A5042864387- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- interferon and immune responses
- Celiac Disease Research and Management
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Microscopic Colitis
- Long-Term Effects of COVID-19
- Genomics and Rare Diseases
- Phagocytosis and Immune Regulation
- Diabetes and associated disorders
- Reproductive System and Pregnancy
- Pancreatitis Pathology and Treatment
- Viral Infections and Immunology Research
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- COVID-19 diagnosis using AI
- Abdominal vascular conditions and treatments
- Digestive system and related health
- PARP inhibition in cancer therapy
- Helicobacter pylori-related gastroenterology studies
Instituto de Biomedicina y Genética Molecular de Valladolid
2020-2025
Universidad de Valladolid
2020-2025
Consejo Superior de Investigaciones Científicas
2022
Background: Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for SARS-CoV-2, particularly in respiratory system, GAS6/AXL axis targeted current clinical trials against COVID-19. However, GAS6 TAMs have not been evaluated COVID-19 patients at emergency admission. Methods: Plasma GAS6, were analyzed 132 consecutively admitted to ward during first peak of Results: levels higher...
Abstract Background Human intestinal conventional dendritic cells (cDC) maintain the mechanisms of immune tolerance in health. However, their specific contribution to development inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn´s (CD) remains elusive Methods cDC were identified by flow cytometry human mucosal, divided into CD103- cDC2, CD103+ cDC2 cDC1. Their phenotype was determined health IBD, together with stimulatory capacity over naïve T-cells. Results cDC1...
Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in patients to identify novel biomarkers. A discovery–validation study two independent prospective cohorts was performed. The discovery cohort included 136 and non-COVID-19 recruited consecutively from 24 March 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system...
Introduction Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people. Methods Hence, we performed prospective experimental cohort study to characterise effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults oncohaematologic patients), compared healthy counterparts, based deep characterisation circulating immune cell subsets. Results discussion...
Intraepithelial lymphocytes are the first line of defence human intestinal immune system. Besides, their composition is altered on patients with coeliac disease (CD), so they considered as biomarkers utility diagnose and/or monitoring. Our aim to address variability through gastrointestinal tract in health and characterized them further depth duodenum.
The immune cellular landscape from the gastric mucosa remains largely unknown despite its relevance in several inflammatory conditions. Human biopsies were obtained antrum, body and incisura 10 individuals to obtain lamina propria mononuclear cells that further characterized by spectral cytometry. Phenotypic hierarchical analyses identified a total of 52 different cell subsets within human revealing T-cells (> 60%) NK 20%) main populations. Within T-cells, CD4+ CD8+ equally represented with...
Although the COVID-19 disease has developed into a worldwide pandemic, its pathophysiology remains to be fully understood. Insulin-degrading enzyme (IDE), zinc-metalloprotease with high affinity for insulin, been found in interactomes of multiple SARS-CoV-2 proteins. However, relevance IDE innate and adaptative immune responses elicited by circulating peripheral blood mononuclear cells is unknown. Here, we show that highly expressed on surface monocytes, T-cells (both CD4+ CD4-), and, lower...
ABSTRACT COVID-19 affects the population unequally with a higher impact on aged and immunosuppressed people. Hence, we assessed effect of SARS-CoV-2 vaccination in immune compromised patients (older adults oncohematologic patients), compared healthy counterparts. While acquired humoral cellular memory did not predict subsequent infection 18 months after full immunization, spectral computational cytometry revealed several subsets within CD8 + T-cells, B-cells, NK cells, monocytes CD45RA CCR7...
Abstract Background Crohn’s disease (CD) is a chronic inflammation of the human gastrointestinal tract. Intestinal conventional dendritic cells (cDC) maintain balance between immunity against pathogens and tolerance towards nutrients commensals. However, there not much information about DC composition, phenotype function in gut CD. Methods Human intestinal resections were obtained from patients with ileocolonic CD proximal colonic cancer. Both inflamed non-inflamed tissue was ileum colon...