A5033034869- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Health disparities and outcomes
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Health Promotion and Cardiovascular Prevention
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical Economics and Policy
- Inflammatory mediators and NSAID effects
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Diet and metabolism studies
Monash University
2016-2025
Australian Regenerative Medicine Institute
2007-2024
The University of Western Australia
2007-2023
Hennepin Healthcare Research Institute
2023
The University of Adelaide
2010-2023
Curtin University
2011-2023
Berman Center for Outcomes and Clinical Research
2023
University of Iowa
2023
Rush University Medical Center
2023
University of Tasmania
2023
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in primary disease unclear, especially older persons, who have an increased risk.
In the primary analysis of Aspirin in Reducing Events Elderly (ASPREE) trial, now published Journal, we report that daily use aspirin did not provide a benefit with regard to end point disability-free survival among older adults. A numerically higher rate secondary death from any cause was observed than placebo.
Background— Diabetes mellitus increases the risk of cardiovascular disease (CVD) and all-cause mortality. The relationship between milder elevations blood glucose mortality is less clear. This study investigated whether impaired fasting tolerance, as well diabetes mellitus, increase CVD Methods Results— In 1999 to 2000, tolerance status was determined in 10 428 participants Australian Diabetes, Obesity, Lifestyle Study (AusDiab). After a median follow-up 5.2 years, 298 deaths occurred (88...
Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years daily low-dose therapy would extend disability-free seniors unclear.From 2010 through 2014, we enrolled community-dwelling Australia and United States who were 70 age or (or ≥65 among blacks Hispanics States) did not have cardiovascular disease, dementia, physical disability. Participants randomly assigned receive 100 mg per day enteric-coated placebo orally. The primary...
Abstract. There is abundant evidence that the risk of atherosclerotic vascular disease directly related to plasma cholesterol levels. Accordingly, all national and transnational screening therapeutic guidelines are based on total or LDL cholesterol. This presumes most important lipoprotein‐related proatherogenic variable. On contrary, appears be more number circulating atherogenic particles contact enter arterial wall than measured concentration in these lipoprotein fractions. Each contains...
1. Time domain summary statistics and frequency parameters can be used to measure heart rate variability. More recently, qualitative methods including the Poincaré plot have been evaluate The aim of this study was validate a novel method quantitative analysis using conventional statistical techniques. 2. Beat-to-beat variability measured over relatively short period time (10–20 min) in 12 healthy subjects aged between 20 40 years (mean 30 ± 7 years) during (i) supine rest, (ii) head-up tilt...
The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use an automated external defibrillator (AED) might offer opportunity improve survival for patients at risk.
Objective: To develop and validate a diabetes risk assessment tool for Australia based on demographic, lifestyle simple anthropometric measures. Design setting: 5-year follow-up (2004–2005) of the Australian Diabetes, Obesity Lifestyle study (AusDiab, 1999–2000). Participants: 6060 AusDiab participants aged 25 years or older who did not have diagnosed at baseline. Main outcome measures: Incident was defined by treatment with insulin oral hypoglycaemic agents fasting plasma glucose level ≥...
To develop and validate a diabetes risk assessment tool for Australia based on demographic, lifestyle simple anthropometric measures.5-year follow-up (2004-2005) of the Australian Diabetes, Obesity Lifestyle study (AusDiab, 1999-2000).6060 AusDiab participants aged 25 years or older who did not have diagnosed at baseline.Incident was defined by treatment with insulin oral hypoglycaemic agents fasting plasma glucose level > = 7.0 mmol/L 2-hour in an tolerance test 11.1 mmol/L. The prediction...
Abstract Aims Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially death. As phospholipids also linked with CVD risk, we investigated whether combination of ceramides phosphatidylcholines (PCs) would be synergistic in prediction events patients atherosclerotic coronary heart three independent cohort studies. Methods and results Ceramides PCs were analysed using liquid chromatography–mass spectrometry (LC-MS) studies: WECAC (The...
Epidemiological studies investigating the role of fine particulate matter (PM2.5; aerodynamic diameter <2.5 μm) in triggering acute coronary events, including out-of-hospital cardiac arrests and ischemic heart disease (IHD), during wildfires have been inconclusive.We examined associations arrests, IHD, myocardial infarction, angina (hospital admissions emergency department attendance) with PM2.5 concentrations 2006-2007 Victoria, Australia, using a time-stratified case-crossover study...
There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin Reducing Events the Elderly (ASPREE) is a placebo-controlled trial low-dose that will determine whether 5 years daily 100-mg enteric-coated extends disability-free and dementia-free life healthy population these benefits outweigh risks. Set care, this randomized double-blind has composite endpoint death, incident dementia or persistent physical disability. Participants aged 70+...
Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.
Previous trials have had insufficient numbers of coronary events to address definitively the effect lipid-modifying therapy on heart disease in subgroups patients with varying baseline characteristics.The data from 3 large randomized pravastatin 40 mg were pooled and analyzed use a prospectively defined protocol. Included 19 768 patients, 102 559 person-years follow-up, 2194 primary end points (coronary death or nonfatal myocardial infarction), 3717 expanded (primary point, CABG, PTCA)....