A5043015080- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury Research
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Function and Risk Factors
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Health, Environment, Cognitive Aging
- Tracheal and airway disorders
- Aortic Thrombus and Embolism
- Cardiovascular and Diving-Related Complications
- Neurological Disease Mechanisms and Treatments
Harborview Medical Center
2005-2025
University of Washington
2010-2025
Universitätsmedizin Greifswald
2025
University of Pittsburgh
2001-2024
The University of Melbourne
2019-2024
Boston University
2019-2024
Monash University
2024
The University of Texas Health Science Center at San Antonio
2024
University of Thessaly
2024
University of Iowa
2024
The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use an automated external defibrillator (AED) might offer opportunity improve survival for patients at risk.
Recent clinical studies have demonstrated that mild hypothermia (32 degrees C to 34 C) induced by surface cooling improves neurological outcome after resuscitation from out-of-hospital cardiac arrest. Results animal models suggest the effectiveness of could be improved if initiated as soon possible return spontaneous circulation. Infusion cold, intravenous fluid has been proposed a safe, effective, and inexpensive technique induce arrest.In 17 hospitalized survivors arrest, we determined...
PURPOSE: To determine the prevalence of clinically serious findings unrelated to stroke on cranial magnetic resonance (MR) images in a population community-dwelling elderly people. MATERIALS AND METHODS: Neuroradiologists reviewed MR 3,672 people aged 65 years and older who were enrolled longitudinal, population-based study cardiovascular cerebrovascular disease. The neuroradiologists alerted imaging field centers about potentially abnormalities. Clinical information was obtained from...
Our objective was to investigate the association between hypertension and concurrent impairments in mobility, cognition, mood; role of brain white matter hyperintensities mediating this association; impact these on disability mortality elderly hypertensive individuals.-Blood pressure, gait speed, digit symbol substitution test, Center for Epidemiological Studies Depression Scale were measured yearly (1992-1999) 4700 participants Cardiovascular Health Study (age: 74.7, 58% women, 17% blacks,...
<i>Background:</i> Gait variability is an index of how much gait parameters, such as step length, change from one to the next. increases with age and in individuals affected by cortical subcortical neurodegenerative conditions, it associated falls incident mobility disability. The brain anatomical correlates have not been studied high-functioning community-dwelling older adults. <i>Methods:</i> MRIs were assessed a cohort 331 men women (mean = 78.3 years) free stroke,...
Background and Purpose— To clarify the role of inflammation in pathogenesis small vessel disease brain, we investigated association between common variation C-reactive protein (CRP) interleukin (IL)-6 genes, plasma CRP IL6 levels, presence MRI-defined white matter lesions (WML) brain infarcts (BI) elderly participants Cardiovascular Health Study. Methods— Tag single nucleotide polymorphisms (SNPs) genes were selected from SeattleSNPs database. In cross-sectional analyses, logistic regression...
Heart failure (HF) is associated with cognitive impairment. However, we know little about the time course of change after HF diagnosis, importance comorbid atrial fibrillation, or role ejection fraction. We sought to determine associations incident rates decline and whether these differed by fibrillation status reduced versus preserved Participants were 4864 men women aged ≥65 years without a history free clinical stroke in CHS (Cardiovascular Health Study)-a community-based prospective...
To identify potential risk factors for and clinical manifestations of ventricular sulcal enlargement on cranial magnetic resonance imaging (MRI), 3,301 community-dwelling people 65 years or older without a history stroke transient ischemic attack underwent extensive standardized evaluations MRI. In the multivariate model, increased age white matter grade MRI were dominant grade. For grade, other than race, which non-Blacks had higher grades, models men women shared no factors. variables...
Little is known about the acute precipitants of ischemic stroke, although evidence suggests infections contribute to risk. We hypothesized that hospitalization for infection associated with short-term risk stroke.
To evaluate the quality of exposure data provided by proxy respondents, we used a dual interview protocol in case-control study subarachnoid hemorrhage. All control subjects and their respondents were interviewed (N = 283 control-proxy pairs), as cases who able to provide own information 68 case-proxy pairs). The reliability proxy-derived was excellent for demographic body habitus measures (kappa or intraclass correlation range 0.86–0.99), all aspects cigarette smoking history (range...
Ischemic strokes may accelerate long-term functional decline apart from their acute effects on neurologic function.To test whether the increase in disability is steeper after than before event for ischemic stroke but not myocardial infarction (MI).In population-based, prospective cohort Cardiovascular Health Study (1989-2013), longitudinal follow-up was conducted a mean (SD) of 13 (6.2) years. Follow-up data were used until September 1, 2013; analysis performed August 2013, to June 2016....
