Current American-European Consensus Conference definitions for acute lung injury (ALI) and respiratory distress syndrome (ARDS) are inadequate inclusion into clinical trials due to the lack of standardization measuring oxygenation defect.We questioned whether an early assessment on specific ventilator settings would identify patients with established ARDS (persisting over 24 h).At time meeting criteria (Day 0) hours later 1), arterial blood gases were obtained standard settings, Vt 7 ml/kg...

Abstract Glycals (1,2‐unsaturated, cyclic carbohydrate derivatives) readily undergo (catalyzed) substitution reactions at C‐1 accompanied by allylic rearrangement. This reaction, currently named Ferrier rearrangement, or the I has established itself as a useful synthetic tool for transformations. By means of this glycals can be converted into highly 2,3‐unsaturated glycosides. review summarizes recent developments in use promoters rearrangement O‐, N‐, C‐ and S‐nucleophiles with glycals.

To test the hypothesis that prone position ventilation, nitric oxide, and almitrine bismesylate, each acting by a different mechanism to improve arterial oxygenation, could exert additive beneficial effects when used in combination patients with severe acute respiratory distress syndrome (ARDS).Prospective, nonrandomized, interventional study.Medical surgical intensive care units at university tertiary center.Twelve ARDS hypoxemia, defined as PaO2/FIO2 of < or = 150 FIO2 > 0.6, pulmonary...

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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFerrier Rearrangement under Nonacidic Conditions Based on Iodonium-Induced Rearrangements of Allylic n-Pentenyl Esters, Glycosides, and Phenyl ThioglycosidesJ. Cristobal Lopez, Ana M. Gomez, Serafin Valverde, Bert Fraser-ReidCite this: J. Org. Chem. 1995, 60, 12, 3851–3858Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June...

Two desmotropes, 3-phenyl-1H-pyrazole (1a) and 5-phenyl-1H-pyrazole (1b) have been isolated the conditions for their interconversion established. The X-ray structure of 1b has determined (a=10.862(1), b=5.7620(5), c=12.927(2) Å, β=111.435(2)°, space group P21/c), both tautomers 1a were characterized by NMR in solid state (13C- 15N-CPMAS). In case 3-phenyl-1H-indazole (2a), two concomitant polymorphs analyzed crystallography, spectral properties determined. low-melting-point polymorph, at...

Abstract Three modes of selectivity — enantio, stereo, and regio are critically important for efficient organic synthesis. In the sub‐domain oligosaccharide synthesis, first is (usually!) irrelevant in view chiralities reacting partners. The challenge posed by other two compounded reality that “protecting groups” major, if not only, instruments which control can be exercised. role O2 protecting groups play stereocontrol coupling reactions was formulated 60 years ago. this microreview,...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSerial Radical Reactions of Glycals: Ready Routes to Highly Functionalized C-Glycosyl DerivativesJ. Cristobal Lopez, Ana M. Gomez, and Bert Fraser-ReidCite this: J. Org. Chem. 1995, 60, 12, 3871–3878Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00117a044https://doi.org/10.1021/jo00117a044research-articleACS PublicationsRequest reuse...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary Metabolites from Satureja Species. New Triterpenoid acinosJavier Escudero, J. Cristóbal López, Rosa Maria Rabanal, and Serafiń ValverdeCite this: Nat. Prod. 1985, 48, 1, 128–131Publication Date (Print):January 1985Publication History Published online1 July 2004Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/np50037a025https://doi.org/10.1021/np50037a025research-articleACS PublicationsRequest reuse permissionsArticle...

The cytokine profile plays an important role in treatment outcome of hepatitis C virus (HCV) infection, and probably modulates the immune response against HCV. aim this study was to evaluate which cytokines affect interferon-α (IFN-α) ribavirin therapy how these change 72 weeks after starting anti-HCV HIV/HCV-coinfected patients. We carried out a retrospective follow-up 65 patients on therapy. A sustained virological (SVR) defined as undetectable HCV viral load up 24 end treatment. Cytokines...

Abstract Two complementary one‐pot, three component synthetic strategies based on copper(I)‐catalyzed azide–alkyne cycloadditions (CuAAC) have been developed, which allow the efficient assembly of glycosyl‐derived alkynes or azides with highly fluorescent boron–dipyrromethene (BODIPY) cores containing azido alkyne moieties, respectively. The resulting carbohydrate–BODIPY derivatives display excellent photophysical and laser properties that relate to spacer (amino group aromatic ring)...

Hitherto unreported 2,6-dipropargyl-1,3,5,7-tetramethyl BODIPYs can be efficiently prepared by a Nicholas reaction/decomplexation protocol from 1,3,5,7-tetramethyl BODIPYs. The title compounds, which improve the BODIPY photostability retaining their inherent photophysical and photochemical properties, engaged in efficient copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) "click-type" reactions with azido derivatives to provide all-BODIPY-triads or conjugated

This paper is dedicated to the vital role of Acceleration Services in fostering digital transformation Higher Education Institutions (HEIs). Institutional pivotal for promoting innovation, elevating research and teaching quality, interdisciplinary collaboration, enhancing societal impact HEIs. Through a focused case study, we shed light on implementation acceleration services within an HEI, specifically A University Partnership European Universities (aUPaEU) project. comprehensive analysis...

n-Pentenyl esters, which are readily obtained by mild esterification of the anomeric hydroxy group sugars, can be efficiently used in glycosidation reactions, and they appear to less prone armed–disarmed phenomena than their n-pentenyl glycoside counterparts.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSerial radical reactions of enol ethers: ready routes to highly functionalized C-glycosyl derivativesJ. Cristobal Lopez and Bert Fraser-ReidCite this: J. Am. Chem. Soc. 1989, 111, 9, 3450–3452Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ja00191a064https://doi.org/10.1021/ja00191a064research-articleACS PublicationsRequest reuse permissionsArticle...

Carbasugars (a term coined for the carbocyclic analogues of carbohydrates) play a prominent role within broad field carbohydrate mimetics. Natural carbasugars, either as single molecules or subunits more complex molecules, have shown to display interesting biological activities. On other hand, synthetic carbasugars also similar Normally, construction framework is regarded key step in synthesis carbasugars. In this context, use ring closing metathesis (RCM) has proven be great value recent...

Abstract Metathetical processes play a prominent role in the development of useful transformations because their mildness, tolerance functional groups, and synthetic potential. On other hand, carbohydrates have gained well‐deserved relevance study biological processes. This review summarizes decade efforts application cross metathesis (CM) reactions to preparation some relevant glycoconjugates.

O-Ethylation of phthalides with Meerwein's reagent followed by reaction the ensuing salts pyrrole, results in formation 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors ortho-substituted 8-aryl BODIPY derivatives borontrifluoride etherate, an overall process that can be carried out a one-pot operation.