A5015867325- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Blood groups and transfusion
- Respiratory viral infections research
- Vitamin C and Antioxidants Research
- COVID-19 and healthcare impacts
- Inflammation biomarkers and pathways
- Adrenal Hormones and Disorders
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hemodynamic Monitoring and Therapy
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
Universidad de Valladolid
2021-2025
Centro de Investigación Biomédica en Red
2022-2025
Instituto de Salud Carlos III
2022-2025
Centre for Biomedical Network Research on Rare Diseases
2021-2025
Hospital Universitario Río Hortega
2019-2024
Columbia University
2024
Hospital Clínico Universitario de Valladolid
2017-2022
Instituto de Investigación Biomédica de Salamanca
2019-2020
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2017-2019
Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in samples but also blood, stool urine. Severe characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or load plasma associated severe response. Methods A total of 250 patients were recruited (50 outpatients, 100 hospitalized ward critically ill). Viral detection quantification was performed using droplet digital PCR, targeting the N1 N2...
Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role response infections. A defective redox balance has been related viral developing massive induction of cell death provoked by oxidative stress. The aim this study is perform complete profile evaluation regarding antioxidant enzymes, total capacity and damage order characterize diagnosis severity disease.
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis oxidation/secretion in the a major feature NAFLD. Given lack non-invasive reliable methods for diagnosis non-alcoholic steatohepatitis (NASH), it important find serum markers are capable discriminating or defining patients with this stage NASH. Blood samples were obtained from 152...
Objectives: To quantify immunological dysfunction in surgical patients with presence/absence of sepsis using a droplet digital polymerase chain reaction (ddPCR) transcriptomic analysis. The study also aims to evaluate this approach for improving identification these patients. Background: Immune dysregulation is central event sepsis. Quantification the expression genes participating pathogenesis could represent new avenue improve its diagnosis. Methods: Expression 6 neutrophil protease ( MMP8...
Background: Intensive care unit-acquired pneumonia (ICU-AP) is a severe complication in patients admitted to the ICU. Lymphocytopenia marker of poor prognosis with community-acquired pneumonia, but its impact on ICU-AP unknown. We aimed evaluate whether lymphocytopenia an independent risk factor for mortality non-immunocompromised ICU-AP. Methods: Prospective observational cohort study from six ICUs 800-bed tertiary teaching hospital (2005 2016). Results: Of 473 included, 277 (59%) had...
Community-acquired pneumonia (CAP) is a frequent cause of death worldwide. As recently described, CAP shows different biological endotypes. Improving characterization these endotypes needed to optimize individualized treatment this disease. The potential value the leukogram assist prognosis in severe has not been previously addressed.A cohort 710 patients with admitted intensive care units (ICUs) at Hospital Mataró and Parc Taulí Sabadell was retrospectively analyzed. Patients were split...
Abstract Background Stratification of the severity infection is currently based on Sequential Organ Failure Assessment (SOFA) score, which difficult to calculate outside ICU. Biomarkers could help stratify in surgical patients. Methods Levels ten biomarkers indicating endothelial dysfunction, 22 emergency granulopoiesis, and six denoting neutrophil degranulation were compared three groups patients first 12 h after diagnosis at Spanish hospitals. Results There 100 with infection, 95 sepsis 57...
Abstract Background Despite growing interest in treatment strategies that limit oxygen exposure ICU patients, no studies have compared conservative with standard postsurgical patients sepsis/septic shock, although there are indications it may improve outcomes. It has been proven high partial pressure of arterial blood (PaO 2 ) reduces the rate surgical-wound infections and mortality under major surgery. The aim this study is to examine whether PaO associated risk death adult shock after...
Introduction Prevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis major surgery conditions associated with ARDS. We aimed to examine impact 60-day mortality. Methods performed a secondary analysis prospective observational study 454 patients who underwent admitted into single ICU. Patients were stratified two groups depending whether...
Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity non-septic shock. Extracellular vesicle-derived miRNAs may serve as biomarkers distinguish from shock, providing a more accurate diagnostic tool for postsurgical patients. This study aims identify extracellular miRNA signatures that differentiate in patients, potentially improving accuracy and decision-making. A multicentre, prospective was conducted on profiles Two cohorts were recruited...
Despite the high mortality and economic burden associated with acute respiratory distress syndrome (ARDS), role of chest radiograph (CXR) in ARDS diagnosis prognosis remains uncertain. The purpose this study is to elucidate clinical characteristics that distinguish patients from those without ARDS, especially where CXRs are indicative ARDS. Secondary analysis a prospective observational 454 postoperative septic under mechanical ventilation (MV). Patients were stratified two groups depending...
Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution COVID-19. an observational prospective study. primary endpoint was analyze between lipid peroxidation, lipid, inflammatory profiles COVID-19 patients. A multivariate regression analysis employed....
Background/Objectives: Cardiovascular disease (CVD) remains the leading cause of death worldwide, and effectiveness statin therapy is critically dependent on patient adherence persistence. The aim this study was to evaluate persistence in newly started previously treated patients, with reference cardiovascular prevention. Methods: A retrospective cohort conducted assess patients. Patients aged 18 years or older a claim from 1 January 2021 31 December 2023 were included. Adherence defined as...
Background High cytokine levels have been associated with severe COVID-19 disease. Although many studies performed, not of them include combinatorial analysis profiles through time. In this study we investigate the association certain and its evolution, mortality in SARS-CoV2 infection hospitalized patients. Methods Serum concentration 45 cytokines was determined 28 controls at day admission 108 patients disease first, third sixth admission. A principal component (PCA) performed to...
Following the SEPSIS-3 consensus, detection of organ failure as assessed by SOFA (Sequential Organ Failure Assessment) score, is mandatory to detect sepsis. Calculating outside Intensive Care Unit (ICU) challenging. The alternative in this scenario, quick SOFA, very specific but less sensible. Biomarkers could help presence secondary infection either ICU and non-ICU settings.We evaluated ability four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM)...
Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in patients to identify novel biomarkers. A discovery–validation study two independent prospective cohorts was performed. The discovery cohort included 136 and non-COVID-19 recruited consecutively from 24 March 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system...
This economic evaluation reports the total and per patient costs of inpatient care for COVID-19 in Spain 2020.
A noteworthy proportion of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have an indeterminate vibration-controlled transient elastography (VCTE). Among these patients, we aimed to identify candidates for MASLD treatment by diagnosing significant fibrosis.
Abstract Early recognition of sepsis is a key factor to improve survival this disease in surgical patients, since it allows prompt control the infectious source. Combining pro-inflammatory and immunosupression biomarkers could represent good strategy detection. Here we evaluated combination procalcitonin (PCT) with gene expression levels HLA-DRA detect cohort 154 patients (101 53 no infection). was quantified using droplet digital PCR, next-generation PCR technology. Area under receiver...