A5080949068- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diagnosis and treatment of tuberculosis
- Pancreatitis Pathology and Treatment
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Food composition and properties
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Meat and Animal Product Quality
- Acute Lymphoblastic Leukemia research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Metabolites in Food Biotechnology
- Seed and Plant Biochemistry
- COVID-19 and healthcare impacts
- Alcohol Consumption and Health Effects
- Parvovirus B19 Infection Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Urologic and reproductive health conditions
Hospital Clínico Universitario de Valladolid
2017-2024
Universidad de Valladolid
2017-2024
Hospital Universitario Río Hortega
2019
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis oxidation/secretion in the a major feature NAFLD. Given lack non-invasive reliable methods for diagnosis non-alcoholic steatohepatitis (NASH), it important find serum markers are capable discriminating or defining patients with this stage NASH. Blood samples were obtained from 152...
Summary Background There are limited data of ustekinumab administered according to the doses recommended in UNITI studies. Aim To assess real‐world, short‐term effectiveness refractory Crohn's disease (CD) Methods Multicentre study CD patients starting after June 2017 at recommend dose (260, 390 or 520 mg based on weight ~6 mg/kg IV week 0 and 90 subcutaneously 8). Values for Harvey‐Bradshaw Index (HBI), C‐reactive protein (CRP) faecal calprotectin (FC) were recorded baseline weeks 8 14....
Summary Background Data on the long‐term administration of ustekinumab in recommended doses are limited. Aim To assess real‐world, effectiveness refractory Crohn's disease (CD). Methods Multi‐centre study CD patients starting at dose, followed for 1 year. Values Harvey‐Bradshaw Index (HBI), endoscopic activity, C‐reactive protein (CRP), and faecal calprotectin (FC) were recorded baseline weeks 26 52. Demographic clinical data, previous treatments, adverse events (AEs) hospitalisations...
Swine farming produces large quantities of nutrient-rich wastewater, which often contains metals such as Cu and Zn, used feed additives for pigs. These must be removed from the wastewater before discharge but their retention in biomass can limit subsequent utilization. Photobioreactors are a very promising alternative swine treatment, consortium microalgae bacteria growing symbiotically these reactors allows high nutrient metal removal efficiency at moderate costs. This work studies...
Abstract Background and Aims Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics management PSC IBD patients, factors malignancies. Methods patients were identified from Spanish ENEIDA registry GETECCU. Additional data collected using AEG-REDCap electronic capture...
non-alcoholic fatty liver disease (NAFLD) is the most common chronic disorder in western world. Although NAFLD prevalence higher patients with a BMI > 25 kg /m2, it unclear if there are differences between overweight and obese patients. The associated biochemical, dietary genetic parameters were compared NAFLD.patients biopsy-proven (n = 203) enrolled cross-sectional study. MEDAS questionnaire was used to assess adherence Mediterranean diet. Biochemical, anthropometrical I148M variant...
Summary Background Methotrexate can be used to maintain remission in Crohn's disease patients who are intolerant thiopurines. Data on its use as monotherapy other scenarios limited. Aim To assess the effectiveness of methotrexate after previous failure anti‐tumour necrosis factor (anti‐TNFα) drugs. Methods A retrospective, observational multicentre study data from Spanish ENEIDA registry. Participants were with active and anti‐TNFα started monotherapy. Short‐term was assessed at 12‐16 weeks...
Introduccion: la esplenomegalia y/o las lesiones ocupantes de espacio (LOE) esplenicas, han tenido limitaciones en su estudio histopatologico por el riesgo que suponen punciones esplenicas. Las biopsias percutaneas con aguja fina, son dificiles especial interposicion gases, ascitis, obesidad o antecedentes cirugia abdominal. En cambio, ultrasonido endoscopico (USE) aprovecha proximidad pared gastrica bazo, para puncionar visualizacion y sus movimientos tiempo real. Objetivo: describir...
Ustekinumab is a monoclonal antibody targeting interleukins 12 and 23. Its effectiveness in clinical practice has not yet been demonstrated. The aim of this study was to assess the real-world, short-term ustekinumab medically refractory Crohn’s disease (CD) (CROHNUSK study). Multi-centre CD patients receiving after June 2017 (when it approved Spain) at recommend dose (a single iv infusion 6 mg/kg followed by sc injection 90 mg Week 8). Harvey‐Bradshaw Index (HBI) used evaluate remission (HBI...
Primary sclerosing colangitis (PSC) is a chronic cholestasic liver disease usually associated with inflammatory bowel (IBD). An increased risk of malignancies (colorectal cancer and cholangiocarcinoma) has been reported in IBD patients PSC. Our aim was to determine the clinical characteristics, management PSC Spanish patients. were identified from prospectively maintained ENEIDA registry GETECCU. Additional data collected using REDCap electronic capture tool hosted at AEG (Asociación...
Abstract Background Treatment with thiopurines in patients Inflammatory Bowel Disease (IBD) may be associated different adverse effects, including acute pancreatitis. Our aims were to evaluate the clinical presentation, severity and management of pancreatitis related IBD. Methods IBD secondary treatment for identified from prospectively maintained ENEIDA registry Spanish Working Group on Crohn’s Ulcerative Colitis (GETECCU). We included those who met Atlanta diagnostic criteria had an...
Abstract Background Treatment with thiopurines may be associated different adverse effects, including acute pancreatitis. Risk factors for developing pancreatitis due to in patients Inflammatory Bowel Disease (IBD) are not clearly identified, underlying genetic predisposition being a possible cause. Our aim was evaluate predictive pharmacogenetic risk of IBD treated thiopurines. Methods were identified from the prospectively maintained ENEIDA registry Spanish Working Group on Crohn’s and...
Objectives Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of histological phenotypes including steatosis, steatohepatitis (NASH) and fibrosis. While biopsy is the reference for diagnosis, it invasive associated with procedural risks sampling variability. There urgent need noninvasive diagnostic procedure. Recently, we have described serum-based lipidomic signature NAFLD able to fulfill these unmet needs by: differentiating from healthy cohort; discriminating between steatosis...