A5086595504- Phytochemicals and Antioxidant Activities
- Amyotrophic Lateral Sclerosis Research
- Genomics, phytochemicals, and oxidative stress
- Parkinson's Disease Mechanisms and Treatments
- Bioactive natural compounds
- Neurogenetic and Muscular Disorders Research
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Protein Kinase Regulation and GTPase Signaling
- Nutrition and Health in Aging
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Glutathione Transferases and Polymorphisms
- Mitochondrial Function and Pathology
- Food composition and properties
- Natural Antidiabetic Agents Studies
- Endoplasmic Reticulum Stress and Disease
- Natural product bioactivities and synthesis
- Phytoestrogen effects and research
- Dietary Effects on Health
- Nerve injury and regeneration
- Fungal Biology and Applications
- Hibiscus Plant Research Studies
Universitat de Lleida
2013-2024
Biomedical Research Institute of Lleida
2011-2021
Institute for Research in Biomedicine
2016
Consejo Superior de Investigaciones Científicas
2005-2012
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
2009-2010
Cambridge University Press
2009
New York University Press
2009
Abstract Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was characterize the faecal signature and both short chain fatty acids (SCFAs) bile (BA) profile hypercholesterolemic subjects. Microbiota composition, SCFAs, BA blood from male volunteers with hypercholesterolemia (HC) normocholesterolemia (NC) were determined by 16S rDNA sequencing, HPLC, GC NMR, respectively. HC subjects characterized having lower relative abundance Anaeroplasma (0.002% vs...
Hydroxytyrosol (HTy) is a natural polyphenol abundant in olive oil, which possesses multiple biological actions. Particularly, HTy has cytoprotective activity against oxidative-stress-induced cell damage, but the underlying mechanisms of action remain unclear. Here, we have investigated molecular mechanism involved protection exerted by on tert-butyl hydroperoxide-induced damage human HepG2 liver cells. Treatment cells with increased expression and glutathione-related enzymes such as...
Dietary polyphenols have been associated with reduced risk of chronic diseases, but the precise molecular mechanisms protection remain unclear. This work was aimed at studying effect (−)-epicatechin (EC) and chlorogenic acid (CGA) on regulation apoptotic survival/proliferation pathways in a human hepatoma cell line (HepG2). EC or CGA treatment for 18 h had slight viability decreased reactive oxygen species formation, alone promoted proliferation, whereas increased glutathione levels. Phenols...
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. objective the present study was investigate time-dependent regulation by on activity main transcription factors (NF-κB, activator protein-1 (AP-1) and nuclear factor erythroid 2p45-related (Nrf2)) related antioxidant defence survival proliferation pathways in HepG2 cells. Treatment cells with 10 μ m -epicatechin induced NF-κB pathway manner characterised increased levels IκB kinase (IKK)...
Quercetin, a dietary flavonoid, has been shown to possess anticarcinogenic properties, but the precise molecular mechanisms of action are not thoroughly elucidated. The aim this study was investigate regulatory effect quercetin (50 microM) on two main transcription factors (NF-kappa B and AP-1) related survival/proliferation pathways in human hepatoma cell line (HepG2) over time. Quercetin induced significant time-dependent inactivation NF-kappa pathway consistent with downregulation binding...
The dietary flavonoid quercetin is an antioxidant that possesses antiinflammatory and anticarcinogenic properties may modulate signaling pathways. Inflammation considered to play a pivotal role in carcinogenesis by triggering activation of transcription factors such as nuclear factor kappa B (NF-κB), functionally dependent on cellular redox status. This study aims investigate the effect its NF-κB pathway, cyclooxygenase-2 (COX-2) mitogen-activated protein kinases modulation human hepatoma...
TARDBP (TAR DNA binding protein) is one of the components neuronal aggregates in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We have developed a simple quantitative method to evaluate splicing function that was applied spinal cord, brainstem, motor cortex, occipital cortex ALS (n = 8) cases compared age- gender-matched control 17). Then, we quantified abundance TARDBP-spliced cryptic exon present ATG4B (autophagy related 4B cysteine peptidase) mRNA....
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction its pathogenesis, though differences between genders have not been evaluated. For this reason, we analysed features metabolism, as well chain complex enzyme activities protein expression, lipid profile, markers, Cu,Zn superoxide dismutase G93A mutation (hSOD1-G93A)- transgenic mice...
A new soluble cocoa fiber product (SCFP), obtained after enzymatic treatment of husks, was characterized and its potential health effects studied in an animal model dietary-induced hypercholesterolemia. The SCFP rich dietary (DF) antioxidant polyphenols. Consumption a cholesterol-rich diet containing the as source DF resulted lower food intake body weight gain comparison with control groups consuming cholesterol-free or diets cellulose DF. caused remarkable However, diminished negative...
Quercetin, a dietary flavonoid, has been shown to possess anticarcinogenic properties, but the precise molecular mechanisms of action are not thoroughly elucidated. This study was aimed at investigating time-course regulation effect quercetin on survival/proliferation pathways in human hepatoma cell line (HepG2). Quercetin induced significant time-dependent inactivation major survival signaling proteins, i. e., phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (AKT), extracellular...
Soybean is recognized as rich source of bioactive compounds for the improvement glucose homeostasis. However, post-prandial mechanisms action have not been extensively described. The aim this study to determine changes in homeostasis and related factors after acute intake a soy beverage. Twenty-nine subjects (15 women 14 men, with an average age 19.5 ± 1.2) ingested 500 mL water, (20.5 g/500 mL) beverage (20 g carbohydrate) three separate sessions. Capillary blood was monitored every 15 min...
This study aimed to determine how the microbiota profile might be predisposed a better response in blood lipid profiles due dietary fibre supplementation. A three-arm intervention that included three different types (mainly insoluble, soluble, and antioxidant fibre) supplemented (19.2 g/day) during 2 months individuals with hypercholesterolemia was developed. Changes faecal after supplementation were determined. In all volunteers, regardless of type, an increase abundance Bifidobacterium...