Background and Purpose— Limited data exist on the performance of revised Framingham Stroke Risk Score (R-FSRS) R-FSRS in conjunction with nontraditional risk markers. We compared R-FSRS, original FSRS, Pooled Cohort Equation for stroke prediction assessed improvement discrimination by Methods— Six thousand seven hundred twelve 6814 participants MESA (Multi-Ethnic Study Atherosclerosis) were included. Cox proportional hazard, area under curve, net reclassification improvement, integrated...
OBJECTIVE To examine the risk of parkinsonism related to lifetime occupational exposure pesticides among a cohort men, mostly orchardists, in Washington State. METHODS All 310 subjects this study had previously participated men occupationally exposed pesticides. Subjects were given structured neurological examination and completed self administered questionnaire which elicited detailed information on pesticide (insecticide, herbicide, fungicide) use throughout their working careers....
To examine whether ingestion of aspartame is associated with headaches, we conducted a double-blind crossover study using volunteers self-identified headaches after aspartame. Of the 32 subjects randomized to receive (approximately 30 mg/kg/d) and placebo in two-treatment, four-period design, 18 completed full protocol, seven part protocol before withdrawing due adverse effects, three withdrew for other reasons, two were lost follow-up, one was withdrawn noncompliance, gave no reason. Each...
To examine the utility of somatosensory evoked potential (SEP) peaks and CSF creatine kinase BB isoenzyme activity (CKBB) in predicting nonawakening from coma due to cardiac arrest.Accurate predictors neurologic outcome patients comatose after arrest are needed improve medical decision making.A total 72 had bilateral median SEPs, these, 52 CKBB. Awakening was defined as following commands or having comprehensible speech. Both short (N1) long (N3) latency SEP were analyzed. Nonparametric...
We evaluated the sexual function of 41 married men with Parkinson9s disease (PD) and its relation to age, severity PD, depression. used a group 29 arthritis for comparison. Total functioning categories desire, arousal, orgasm, satisfaction did not differ significantly between patients PD arthritis. For both arthritis, increased illness, depression were associated reduced function. These results suggest that dysfunction is common in but no more so than another chronic illness does involve...
Background and Purpose— Few studies have assessed post-glucose load measures of insulin resistance ischemic stroke risk, data are sparse for older adults. We investigated whether fasting were related to incident in nondiabetic, Methods— Participants men women the Cardiovascular Health Study, age 65+ years without prevalent diabetes or at baseline, followed 17 stroke. The Gutt sensitivity index was calculated from baseline body weight 2-hour postload glucose; a lower indicates higher...
Abstract INTRODUCTION Identification of Alzheimer's disease (AD) needs inexpensive, noninvasive biomarkers, with validation in all populations. METHODS We collected plasma markers older American Indian individuals: phosphorylated‐tau181 (pTau181); amyloid‐beta (Aβ) 40,42; glial fibrillary acidic protein (GFAP); and neurofilament light chain (NfL). Plasma were analyzed for discriminant properties cognitive status etiology using receiver operating characteristic (ROC) analysis. RESULTS...
<h3>Objective</h3> To characterize patterns of findings on cranial magnetic resonance imaging (MRI) the elderly using a statistical technique called cluster analysis. <h3>Subjects and Methods</h3> The Cardiovascular Health Study is population-based, longitudinal study 5888 people 65 years older. Of these, 3230 underwent MRI scans, which were coded for presence infarcts grades white matter, ventricles, sulci. Cluster analysis separated participants into 5 clusters based solely findings....
<h3>Objective</h3> To test the hypothesis that inflammatory marker plasma soluble CD14 (sCD14) associates with incident dementia and related endophenotypes in 2 community-based cohorts. <h3>Methods</h3> Our samples included prospective Framingham Heart Study (FHS) Cardiovascular Health (CHS) Plasma sCD14 was measured at baseline to incidence of dementia, domains cognitive function, MRI-defined brain volumes. Follow-up for occurred over a mean 10 years (SD 4) FHS 6 3) CHS. <h3>Results</h3> We...
Background: Approximately 50% of ischemic strokes in patients with cancer are classified as cryptogenic after standard evaluation. As and its treatments associated increased risk for atrial fibrillation (AF), the pathological substrate AF—atrial cardiopathy—could be underlying etiology some these cancer-related strokes. However, relationship between cardiopathy is uncertain. Methods: We conducted a post-hoc cross-sectional analysis baseline data collected from enrolled into ARCADIA trial...