José A. Riancho

ORCID: 0000-0003-0691-8755
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About
Contact & Profiles
Research Areas
  • Bone health and osteoporosis research
  • Bone Metabolism and Diseases
  • Bone health and treatments
  • Epigenetics and DNA Methylation
  • Estrogen and related hormone effects
  • Cancer Genomics and Diagnostics
  • Parathyroid Disorders and Treatments
  • Vitamin D Research Studies
  • Genetic Associations and Epidemiology
  • Forensic and Genetic Research
  • Molecular Biology Techniques and Applications
  • Cancer-related gene regulation
  • Mesenchymal stem cell research
  • MicroRNA in disease regulation
  • Genetic factors in colorectal cancer
  • Wnt/β-catenin signaling in development and cancer
  • Alkaline Phosphatase Research Studies
  • Osteoarthritis Treatment and Mechanisms
  • COVID-19 Clinical Research Studies
  • Bone and Joint Diseases
  • RNA modifications and cancer
  • Liver Disease Diagnosis and Treatment
  • Birth, Development, and Health
  • Folate and B Vitamins Research
  • Genetic Syndromes and Imprinting

Marqués de Valdecilla University Hospital
2016-2025

Universidad de Cantabria
2016-2025

Instituto de Investigación Marqués de Valdecilla
2016-2025

Centre for Biomedical Network Research on Rare Diseases
2023-2025

Instituto de Salud Carlos III
2024-2025

Instituto de Investigación de Enfermedades Raras
2024

Centro de Investigación Biomédica en Red
2023-2024

University of Toronto
2024

Complejo Hospitalario Universitario de Albacete
2023

Hospital Universitario Infanta Cristina
2023

Methylating the Family Tree DNA sequences show a high level of similarities between humans and ancient hominids but degree to which there are differences methylated regions in their genomes that may explain phenotypic is unclear. Gokhman et al. (p. 523 , published online 17 April) demonstrate naturally degraded cytosines converted thymines can be used reconstruct methylomes. The results suggest methylation bone tissues modern set genes important for limb development.

10.1126/science.1250368 article EN Science 2014-04-18

Aging | doi:10.18632/aging.100742. Steve Horvath, Vei Mah, Ake T. Lu, Jennifer S. Woo, Oi-Wa Choi, Anna J. Jasinska, José A. Riancho, Spencer Tung, Natalie Coles, Jonathan Braun, Harry V. Vinters, L. Stephen Coles

10.18632/aging.100742 article EN cc-by Aging 2015-05-11

Peak bone mass attained after skeletal growth is a major determinant of the risk developing osteoporosis later in life, hence importance nutritional factors that contribute to gain during infancy and adolescence. An adequate supply vitamin D essential for normal homeostasis. This study was undertaken determine what levels are 25-hydroxyvitamin (25(OH)D) may be considered desirable children assess if maintain these throughout year. Vitamin metabolites parathyroid hormone (PTH) serum were...

10.1359/jbmr.1998.13.4.544 article EN Journal of Bone and Mineral Research 1998-04-01

To determine genome-wide methylation profiles of bone from patients with hip osteoarthritis (OA) and those osteoporotic (OP) fractures.Trabecular pieces were obtained the central part femoral head 27 fractures 26 OA. DNA was isolated, explored Illumina arrays. RNA extracted, pooled, deep-sequenced to obtain whole transcriptome. Differentially methylated regions identified, connections between genes differentially by pathway text-mining analyses.After quality control, 23,367 CpG sites (13,463...

10.1002/art.37753 article EN Arthritis & Rheumatism 2012-11-02

Abstract Sclerostin, encoded by the SOST gene, is a potent inhibitor of bone formation, produced osteocytes, not osteoblasts, but little known about molecular mechanisms controlling its expression. We aimed to test hypothesis that epigenetic mechanisms, specifically DNA methylation, modulate found two CpG-rich regions in SOST: region 1, located proximal promoter, and 2, around exon 1. qMSP pyrosequencing analysis methylation showed 2 was largely methylated all samples analyzed. In contrast,...

10.1002/jbmr.1491 article EN Journal of Bone and Mineral Research 2011-12-08

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks changes methylation adult stem cells during lifetime are still largely unknown. Here, profiling mesenchymal (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites aging. As sequences were marks. Most importantly, strongly active mark H3K4me1 suggesting...

10.1101/gr.169011.113 article EN cc-by-nc Genome Research 2014-09-30

Osteoblasts are specialized cells that form new bone and also indirectly influence resorption by producing factors modulate osteoclast differentiation. Although the methylation of CpG islands plays an important role in regulation gene expression, there is still scanty information about its human bone. The aim this study was to investigate on transcriptional levels two osteoblast-derived critical osteoclastogenesis: receptor activator nuclear factor NF-κB ligand (RANKL) soluble decoy...

