A5020282852- Obstructive Sleep Apnea Research
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Climate Change and Health Impacts
- Stress and Burnout Research
- Long-Term Effects of COVID-19
- Health and Lifestyle Studies
- Public Health and Environmental Issues
- Tracheal and airway disorders
- Human Health and Disease
- Cardiovascular and Diving-Related Complications
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Occupational Health and Safety in Workplaces
- Noise Effects and Management
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Medical Imaging and Pathology Studies
- Workplace Health and Well-being
- T-cell and B-cell Immunology
- Healthcare professionals’ stress and burnout
- Hematopoietic Stem Cell Transplantation
- Restless Legs Syndrome Research
Hospital Universitario Río Hortega
2000-2025
Hospital Clínico Universitario de Valladolid
2012-2025
Universidad de Valladolid
2012-2020
Junta de Castilla y León
2019
Hospital Rio Carrion
2009
Complejo Asistencial Universitario de Palencia
2008
Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in samples but also blood, stool urine. Severe characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or load plasma associated severe response. Methods A total of 250 patients were recruited (50 outpatients, 100 hospitalized ward critically ill). Viral detection quantification was performed using droplet digital PCR, targeting the N1 N2...
ABSTRACT Background We aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk developing Acute Respiratory Distress Syndrome (ARDS). Methods Multicentric, partially randomized, preference, open-label trial, including adults COVID-19 pneumonia, impaired gas exchange and biochemical evidence hyper-inflammation. Patients were assigned standard care (SOC), or SOC plus MP [40mg/12h 3 days, then 20mg/12h...
Abstract The most appropriate physiological signals to develop simplified as well accurate screening tests for obstructive sleep apnoea (OSA) remain unknown. This study aimed at assessing whether joint analysis of at-home oximetry and airflow recordings by means machine-learning algorithms leads a significant diagnostic performance increase compared single-channel approaches. Consecutive patients showing moderate-to-high clinical suspicion OSA were involved. apnoea-hypopnoea index (AHI) from...
Abstract Introduction Veno-arterial extracorporeal membrane oxygenation support (VA-ECMO) is an effective therapy in refractory cardiogenic shock and cardiorespiratory arrest. Sex-related differences regarding presentation outcomes are not well stablished this scenario. Methods Descriptive, retrospective single-center study that includes all patients who required VA-ECMO between 2021 2023. The main objective was to compare clinical characteristics, evolution mortality both sexes. Results 78...
The efficacy and safety of high versus medium doses glucocorticoids for the treatment patients with COVID-19 has shown mixed outcomes in controlled trials observational studies. We aimed to evaluate effectiveness methylprednisolone 250 mg bolus dexamethasone 6 severe COVID-19.A randomised, open-label, trial was conducted between February August 2021 at four hospitals Spain. suspended after first interim analysis since investigators considered that continuing would be futile. Patients were...
The welfare state in whom we live the developed countries does that there arises need to look for tools are a faithful image of health population such as it is measurement quality life related health.The aim our study know (HRQOL) sanitary workers measure their status.For have realized cross-sectional, prospective and descriptive sample 542 selected by systematic sampling.The dependent variable was assessed HRQOL SF-36.This questionnaire assesses status across 7 scales (physical function,...
Abstract Background Severe COVID-19 is characterized by clinical and biological manifestations typically observed in sepsis. SARS-CoV-2 RNA commonly detected nasopharyngeal swabs, however viral can be found also peripheral blood other tissues. Whether systemic spreading of the virus or components plays a role pathogenesis sepsis-like disease severe currently unknown. Methods We determined association plasma with responses severity patients COVID-19. 250 confirmed infection were recruited (50...
Positional obstructive sleep apnea (POSA) is a major phenotype of apnea. Supine-predominant positional patients are frequently characterized by milder symptoms and less comorbidity due to lower age, body mass index, overall apnea-hypopnea index. However, the bradycardia-tachycardia pattern during apneic events known be more severe in supine position, which could affect cardiac regulation patients. This study aims at characterizing nocturnal heart rate modulation presence POSA order assess...
<b>Background:</b> A lot of studies reported a link between air pollutants and negative health effects, which leads to an increased hospital admissions outpatient visits. Several factors influence the exposure intra-urban pollution, such as traffic climate. <b>Aims-Objectives:</b> To assess influenceof on total respiratory-related in 1-year period Valladolid, Spain. <b>Methods:</b> Hospital our Pneumology service throughout 2015 were retrospectively analyzed. Correlations admissions,...
<b>Background.</b> The development of home-based screening tests in sleep apnoea-hypopnoea syndrome (SAHS) diagnosis is essential to increase the accessibility diagnostic facilities. Chronic obstructive pulmonary disease (COPD) very prevalent among SAHS patients. However, almost all studies assessing for excluded patients with COPD. <b>Objectives.</b> To assess influence suffering from COPD performance an at-home test moderate-to-severe based on automated analysis nocturnal oximetry by means...
We have analyzed through an epidemiological descriptive study with a sample of 806 workers, the prevalencia overweight / obesity in sanitary way. For it we use information obtained the history clinical labour our workers and the obtaining anthropometrics. We define as IMC> 25 obesity> 30. Them proved general percentages of overweight they are similar to described in the literature; for sexes, men sample present more than women spite of standardizing age (against...
<b>Background:</b> The association between obstructive sleep apnea (OSA) and arterial hypertension (AH) is not absolutely established. Both entities are considered complex polygenic diseases share common risk factors. Among genotypes, the apolipoprotein E gen (ApoE) has been widely analyzed. However, there no studies assessing role of ApoE in AH onset OSA patients. <b>Aims Objectives</b>. To assess link genotypes incidence a cohort patients suffering from during an 8-year follow-up....