A5080344590- Rheumatoid Arthritis Research and Therapies
- Microbial infections and disease research
- Water resources management and optimization
- Herpesvirus Infections and Treatments
- Climate Change Policy and Economics
- Economic and Environmental Valuation
- Systemic Lupus Erythematosus Research
- Global Energy and Sustainability Research
- Inflammatory mediators and NSAID effects
- Drug-Induced Adverse Reactions
- Child Nutrition and Water Access
- Orthopedic Infections and Treatments
- Toxoplasma gondii Research Studies
- Education, sociology, and vocational training
- Spondyloarthritis Studies and Treatments
- Aquaculture disease management and microbiota
- Autoimmune and Inflammatory Disorders Research
- Animal Virus Infections Studies
- Quinazolinone synthesis and applications
- Energy, Environment, and Transportation Policies
- Social Sciences and Governance
- Water Governance and Infrastructure
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Forest Management and Policy
Queen Victoria Hospital
2023
Université Sorbonne Paris Nord
2021
Vivid Economics (United Kingdom)
2011-2020
Bowdoin College
2020
Futures Group (United States)
2016-2017
University of Cape Town
2017
University of Ghana
2017
Kenya Institute for Public Policy Research and Analysis
2017
University College London
2017
Institute of Development Studies
2017
One hundred eighty-nine patients with rheumatoid arthritis were entered into a prospective, controlled, double-blind multicenter trial comparing placebo and methotrexate (MTX). ten completed 18 weeks of therapy. No remissions seen, but able to tolerate low-dose pulse MTX therapy significantly improved, compared receiving therapy, for all clinical variables measured, including joint pain/tenderness swelling counts, nodules, patient physician assessment disease activity. treatment demonstrated...
Abstract Objective . To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective for the treatment active psoriatic arthritis (PsA) resistant to nonsteroidal antiinflammatory drug therapy. Methods Two hundred twenty‐one patients with PsA were recruited from 15 clinics, randomized (double‐blind) SSZ or placebo treatment, and followed up 36 weeks. Treatment response was based on joint pain/tenderness swelling scores physician patient global assessments. Results...
Abstract Thirty‐seven patients with psoriatic arthritis were entered into a 12‐week prospective, controlled, double‐blind multicenter trial comparing placebo and oral pulse methotrexate therapy. Methotrexate was given in dose of 2.5—5.0 mg every 12 hours 3 consecutive doses per week. A stable background medication program nonsteroidal antiinflammatory drugs allowed. superior to only physician assessment activity improvement the amount skin surface area psoriasis. small but statistically...
Abstract A composite index for estimating improvement in individual rheumatoid arthritis (RA) patients during trials of slow‐acting, disease‐modifying antirheumatic drugs (DMARDs) was developed by analyzing the responses 130 placebo‐treated participants Cooperative Systematic Studies Rheumatic Diseases studies. If 4 6 selected measures were required (by ⩾20% morning stiffness, Westergren erythrocyte sedimentation rate, joint pain/tenderness score, and swelling ⩾2 grades on a 5‐grade scale,...
Abstract Objective. To compare the relative safety and efficacy of naproxen acetaminophen in treatment osteoarthritis (OA) knee. The major outcome measures were radiographic progression withdrawal from trial due to lack efficacy. Methods. One hundred seventy‐eight patients with OA knee enrolled a 2‐year prospective, controlled, double‐blind multicenter randomly assigned receive (ACT) or (NPX) treatment. Results. After 6 weeks treatment, modest improvement pain on motion physician's global...
A historical cohort study evaluated the mortality experience of 26,561 workers employed in 10 formaldehydeproducing or -using facilities. Approximately 600,000 person-years follow-up accrued as were followed to January 1, 1980. Estimates exposure formaldehyde by job developed project industrial hygienists using monitoring data available from participating plants, comments long-term workers, and comprehensive specifically collected for this study. Mortality all causes combined was about...
Abstract Objective . To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective for the treatment active ankylosing spondylitis (AS) that not controlled with nonsteroidal antiinflammatory drug therapy. Methods Two hundred sixty‐four patients AS were recruited from 15 clinics, randomized (double‐blind) to SSZ or placebo treatment, and followed up 36 weeks. Treatment response was based on morning stiffness, back pain, physician patient global assessments. Results While...
Abstract A prospective controlled, double‐blind multi‐center trial compared placebo, auranofin (an orally administered gold complex), and parenteral sodium thiomalate (GST) in patients with active rheumatoid arthritis (RA). Of 193 who received any treatment, the only important improvement identified for either or GST was pain/tenderness scores. When 161 completed 20 weeks of treatment were examined, both treatments superior to placebo as measured by number painful and/or tender joints, joint...
Abstract Objective. To compare the relative safety and efficacy of auranofin (AUR), metbotrexate (MTX), combination both in treatment active rheumatoid arthritis (RA). Methods. Three hundred thirty‐five patients with RA were entered into a 48‐week, prospective, controlled, double‐blind, multicenter trial randomly assigned to 1 3 groups. Results. Two eleven completed trial. No remissions seen, there no statistically significant differences among groups clinical or laboratory variables...
Abstract Acute suppurative arthritis is a form of joint disease demanding prompt diagnosis and therapy. Twenty‐four cases are reviewed, it suggested that in addition to clinical findings, analysis synovial fluid essential. Synovial leukocyte count greater than 50,000 cells per cu. mm., with 90 cent or more polymorphonuclear leukocytes fluid‐blood sugar difference over 40 mg. all support the diagnosis. Adequate treatment consists early therapy systemic antibacterial agents, repeated needle...
Abstract Objective . To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. Methods One hundred thirty‐four patients with ReA who had failed respond NSAIDs were recruited from 19 clinics, randomized (double‐blind) receive either SSZ or placebo, and followed up for 36 weeks. The definition response was based on joint pain/tenderness swelling...
Depression is common in rheumatoid arthritis (RA) populations and has been hypothesized to result from patients' belief that they cannot control their disease or its impact. In a sample of 106 patients with RA, we found scores on measure helplessness mediated the relationship between severe, disabling RA depression. Further, this association was independent previously demonstrated correlation cognitive distortion depression patients. Thus, both may be important factors development treatment among
Abstract In a sample of 107 patients with classic or definite rheumatoid arthritis (RA), we examined the convergent and divergent validity measures disability depression. Scores on self‐report Disability index Health Assessment Questionnaire were highly correlated physical therapist spouse ratings disability. Although scores significantly self‐reported interviewer‐assessed depression, these correlations smaller. Factor analyses Beck Depression Inventory (BDI) rheumatologist BDI items...
Abstract One hundred eighty‐six patients with active rheumatoid arthritis were evaluated in a double‐blind, randomized study that compared treatment sulfasalazine (SSZ) (2 gm/day), gold sodium thiomalate (GST) (50 mg/week), and placebo (PBO). The 37—week course of therapy was completed by 109 patients. While marked improvement seen all 3 groups, the only statistically significant differences between SSZ or GST PBO decreased erythrocyte sedimentation rate increased grip strength right hand....