A5015974810- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Vitamin D Research Studies
- Telomeres, Telomerase, and Senescence
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects and Toxicity Studies
- interferon and immune responses
- Renal Transplantation Outcomes and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Adrenal Hormones and Disorders
Instituto de Salud Carlos III
2016-2025
Centro de Investigación Biomédica en Red
2021-2025
Centro Nacional de Microbiologia
2015-2024
Escuela Nacional de Sanidad
2024
Universidad Alfonso X el Sabio
2021
Hospital Universitario Ramón y Cajal
2009-2015
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2009-2012
Instituto Nacional de Toxicología y Ciencias Forenses
1996
MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early disease onset and before the detection of pathogen. Thus, we aimed to analyze plasma miRNA profile at COVID-19 identify miRNAs as prognostic biomarkers severity survival.Plasma miRNome 96 patients that developed asymptomatic/mild, moderate severe was sequenced together with group healthy controls. Plasma immune-related were also assessed. showed 200 significant...
Background metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize cytokine profile at onset relationship with disease severity identify profiles predicting progression. Material Methods performed retrospective cross-sectional study in 123 patients which were stratified asymptomatic/mild,...
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved orchestrating immune response against cytomegalovirus (CMV) and 12-month incidence of CMV infection 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. occurred 140 patients (44.4%), including 13 episodes disease. After adjusting for various clinical covariates, harboring T-allele genotypes...
Previous results from a genome scan in an F2 Iberian × Meishan pig intercross showed several chromosome regions associated with litter size traits this species. In order to identify candidate genes underlying these quantitative trait loci (QTL), we performed ovary gene expression analysis during the sow's pregnancy. sows were ranked by their estimated breeding values for prolificacy: six highest value (EBV) (i.e., high prolificacy) and lowest EBV (low selected. Samples hybridized using...
In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared HIV-monoinfected thereby likely contributing increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was evaluate influence of coinfection in viral size resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study 97 cART-treated including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32...
Hepatitis C virus (HCV) and human immunodeficiency (HIV) hijack the host exosomal machinery as an additional mechanism of infection evasion immune system, modifying small RNA (smRNA) cargo during infection. We characterized surface epitopes extracellular vesicles (EVs) from plasma HIV/HCV-coinfected patients their smRNA profile, by comparing different isolation procedures. Six EVs procedures were compared: ultracentrifugation, five polyethylene glycol-based methods (commercial, combined with...
Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity non-septic shock. Extracellular vesicle-derived miRNAs may serve as biomarkers distinguish from shock, providing a more accurate diagnostic tool for postsurgical patients. This study aims identify extracellular miRNA signatures that differentiate in patients, potentially improving accuracy and decision-making. A multicentre, prospective was conducted on profiles Two cohorts were recruited...
Extracellular vesicles (EVs) are an increasingly promising tool for liquid biopsy in liver diseases. Hepatitis C Virus (HCV) infection, alone or together with Human Immunodeficiency (HIV) infection significantly impacts on the microRNA (miRNA) EVs content resembling chronic hepatitis (CHC) progression. The objective of study was to delve into intricate EVs-miRNA profiles CHC patients different fibrosis stages, aiming pinpoint non-invasive markers capable distinguishing significant fibrosis....
The cytokine profile plays an important role in treatment outcome of hepatitis C virus (HCV) infection, and probably modulates the immune response against HCV. aim this study was to evaluate which cytokines affect interferon-α (IFN-α) ribavirin therapy how these change 72 weeks after starting anti-HCV HIV/HCV-coinfected patients. We carried out a retrospective follow-up 65 patients on therapy. A sustained virological (SVR) defined as undetectable HCV viral load up 24 end treatment. Cytokines...
Background Reproductive traits play a key role in pig production order to reduce costs and increase economic returns. Among others, gene expression analyses represent useful approach study genetic mechanisms underlying reproductive pigs. The application of reverse-transcription quantitative PCR requires the selection appropriate reference genes, whose levels should not be affected by experimental conditions, especially when comparing across different physiological stages. Results stability...
TRIM5 and TRIM22 are restriction factors involved in innate immune response exhibit anti-viral activity. Single nucleotide polymorphisms (SNPs) at genes have shown to influence several viral infections such as human immunodeficiency virus (HIV), hepatitis B, well measles rubella vaccination. The aim of this study is analyze whether associated with liver fibrosis inflammation-related biomarkers pegylated-interferon-alpha plus ribavirin (pegIFNα/RBV) therapy HIV/hepatitis C (HCV) coinfected...
Observational studies in healthy people suggest an inverse relationship between 25-hydroxy-vitamin D (25(OH)D levels) and cardiovascular diseases malignancies. We performed observational prospective study renal transplant recipients to investigate the effects of vitamin deficiency on malignancy risks. From 389 recipients, 331 with a functioning graft at 12 months were included study. Mineral metabolism parameters measured 1, 3, 4 months. Information regarding events malignancies collected...
IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was analyse whether IL-1B rs16944 polymorphism associated with the onset septic death after major surgery.We performed case-control study on 467 patients who underwent cardiac or abdominal surgery. Of them, 205 developed (cases, SS group) 262 SIRS (controls, group). The outcome variables were development within 90 days diagnosis shock. genotyped by Sequenom's MassARRAY...
Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly improves the liver and immune system. We aimed to assess impact of this HCV clearance on system-related markers in plasma gene expression profile human immunodeficiency (HIV)/HCV-coinfected patients with advanced cirrhosis. performed a prospective study 33 HIV/HCV-coinfected at baseline 36 weeks sustained virological response. Gene was evaluated by RNA-seq analysis peripheral blood mononuclear cells...