10.4161/epi.7.1.18753 article EN Epigenetics 2012-01-01
Luis Corral‐Gudino Alberto Bahamonde Francisco Arnaiz-Revillas Julia Gómez-Barquero Jésica Abadía‐Otero and 69 more Carmen García‐Ibarbia Víctor Manuel Mora Cuesta Ana Cerezo-Hernández José L. Hernández Graciela López-Muñíz Fernando Hernández-Blanco José Manuel Cifrián José M. Olmos Miguel F. Carrascosa Luis Nieto María Carmen Fariñas José A. Riancho Alberto Bahamonde Fernando Hernández-Blanco Cristina Buelta-González Luis Antonio Marcos-Martínez Ana Martínez-Vidal Pilar R.l Dosantos-Gallego Jesús Pérez-Sagredo Silvia Sandomingo-Freire Rebeca Muñumer-Blázquez Antonio Paredes-Mogollo Elena Brague-Allegue Miguel F. Carrascosa Juan Luis García‐Rivero José A. Riancho José M. Olmos Carmen Fariñas José Manuel Cifrián Carmen García‐Ibarbia José L. Hernández Francisco Arnaiz-Revillas Víctor Manuel Mora Cuesta Sara Nieto Juan José Ruiz-Cubillán Arancha Bermúdez Javier Pardo Carlos Antonio Amado Diago A. Insunza Aritz Gil Teresa Diaz-Terán Marina Fayos Miguel A. Zabaleta Juan José Parra Luis Corral‐Gudino Julia Gómez-Barquero Jésica Abadía‐Otero Ana Cerezo-Hernández Graciela López-Muñíz Angela Ruíz-de-Temiño-de-la-Peña C. Ainhoa Arroyo-Domingo Javier Mena-Martín P. Miramontes-González Ana E Jiménez-Masa Luis Pastor-Mancisidor Tanía M Álvaro-de-Castro María Cruz Pérez-Panizo Tomás Ruíz Albi C Gema de-la-Colina-Rojo María Andrés-Calvo Andrea Crespo-Sedano Begoña Morejón-Huerta Laisa Socorro Briongos-Figuero Julio F Frutos-Arriba Javier Pagán-Buzo Miriam Gabella-Martín Marta Cobos-Siles Ana Gómez-García Luis Nieto

ABSTRACT Background We aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk developing Acute Respiratory Distress Syndrome (ARDS). Methods Multicentric, partially randomized, preference, open-label trial, including adults COVID-19 pneumonia, impaired gas exchange and biochemical evidence hyper-inflammation. Patients were assigned standard care (SOC), or SOC plus MP [40mg/12h 3 days, then 20mg/12h...

10.1101/2020.06.17.20133579 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-06-18

Nitric oxide synthases (NOS) are enzymes that produce nitric (NO) from L-arginine in a reaction yielding citrulline as coproduct. modulates the activity of wide variety cells, but little is known about its effects on bone cells. In present study we report NOS inhibitor NG-monomethyl-L-arginine (NMMA) induced dose-dependent inhibitory effect proliferation osteoblast-like cell lines MG63 and ROS 17/2.8. The was prevented by increasing concentrations medium NO donor sodium nitroprusside....

10.1002/jbmr.5650100315 article EN Journal of Bone and Mineral Research 1995-03-01

A collaborative work was carried out by the Spanish and Portuguese ISFG Working Group (GEP-ISFG) to estimate Y-STR mutation rates. Seventeen Y chromosome STR loci (DYS19, DYS385, DYS389I II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS460, DYS461, DYS635 [GATA C4], GATA H4, A10) were analyzed in a sample of 3,026 father/son pairs. Among 27,029 allele transfers, 54 mutations observed, with an overall rate across 17 1.998 × 10–3 (95% CI, 1.501 2.606 10–3). With just one...

10.1002/humu.20254 article EN Human Mutation 2005-10-11

<h3>Objectives</h3> The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed arcOGEN Consortium, UK-wide collaborative effort aiming to scan over 7500 cases in two-stage scan. Here report findings stage 1 interim analysis. <h3>Methods</h3> performed knee and hip 3177 4894 population-based controls from UK. Replication promising signals was carried out silico five further...

10.1136/ard.2010.141473 article EN Annals of the Rheumatic Diseases 2010-12-21

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes fragility fractures. The functional capacity human mesenchymal stem cells (hMSCs), precursors osteoblasts, may be compromised in elderly individuals, relation with epigenetic changes associated aging. However, role hMSCs pathogenesis osteoporosis is still unclear. Therefore, we aimed characterize genome-wide methylation gene expression signatures differentiation from patients hip We obtained femoral...

10.1080/15592294.2016.1271854 article EN Epigenetics 2016-12-19
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