A5063172840- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pharmacovigilance and Adverse Drug Reactions
- Global Cancer Incidence and Screening
- Asthma and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Computational Drug Discovery Methods
- Occupational exposure and asthma
- Celiac Disease Research and Management
- Microscopic Colitis
- Pulmonary Hypertension Research and Treatments
- Respiratory and Cough-Related Research
- Lung Cancer Research Studies
- Pneumonia and Respiratory Infections
- Statistical Methods in Clinical Trials
- Chronic Disease Management Strategies
- Biomedical Text Mining and Ontologies
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Allergic Rhinitis and Sensitization
University of Nottingham
2016-2025
Brown University
2025
Nottingham City Hospital
2011-2024
National Institute for Health Research
2017-2024
Nottingham Biomedical Research Centre
2011-2024
Observational & Pragmatic Research Institute
2024
Lifespan
2021-2023
Nottingham University Hospitals NHS Trust
2013-2023
Regional West Medical Center
2023
University of Michigan
2023
There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis acute infection and vaccination increase short-term risk of vascular events.
Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it recently become apparent that cigarette smoking may a factor for cryptogenic as well cancer, and so confound the association between these conditions. We have therefore estimated independent increase in cancer incidence patients compared general population population-based cohort study involving 890 subjects 5,884 control drawn from United Kingdom General Practice Research...
Idiopathic pulmonary fibrosis (IPF) and sarcoidosis are common diagnoses in patients attending chest clinics, but little is known about the epidemiology of these diseases. We used data from a general practice database to provide information on current incidence IPF UK.Data were extracted for all with diagnosis or between 1991 2003. The whole population was calculate disease stratified by age, sex, region, time period. Poisson regression compare populations Cox survival populations.920 cases...
<h3>Background</h3> Previous studies have shown that the incidence of idiopathic pulmonary fibrosis (IPF) is rising in UK and USA. Death registrations primary care data were used to determine current trends IPF UK. Because routine clinical sets used, term syndrome (IPF-CS) describe individuals this study. <h3>Methods</h3> Age- stratum-specific death registration rates between 1968 2008 calculated these applied population generate annual standardised expected number deaths. Annual mortality...
BackgroundUnderstanding the genetic basis of airflow obstruction and smoking behaviour is key to determining pathophysiology chronic obstructive pulmonary disease (COPD). We used UK Biobank data study causes lung health.MethodsWe sampled individuals European ancestry from Biobank, middle extremes forced expiratory volume in 1 s (FEV1) distribution among heavy smokers (mean 35 pack-years) never smokers. developed a custom array for provide optimum genome-wide coverage common low-frequency...
Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial disease but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable broader populations.Objectives: To assess in-hospital after surgical for national secondary care dataset the United States.Methods: Data were obtained 2000–2011 Nationwide Inpatient Sample. Cases identified using International Classification of Diseases codes biopsies....
Comorbidities associated with systemic inflammation including cardiovascular disease (CVD), stroke and diabetes mellitus (DM) are common among individuals chronic obstructive pulmonary (COPD). A study was undertaken to quantify the burden of comorbidity determine risk first acute arteriovascular events COPD.The computerised primary care records 1,204,100 members general population aged ≥ 35 years on 25 February 2005 were searched for recordings each disease. Data analysed using multivariate...
<h3>Abstract</h3> <b>Objective</b> To quantify the risks of malignancy and mortality in people with coeliac disease compared general population. <b>Design</b> Population based cohort study. <b>Setting</b> General practice research database. <b>Participants</b> 4732 23 620 matched controls. <b>Main outcome measures</b> Hazard ratios for mortality. <b>Results</b> Of disease, 134 (2.8%) had at least one 237 (5.0%) died. The overall hazard were: any 1.29 (95% confidence interval 1.06 to 1.55),...
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified significant genetic risk associated the development of IPF; however, mechanisms by which factors promote IPF remain unclear. We aimed to identify variants susceptibility provide mechanistic insight using gene protein expression analyses.MethodsWe used two-stage approach: genome-wide association study in patients European...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
We have undertaken a large case–control study using the UK General Practice Research Database to quantify relative contributions of common risk factors for carpal tunnel syndrome (CTS) in community. Cases were patients with diagnosis CTS and, each, four controls individually matched by age, sex and general practice. Our dataset included 3,391 cases, which 2,444 (72%) women, mean age at 46 (range 16–96) years. Multivariate analysis showed that associated previous wrist fracture (OR = 2.29),...
The etiology of allergic disease is not understood, but a decreased exposure to infection may play an important role. There are few published data on the impact change in microbial during pregnancy child's risk developing disease. Using birth cohort 24,690 children, derived from West Midlands General Practice Research Database, we investigated number perinatal exposures incidence asthma, eczema, and hay fever. Our findings suggest that antibiotics utero associated with increased asthma...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The effect of statins on cardiovascular outcomes is well established. Effects numerous other health have been claimed, but results inconsistent. Previous observational studies may affected by selection bias and confounding. STUDY ADDS This study was larger more statistically powerful than the combined total data from all randomized trials undertaken to date. validity supported findings for vascular being comparable those observed in large controlled...
Rationale: Previous studies have suggested that people with idiopathic pulmonary fibrosis (IPF) may be at increased risk of vascular disease.Objectives: To quantify the cardiovascular disease before and after a diagnosis IPF.Methods: We used computerized primary care data from Health Improvement Network to relative having event (acute coronary syndrome, angina, atrial fibrillation, deep-vein thrombosis, cerebrovascular accident) either or IPF in comparison age, sex, community-matched general...
Abstract We determined the trends in incidence of skin basal cell carcinoma (BCC) using a primary care population‐based cohort study UK. 11,113 adults with BCC diagnosis were identified from total 7.22 million person‐years data between 1996 and 2003 Health Improvement Network database. From random subsample cases database, 93% confirmed by hospital letter and/or pathology report. The was 153.9 per 100,000 (95% CI 151.1, 156.8) slightly higher men as compared to women (Incidence Rate Ratio...
There is accumulating evidence that the use of inhaled corticosteroids associated with a dose-related reduction in bone mineral density. Whether this translates to an increase fracture unclear. We have used General Practice Research Database perform case-control analysis, including 16,341 cases hip (mean age 79 years, 79% female, median period prescribing data 2.7 years) and 29,889 control subjects, individually matched by age, sex, general practice. Data for all prescriptions potential...