Diseases
- Sodium Intake and Health
- Genetic Associations and Epidemiology
- Neurological Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Body Composition Measurement Techniques
Edith Cowan University
2015-2025
The University of Western Australia
2016-2025
The University of Sydney
2016-2025
Royal Perth Hospital
2015-2025
Children's Hospital at Westmead
2016-2025
Hospital Research Foundation
2021-2025
University of Maryland, Baltimore
2018-2025
SUNY Upstate Medical University
2024
RPH Research Foundation
2022-2024
Innovation Research Center
2024
Abstract Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; on cancer mortality are scarce and moderating effects of lifestyle risk factors for early unknown. In this prospective cohort study including 56,048 participants the Danish Diet, Cancer, Health crosslinked nationwide registries followed 23 years, there 14,083 deaths. A moderate habitual intake flavonoids inversely associated all-cause,...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.
Abstract Activation of the mechanistic target rapamycin (mTOR) is a key metabolic checkpoint pro-inflammatory T-cell development that contributes to pathogenesis autoimmune diseases, such as systemic lupus erythematosus (SLE), however, underlying mechanisms remain poorly understood. Here, we identify functional role for Rab4A-directed endosome traffic in CD98 receptor recycling, mTOR activation, and accumulation mitochondria connect pathways with immune cell lineage pathogenesis. Based on...
Frailty is associated with declines in physiological capacity across sensory, neurological, and musculoskeletal systems. An underlying assumption that the frailer an individual, more likely they are to experience falls fractures. We examined whether grades of frailty can assess long-term risk hospitalized falls, fractures, all-cause mortality 1261 community-dwelling older women (mean age [SD] 75.1 [2.7] yr) over 14.5 yr. was operationalized using a index (FI) cumulative deficits from 33...
Abstract Vertebral fracture assessment (VFA) images from bone density machines enable the automated machine learning of abdominal aortic calcification (ML-AAC), a marker cardiovascular disease (CVD) risk. The objective this study was to describe risk major adverse event (MACE, linked health records) in patients attending routine mineral (BMD) testing and meeting specific criteria based on age, BMD, height loss, or glucocorticoid use have VFA Manitoba Bone Mineral Density Registry. cohort...
Concern has been expressed that calcium supplementation, a key intervention for preventing osteoporotic fracture in older women, may increase the risk of atherosclerotic vascular disease. To evaluate further, an examination complete verified hospitalization and mortality data from 5-year randomized, controlled trial (RCT) carbonate 4.5 years posttrial follow-up was undertaken. This study used published double-blinded, placebo-controlled [Calcium Intake Fracture Outcome Study (CAIFOS)]. The...
Abstract Daily vitamin D in addition to calcium supplementation reduces falls and fractures older women. However, poor adherence therapy is a common clinical problem. To examine the effects of supervised oral 3-monthly on falls, muscle strength, mobility, we conducted 9-month randomized, double-blind, placebo-controlled trial 686 community-dwelling ambulant women aged over 70 years. Participants received either cholecalciferol 150,000 IU every 3 months (n = 353) or an identical placebo 333)....
Abstract The clinical effects of calcium supplements on adverse events reporting have not been well described. This study reviews randomized controlled trial (RCT) evidence to clarify the epidemiology these events. hypothesis that patient self-report myocardial infarction (MI) is increased in individuals receiving supplementation because an increase non-MI incorrectly perceived by as being MI, examined. In seven RCTs summary self-reported gastrointestinal (GI) event rates were more common...
ABSTRACT Proton pump inhibitors (PPIs) are widely used in the elderly. Recent studies have suggested that long-term PPI therapy is associated with fractures elderly, however mechanism remains unknown. We investigated association between ≥1 year and fracture risk factors including bone structure, falls, balance-related function a post hoc analysis of longitudinal population-based prospective cohort elderly postmenopausal women replicated findings second study falling women. Long-term was...
The current allocation algorithm for deceased donor kidney transplantation takes into consideration HLA mismatches at the ABDR loci but not other loci, including HLA-DQ. However, independent effects of incompatibilities closely linked HLA-DQ antigens in context HLA-DR antigen matched and mismatched allografts are uncertain. We aimed to determine effect on renal allograft outcomes.Using data from Australia New Zealand Dialysis Transplant Registry, we examined association between acute...