A5074141429- Cystic Fibrosis Research Advances
- Fatty Acid Research and Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Child Nutrition and Feeding Issues
- Infections and bacterial resistance
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Nutritional Studies and Diet
- Diet and metabolism studies
- Breastfeeding Practices and Influences
- Malaria Research and Control
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Meat and Animal Product Quality
- Infectious Encephalopathies and Encephalitis
- Tracheal and airway disorders
- Genetic Syndromes and Imprinting
- Urological Disorders and Treatments
- Consumer Attitudes and Food Labeling
- Nonmelanoma Skin Cancer Studies
- RNA Research and Splicing
- Salmonella and Campylobacter epidemiology
- IgG4-Related and Inflammatory Diseases
- Pleural and Pulmonary Diseases
- Brucella: diagnosis, epidemiology, treatment
Royal Alexandra Children's Hospital
2011-2024
Bridge University
2023
University of Cambridge
2021-2023
University of Manitoba
2017
Manchester Metropolitan University
2012-2015
University of Toronto
2013-2015
Leeds Beckett University
2015
Louisiana State University in Shreveport
2013
University of Nottingham
2002-2012
Nottingham City Hospital
2007-2012
This is the second in a series of four papers updating European Cystic Fibrosis Society (ECFS) standards for care people with CF. paper focuses on establishing and maintaining health. The guidance produced using an evidence-based framework wide stakeholder engagement, including from CF community. Authors provided narrative description their topic statements, which were more directive. These statements reviewed by Delphi exercise, achieving good levels agreement group all statements....
The etiology of allergic disease is not understood, but a decreased exposure to infection may play an important role. There are few published data on the impact change in microbial during pregnancy child's risk developing disease. Using birth cohort 24,690 children, derived from West Midlands General Practice Research Database, we investigated number perinatal exposures incidence asthma, eczema, and hay fever. Our findings suggest that antibiotics utero associated with increased asthma...
Rationale: Previous studies have suggested that people with idiopathic pulmonary fibrosis (IPF) may be at increased risk of vascular disease.Objectives: To quantify the cardiovascular disease before and after a diagnosis IPF.Methods: We used computerized primary care data from Health Improvement Network to relative having event (acute coronary syndrome, angina, atrial fibrillation, deep-vein thrombosis, cerebrovascular accident) either or IPF in comparison age, sex, community-matched general...
Abstract We determined the trends in incidence of skin basal cell carcinoma (BCC) using a primary care population‐based cohort study UK. 11,113 adults with BCC diagnosis were identified from total 7.22 million person‐years data between 1996 and 2003 Health Improvement Network database. From random subsample cases database, 93% confirmed by hospital letter and/or pathology report. The was 153.9 per 100,000 (95% CI 151.1, 156.8) slightly higher men as compared to women (Incidence Rate Ratio...
Extrinsic allergic alveolitis (EAA) is an important clinical entity, but its incidence and significance in the general population are uncertain.To estimate of EAA, resulting mortality, UK.General-population-based cohort study a UK primary care database (THIN).THIN patients with incident diagnosis EAA were compared whose members 4:1 matched by age, sex GP practice. Follow-up started at first (and same date controls) ended death or end follow-up, whichever came first. Poisson, logistic, Cox...
Summary Global trends show that habitual omega‐3 intakes are short of recommended guidelines, particularly among vegetarians. Subsequently, alternative dietary sources long‐chain polyunsaturated fatty acids ( LC 3 PUFA ) from vegetarian needed. Food technology methods advancing, and nanoemulsion technologies have improved the bioavailability certain lipid‐based nutrients. This study examined whether ingestion an algal oil led to compared bulk oil. Eleven subjects completed a single‐blind,...
Objectives. We examined the effect of vaccination for diphtheria; polio; pertussis and tetanus; or measles, mumps, rubella on incidence physician-diagnosed asthma eczema. Methods. used a previously established birth cohort in West Midlands General Practice research database. Results. found an association between development allergic disease; however, this was present only among children with fewest physician visits can be explained by factor. Conclusions. Our data suggest that currently...
Objective: To determine whether nicotine replacement therapy (NRT) is associated with an increased risk of acute myocardial infarction, stroke, or death. Design: Self control case series analysis data from The Health Improvement Network (THIN) to estimate the relative incidence infarction and stroke in four 14 day periods before after first prescription for NRT. Setting: THIN a computerised general practice database. Subjects: Patients contributing THIN. Interventions: Observational study...
Background: antihypertensive medications have long been implicated as a potential cause of falls in older people but, despite their widespread prescribing, the size class-specific adverse effects remains unclear.
The acute and chronic leukaemias constitute about 2.5% of all newly diagnosed malignancies kill over 4000 people/year in the UK, yet there is little accurate up-to-date data on how incidence mortality from vary with socio-economic status UK. We aimed to quantify UK their variation gender, age, year diagnosis as well status.All incident cases leukaemia were identified 'The Health Improvement Network' (THIN) General Practice dataset. Crude rates rate ratios (using Poisson Regression)...
Objective: To document the prevalence of depression and examine relationship between selected pain-related variables associated with chronic back pain among elderly nonelderly samples. Design: Survey mailed questionnaire. Setting: Patients seeking treatment at a spine diagnostic center. Patients: Consecutive sample subjects (n=69).Nonelderly (n=59) were randomly to achieve size comparable elderly. Evaluation depressed mood was determined by Beck Depression Inventory. Main Outcome Measures:...
Prader–Willi syndrome (PWS) is a rare orphan disease and complex genetic neurodevelopmental disorder, with birth incidence of approximately 1 in 10,000–30,000. Management people PWS requires multi-disciplinary approach, ideally through team (MDT) clinic community support. Hypotonia, poor feeding faltering growth are characteristic features the neonatal period, followed by hyperphagia risk rapid weight gain later childhood. Children adolescents (CA) usually display developmental delay mild...
Cryptogenic fibrosing alveolitis is an interstitial lung disease of unknown etiology. Since pulmonary fibrosis a recognized, if rare, complication certain drug exposures, including antidepressants, betablockers, antibiotics, anticonvulsants, and nonsteroidal antiinflammatory drugs (NSAIDs), we tested the hypothesis that exposure to these might contribute etiology cryptogenic alveolitis. Lifetime data were collected from general practitioner records for 141 cases 246 age-, sex-,...
Coccidioides is a dimorphic fungus that causes coccidioidomycosis, also known as San Joaquin Valley Fever. The endemic to the southwestern United States, northern Mexico, and Central South America. Infection typically acquired through inhalation of dust particles pulmonary disease. Direct cutaneous inoculation can occur but rare. Histopathological examination lesions shows pseudoepitheliomatous hyperplasia with acute, suppurative granulomatous inflammation. Fungal organisms tend be found...