A5064911759- Bone health and osteoporosis research
- Bone health and treatments
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin D Research Studies
- Medication Adherence and Compliance
- Hip disorders and treatments
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal Hormones and Disorders
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Estrogen and related hormone effects
- Opioid Use Disorder Treatment
- Rheumatoid Arthritis Research and Therapies
- Meta-analysis and systematic reviews
- Cancer Diagnosis and Treatment
- Reliability and Agreement in Measurement
- Nutrition and Health in Aging
- Statistical Methods in Clinical Trials
Cedars-Sinai Medical Center
2016-2025
University of California, Los Angeles
2013-2023
Bone Health and Osteoporosis Foundation
1992-2023
University of Namur
2023
Pfizer (United States)
2016-2022
Analysis Group (United States)
2022
Eli Lilly (United States)
2008-2022
Pfizer (United Kingdom)
2022
Los Angeles Medical Center
2019-2021
American Society for Bone and Mineral Research
2020
Osteoporosis causes an elevated fracture risk. We propose the continued use of T-scores as one means for diagnosis but recommend that, alternatively, hip fracture; osteopenia-associated vertebral, proximal humerus, pelvis, or some wrist fractures; FRAX scores with ≥3 % (hip) 20 (major) 10-year risk also confer osteoporosis diagnosis. is a common disorder reduced bone strength that predisposes to increased fractures in older individuals. In USA, standard criterion postmenopausal women and men...
To assess the cost-effectiveness of interventions to prevent osteoporosis, it is necessary estimate total health care expenditures for treatment osteoporotic fractures. Resources utilized many diseases can be estimated from secondary databases using relevant diagnosis codes, but such codes do not indicate which fractures are in nature. Therefore, a panel experts was convened make judgments about probabilities that different types might related osteoporosis according patient age, gender, and...
Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize interventions in a given sequence. The objective was to develop algorithm recommendation that is easier interpret prescribing physician based on available and applicable Europe internationally. knee used as model OA joint.ESCEO assembled task force of 13 international experts (rheumatologists, clinical epidemiologists, scientists). were reviewed; all listed recent...
Abstract In this 3-yr, randomized, double-blind, placebo- and active-controlled study, healthy postmenopausal women with osteoporosis (55–85 yr of age) were treated bazedoxifene 20 or 40 mg/d, raloxifene 60 placebo. The primary endpoint was incidence new vertebral fractures after 36 mo; secondary endpoints included nonvertebral fractures, BMD, bone turnover markers. Among 6847 subjects in the intent-to-treat population, significantly lower (p < 0.05) mg (2.3%), (2.5%), (2.3%) compared...
Abstract Objective . To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective for the treatment active psoriatic arthritis (PsA) resistant to nonsteroidal antiinflammatory drug therapy. Methods Two hundred twenty‐one patients with PsA were recruited from 15 clinics, randomized (double‐blind) SSZ or placebo treatment, and followed up 36 weeks. Treatment response was based on joint pain/tenderness swelling scores physician patient global assessments. Results...
Abstract Bisphosphonates reduce the rate of osteoporotic fractures in clinical trials and community practice. “Atypical” nontraumatic diaphyseal (subtrochanteric or shaft) part femur have been observed patients taking bisphosphonates. We calculated incidence these within a defined population examined rates according to duration bisphosphonate use. identified all from January 1, 2007 until December 31, 2011 1,835,116 older than 45 years who were enrolled Healthy Bones Program at Kaiser...
Fragility fractures are common, affecting almost one in two older women and three men. Every fragility fracture signals increased risk of future as well premature mortality. Despite the major health care impact worldwide, currently there few systems place to identify "capture" individuals after a ensure appropriate assessment treatment (according national guidelines) reduce adverse outcomes. The Task Force reviewed current evidence about different systematic interventional approaches, their...
Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has been developed overcome this problem.To confirm the 1 year results provide more extensive safety tolerability information for once-monthly by a 2 analysis.MOBILE, randomised, phase III, non-inferiority study, compared efficacy of with daily ibandronate, which previously shown reduce vertebral fracture risk...
There is an important need to evaluate therapeutic approaches for osteoarthritis (OA) in terms of cost-effectiveness as well efficacy. The ESCEO expert working group met discuss the epidemiological and economic evidence that justifies increasing concern impact this disease reviewed current state-of-the-art health studies field. OA a debilitating disease; it frequency associated with substantial growing burden on society, both illness cost illness. Economic evaluations field are relatively...
To examine the effect of both prevalent and incident vertebral fractures on health-related quality life (HRQOL) in postmenopausal women with osteoporosis to characterize HRQOL respect number, location, severity, adjacency.Participants were a subset (n = 1,395, mean age 68.5 years) from Multiple Outcomes Raloxifene Evaluation trial who had low bone mineral density and/or fractures. Vertebral measured by radiography at baseline, 2 years, 3 years. was assessed using Osteoporosis Assessment...
To measure soluble factors having a possible role in fibromyalgia (FM) and compare the profiles of patients with recent onset syndrome chronic FM.The production cytokines, cytokine-related molecules, CXC chemokine, interleukin (IL)-8, was examined. Fifty-six FM (23 <2 yr 33 >2 symptoms) were compared age- sex-matched healthy controls. Cytokines molecules measured sera supernatants peripheral blood mononuclear cells (PBMC) that incubated without lectins phorbol myristate acetate (PMA).No...
We examined the incidence of hip fracture in Non-Hispanic White, Hispanic, Black, and Asian Americans for years 1983 1984 using a data base which contains summary all hospitalizations State California. found consistently lower risk after age 60 American females than White who were not Hispanic. Overall age-adjusted rates 49.7, 57.3, 85.4, respectively, 140.7/100,000 These differences males, although Whites (not Hispanic) had highest fractures among males.
Abstract Objective . To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective for the treatment active ankylosing spondylitis (AS) that not controlled with nonsteroidal antiinflammatory drug therapy. Methods Two hundred sixty‐four patients AS were recruited from 15 clinics, randomized (double‐blind) to SSZ or placebo treatment, and followed up 36 weeks. Treatment response was based on morning stiffness, back pain, physician patient global assessments. Results While...
Abstract Previous fractures of the hip, spine, or wrist are well-recognized predictors future fracture, but role other fracture sites is less clear. We sought to assess relationship between prior at 10 skeletal locations and incident fracture. The Global Longitudinal Study Osteoporosis in Women (GLOW) an observational cohort study being conducted 17 physician practices countries. aged ≥55 years answered questionnaires baseline 1 and/or 2 (fractures previous year). Of 60,393 women enrolled,...