A5061934732- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Immune responses and vaccinations
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Abdominal vascular conditions and treatments
- Diabetes and associated disorders
- COVID-19 diagnosis using AI
- Genomics and Rare Diseases
- Mycobacterium research and diagnosis
- Microscopic Colitis
- Genetics and Neurodevelopmental Disorders
- PARP inhibition in cancer therapy
- Enterobacteriaceae and Cronobacter Research
- Phagocytosis and Immune Regulation
Instituto de Biomedicina y Genética Molecular de Valladolid
2021-2024
Universidad de Valladolid
2019-2024
Background: Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for SARS-CoV-2, particularly in respiratory system, GAS6/AXL axis targeted current clinical trials against COVID-19. However, GAS6 TAMs have not been evaluated COVID-19 patients at emergency admission. Methods: Plasma GAS6, were analyzed 132 consecutively admitted to ward during first peak of Results: levels higher...
Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in patients to identify novel biomarkers. A discovery–validation study two independent prospective cohorts was performed. The discovery cohort included 136 and non-COVID-19 recruited consecutively from 24 March 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system...
Introduction Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people. Methods Hence, we performed prospective experimental cohort study to characterise effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults oncohaematologic patients), compared healthy counterparts, based deep characterisation circulating immune cell subsets. Results discussion...
Cronobacter sakazakii is an opportunistic pathogen that associated with outbreaks of neonatal necrotizing enterocolitis, septicaemia, and meningitis. Reconstituted powdered infant formulae the most common vehicle infection. The aim present study to gain insight into physiological states C. cells using flow cytometry detect compromised cells, which are viable but non-culturable plate-based methods, evaluate impact milk heat treatments on those populations. Dead-cell suspensions as well...
The immune cellular landscape from the gastric mucosa remains largely unknown despite its relevance in several inflammatory conditions. Human biopsies were obtained antrum, body and incisura 10 individuals to obtain lamina propria mononuclear cells that further characterized by spectral cytometry. Phenotypic hierarchical analyses identified a total of 52 different cell subsets within human revealing T-cells (> 60%) NK 20%) main populations. Within T-cells, CD4+ CD8+ equally represented with...
ABSTRACT COVID-19 affects the population unequally with a higher impact on aged and immunosuppressed people. Hence, we assessed effect of SARS-CoV-2 vaccination in immune compromised patients (older adults oncohematologic patients), compared healthy counterparts. While acquired humoral cellular memory did not predict subsequent infection 18 months after full immunization, spectral computational cytometry revealed several subsets within CD8 + T-cells, B-cells, NK cells, monocytes CD45RA CCR7...