A5009163999- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Diabetes and associated disorders
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Cardiac, Anesthesia and Surgical Outcomes
- Blood groups and transfusion
- Metabolomics and Mass Spectrometry Studies
- Advanced Glycation End Products research
- Free Radicals and Antioxidants
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and Mental Health
- Pancreatitis Pathology and Treatment
- Respiratory Support and Mechanisms
- Diet, Metabolism, and Disease
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
Hospital Clínico Universitario de Valladolid
2020-2025
Instituto de Salud Carlos III
2022-2025
Centre for Biomedical Network Research on Rare Diseases
2021-2025
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2019-2024
Biomedical Research Institute of Lleida
2012-2024
Centro de Investigación Biomédica en Red
2022-2024
Universidad de Valladolid
2021-2022
Hospital Universitari Arnau de Vilanova
2016
Universitat de Lleida
2008-2015
Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role response infections. A defective redox balance has been related viral developing massive induction of cell death provoked by oxidative stress. The aim this study is perform complete profile evaluation regarding antioxidant enzymes, total capacity and damage order characterize diagnosis severity disease.
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis oxidation/secretion in the a major feature NAFLD. Given lack non-invasive reliable methods for diagnosis non-alcoholic steatohepatitis (NASH), it important find serum markers are capable discriminating or defining patients with this stage NASH. Blood samples were obtained from 152...
Abstract Metabolomic and lipidomic analyses have been used for the profiling of neurodegenerative processes, both in targeted untargeted approaches. In this work we applied these techniques to study CSF samples multiple sclerosis ( MS ) patients n = 9), compared with non‐ individuals 9) using mass‐spectrometry. We western‐blot analyzed cell culture confirm pathogenic pathways suggested by mass‐spectrometric measurements. The results approach metabolomics lipidomics suggest existence several...
Abstract Background The presence of headache during the acute phase COVID-19 could be associated with innate response and cytokine release. We aim to compare interleukin profile in hospitalized patients at moment admission without course disease. Methods An observational analytic study a case control design was performed. Hospitalized from tertiary hospital confirmed disease were included. Patients classified into or group depending on whether they presented not better accounted for by...
Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify cytokines responsible for lung damage mortality. prospectively recruited 108 COVID-19 patients between March April 2020 divided them into four groups according severity respiratory symptoms. Twenty-eight healthy volunteers were used normalization results. Multiple showed statistically significant differences mild critical patients. High HGF levels associated with...
Abstract Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The involvement of lipids as one main components myelin sheaths in MS other demyelinating diseases postulated. However, still matter debate whether specific alteration patterns exist over disease course. Here, using lipidomic approach, we that, at time diagnosis,...
Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), which immune system is known to play a key role. However, date, OS peripheral lymphocytes and its contribution disease remain unknown. The aim present study was explore influence MS patients. To end, cross-sectional, observational pilot conducted [n = 58: 34 24 healthy subjects (control group)]. We have measured superoxide production protein mitochondrial complex levels blood...
Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity non-septic shock. Extracellular vesicle-derived miRNAs may serve as biomarkers distinguish from shock, providing a more accurate diagnostic tool for postsurgical patients. This study aims identify extracellular miRNA signatures that differentiate in patients, potentially improving accuracy and decision-making. A multicentre, prospective was conducted on profiles Two cohorts were recruited...
Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution COVID-19. an observational prospective study. primary endpoint was analyze between lipid peroxidation, lipid, inflammatory profiles COVID-19 patients. A multivariate regression analysis employed....
Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in patients to identify novel biomarkers. A discovery–validation study two independent prospective cohorts was performed. The discovery cohort included 136 and non-COVID-19 recruited consecutively from 24 March 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system...
Scope The intake of food rich in polyphenols is related to a lower incidence almost all chronic degenerative diseases. However, relatively little known about the molecular mechanisms involved its antioxidant properties. aim this study was determine whether mechanism action could be modulation energy uptake and metabolism, further induced mitochondrial changes. Methods results For purpose, male C 57 B L6 mice were fed during 3 months with tea‐based beverage polyphenols. Insulin sensitivity,...
Pneumonia is the main cause of hospital admission in COVID-19 patients. We aimed to perform an extensive characterization clinical, laboratory, and cytokine profiles order identify poor outcomes Methods: A prospective consecutive study involving 108 patients was conducted between March April 2020 at Hospital Clínico Universitario de Valladolid (Spain). Plasma samples from each patient were collected after emergency room admission. Forty-five serum cytokines measured duplicate, clinical data...
Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group also with the prevalence and severity this disease. However, relationship between profile remains unclear in COVID-19 patients. In sense, we prospectively recruited 108 patients March April 2020 divided according ABO group. For analysis 45 cytokines, plasma samples were collected time admission hospital ward or intensive care unit at sixth day...
Nowadays, mortality rates in intensive care units are the highest of all hospital units. However, there is not a reliable prognostic system to predict likelihood death patients with postsurgical shock. Thus, aim present work obtain gene expression signature distinguish low and high risk shock patients. In this sense, mRNA levels were evaluated by microarray on discovery cohort select most differentially expressed genes between surviving non-surviving groups 30 days after operation. Selected...
A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where the absence of H(2)O(2), could serve as oxidizing substrates for peroxidases. However, relevance those findings not been evaluated. The main objective this study was to determine whether products produced peroxidase gallic acid concentration 1 microM may promote cell death or survival human microvascular endothelial line (HMEC-1). Our...
<title>Abstract</title> <bold>Background</bold>: Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19), attributed to a cytokine storm. The objective our study characterize this profile identify cytokines responsible for lung damage mortality.<bold>Methods: </bold>Plasma samples 108 prospectively recruited COVID-19 patients were collected between March and<sup> </sup>April 2020. Patients divided into four groups according severity...