A5088362417- Birth, Development, and Health
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Body Composition Measurement Techniques
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Frailty in Older Adults
- Breastfeeding Practices and Influences
- Bone health and osteoporosis research
- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Chronic Disease Management Strategies
- Muscle metabolism and nutrition
- Obesity and Health Practices
- Asthma and respiratory diseases
- Vitamin D Research Studies
- Fatty Acid Research and Health
- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Food Security and Health in Diverse Populations
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
NIHR Newcastle Biomedical Research Centre
2019-2025
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2023-2025
Newcastle University
1996-2025
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019-2025
University of Newcastle Australia
2020-2025
Clinical Research Institute
2024-2025
University of York
2025
Australian Institute for Musculoskeletal Science
2024
Western Health
2024
The University of Melbourne
2024
Abstract Background All proposed definitions of sarcopenia include the measurement muscle mass, but techniques and threshold values used vary. Indeed, literature does not establish consensus on best technique for measuring lean body mass. Thus, objective is hampered by limitations intrinsic to assessment tools. The aim this study was review methods assess mass reach development a reference standard. Methods Literature reviews were performed members European Society Clinical Economic Aspects...
<h3>Abstract</h3> <b>Objective</b>: To assess how nutrient intakes of mothers in early and late pregnancy influence placental fetal growth. <b>Design</b>: Prospective observational study. <b>Setting</b>: Princess Anne Maternity Hospital, Southampton. <b>Subjects</b>: 538 who delivered at term. <b>Main outcome measures</b>: Placental birth weights adjusted for the infant9s sex duration gestation. <b>Results</b>: Mothers had high carbohydrate babies with lower weights. Low maternal dairy meat...
Introduction: sarcopenia is associated with adverse health outcomes. The aim of this study was to describe the prevalence in community-dwelling older people UK using European Working Group on Sarcopenia Older People (EWGSOP) consensus definition. Methods: we applied EWGSOP definition 103 men participating Hertfordshire Study (HSS) both lowest third dual-energy X-ray absorptiometry (DXA) lean mass (LM) and skin-fold-based fat-free (FFM) as markers low muscle mass. We also used FFM approach...
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offspring's bone health in later life. To investigate whether affects fetal femur growth ways similar to those seen childhood rickets and study timing gestation of any effect status, we studied 424 pregnant women within a prospective longitudinal nutrition lifestyle before (Southampton Women's Survey). Using high-resolution 3D ultrasound, measured length distal metaphyseal cross-sectional...
Poor appetite is a common problem in older people living at home and care homes, as well hospital inpatients. It can contribute to weight loss nutritional deficiencies, associated poor healthcare outcomes, including increased mortality. Understanding the causes of reduced knowing how measure it will enable nurses other clinical staff working range community settings identify patients with impaired appetite. A strategies be used promote better increase food intake.
Sarcopenia is a generalised skeletal muscle disorder characterised by reduced strength and mass associated with range of negative health outcomes. Currently, resistance exercise (RE) recommended as the first-line treatment for counteracting deleterious consequences sarcopenia in older adults. However, whilst there considerable evidence demonstrating that RE an effective intervention improving function healthy adults, much less known about its benefits people living sarcopenia. Furthermore,...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
Inverse associations between birthweight and later risk of major chronic diseases, notably cardiovascular disease, diabetes, osteoporosis, have been found in various studies.1 Birthweight is determined by length gestation the combination early trajectory fetal growth capacity supply line to maintain this late gestation. Studies pregnancy, assisted reproductive technology, animal experiments indicate that both genetic environmental factors are important establishing line; include...
To examine the association between birth weight and body fat distribution in a group of adolescent girls.A total 216 white girls who were born Southampton had their heights, weights, waist hip circumferences, skinfold thicknesses measured when they aged 14 16 years.The smallest at birth, but fattest time measurement most centrally obese. In whose mass index was above median (21 kg/m2), subscapular to triceps ratio rose by 9% for every kilogram decrease weight. Among overweight girls, with...
OBJECTIVES: To examine relationships between diet and grip strength in older men women to determine whether prenatal growth modifies these relationships. DESIGN: Cross‐sectional retrospective cohort study. SETTING: Hertfordshire, United Kingdom. PARTICIPANTS: Two thousand nine hundred eighty‐three aged 59 73 who were born still living MEASUREMENTS: Weight at birth recorded Health Visitor ledgers; current food nutrient intake assessed using an administered frequency questionnaire; measured a...
A woman's life style choices before and during pregnancy have important implications for her unborn child, but information on behaviour can be unreliable when data are collected retrospectively. In particular there no large longitudinal datasets that include prospectively to allow accurate description of changes in into pregnancy. The Southampton Women's Survey is a study women Southampton, UK, characterised they were not pregnant again objective the analyses presented here describe degree...
It is not known what constitutes an optimal diet in infancy. There are relatively few studies of weaning practice the UK, and there a need for prospective data on effects infant nutrition health later life. We describe dietary patterns, defined using principal components analysis FFQ data, 1434 infants aged 6 12 months, born between 1999 2003. The two most important patterns identified at months were very similar. first pattern was characterised by high consumption fruit, vegetables...
Abstract Evidence is accumulating that intrauterine growth and development may influence an individual's risk of osteoporosis in later adult life. To examine maternal paternal influences on skeletal growth, we used dual-energy X-ray absorptiometry to measure the neonatal bone mineral content (BMC) density (BMD) 145 infants born at term. Independently infant's duration gestation birth, birthweights both parents height father were positively correlated with whole body BMC. Women who smoked...
Abstract Wilms tumor is genetically heterogeneous, and until recently only one gene was known, WT1 at 11p13. However, altered in ∼20% of tumors. Recently a novel gene, WTX Xq11.1, reported to be mutated No overlap between tumors with mutations noted, suggesting that could account for the genetic basis roughly half To assess frequency their relationship larger ( n = 125) panel which had been thoroughly assessed , we conducted complete mutational analysis included sequencing entire coding...