Marcus Chan

ORCID: 0000-0001-6072-7648
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About
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Research Areas
  • Nutrition and Health in Aging
  • Body Composition Measurement Techniques
  • Frailty in Older Adults
  • Genomics and Rare Diseases
  • Pleistocene-Era Hominins and Archaeology
  • Hemoglobinopathies and Related Disorders
  • Conservation, Biodiversity, and Resource Management
  • Cancer Genomics and Diagnostics
  • Advanced Computing and Algorithms
  • Neonatal and fetal brain pathology
  • Cellular and Composite Structures
  • Microgrid Control and Optimization
  • Genetic factors in colorectal cancer
  • Dysphagia Assessment and Management
  • Pharmaceutical studies and practices
  • Energy Efficient Wireless Sensor Networks
  • Genomic variations and chromosomal abnormalities
  • Testicular diseases and treatments
  • Land Use and Ecosystem Services
  • Airway Management and Intubation Techniques
  • Cancer and Skin Lesions
  • Wireless Body Area Networks
  • Cystic Fibrosis Research Advances
  • Electrical and Bioimpedance Tomography
  • Voice and Speech Disorders

Anahuac Mayab University
2024

Goulburn Base Hospital
2024

University of Hong Kong
2020-2022

Georgia Institute of Technology
2022

Chinese University of Hong Kong
2022

University College London
2016

The aim of this meta-analysis is to comprehensively evaluate the effects lean mass on all-cause mortality across different cancer types.This a meta-analysis. Cohort studies and published before December 20, 2017 were obtained by systematic search PubMed, Cochrane Library, Embase. Inclusion criteria cohort reporting measurements dual-energy X-ray absorptiometry, bioimpedance analysis or computed tomography, with as study outcome. Exclusion using muscle surrogates, anthropometric measurement...

10.1016/j.afos.2021.03.002 article EN cc-by-nc-nd Osteoporosis and Sarcopenia 2021-03-01

Sarcopenia is recognized to be a health problem which as serious obesity, but its relevance mortality unclear. We conducted meta-analysis of cohort studies on lean mass and in populations with different conditions. In this study, systematic search PubMed, Cochrane Library Embase was performed for published before Dec 20, 2017 examined the relationship between mortality. included reporting measurement by dual-energy X-ray absorptiometry, bioimpedance analysis or computed tomography,...

10.1016/j.afos.2021.02.001 article EN cc-by-nc-nd Osteoporosis and Sarcopenia 2021-03-01

Preemptive pharmacogenetic testing has the potential to improve drug dosing by providing point-of-care patient genotype information. Nonetheless, its implementation in Chinese population is limited lack of population-wide data. In this study, secondary analysis exome sequencing data was conducted study pharmacogenomics 1116 Hong Kong Chinese. We aimed identify spectrum actionable variants and rare, predicted deleterious that are potentially Chinese, estimate proportion dispensed drugs may...

10.1371/journal.pgen.1009323 article EN cc-by PLoS Genetics 2021-02-18

Sarcopenia has been an emerging theme in clinical oncology. Various definitions of sarcopenia have proposed, but their prognostic performance yet to be evaluated and compared. The aim this meta-analysis is comprehensively evaluate the different cutoff cancer mortality prognostication. This a meta-analysis. Cohort studies on lean mass published before December 20, 2017 were obtained by systematic search PubMed, Cochrane Library, Embase. Inclusion criteria cohort reporting binary categorized...

10.1016/j.afos.2021.02.005 article EN cc-by-nc-nd Osteoporosis and Sarcopenia 2021-03-01

Traditional carrier screening has been utilized for the detection of carriers genetic disorders. Since a comprehensive assessment frequencies recessive conditions in Southern Chinese population is not yet available, we performed secondary analysis on spectrum and status 315 genes causing autosomal disorders 1543 individuals with next-generation sequencing data, 1116 exome 427 genome data. Our data revealed that 1 2 people (47.8% population) was one or more conditions, 12 (8.30% treatable...

10.1038/s41525-022-00287-z article EN cc-by npj Genomic Medicine 2022-03-21

Muscle mass is one of the key components in defining sarcopenia and known to be important for locomotion body homeostasis. Lean commonly used as a surrogate muscle has been shown associated with increased mortality. However, relationship lean mortality may affected by different clinical conditions, modalities used, cut-off point define low or normal mass, even types cancer among patients. Thus, we aim perform comprehensive meta-analysis considering all these factors.Systematic search was...

10.1016/j.afos.2021.01.001 article EN cc-by-nc-nd Osteoporosis and Sarcopenia 2021-02-11

Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There a clinical need for techniques to provide cotside assessment of the injury extent. This study aims use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination systemic physiology assess severity HIE injury. Broadband NIRS used measure changes haemodynamics, oxygenation oxidation state cytochrome c oxidase (oxCCO). We canonical correlation...

10.1007/978-3-319-38810-6_24 article EN cc-by Advances in experimental medicine and biology 2016-01-01

Abstract Background Chromosomal microarray (CMA) has been shown to be cost-effective over karyotyping in invasive prenatal diagnosis for pregnancies with fetal ultrasound anomalies. Yet, information regarding preceding and subsequent tests must considered as a whole before the true cost-effectiveness can emerge. Currently Hong Kong, is offered free standard test while genome-wide array comparative genome hybridization (aCGH), form of CMA, self-financed. A new algorithm was proposed use aCGH...

10.1186/s12884-020-2772-y article EN cc-by BMC Pregnancy and Childbirth 2020-02-14

Currently, there is no robust evidence demonstrating a clear association between Lynch syndrome and non-malignant breast pathology such as adenomyoepithelioma. We report case of benign adenomyoepithelioma, which after recurrence was associated with ductal carcinoma in-situ (DCIS) in 41-year-old woman syndrome, who lacked significant family history or ovarian cancer. Both, the adenomyoepithelioma DCIS were found to have nuclear loss MSH2/MSH6 by immunohistochemistry, while germline testing...

10.1177/10668969241226704 article EN International Journal of Surgical Pathology 2024-01-31

10.14309/01.ajg.0001042884.76877.5e article EN The American Journal of Gastroenterology 2024-10-01

Introduction: Cystic intratesticular lesions can occur in the second and fourth decades of life are typically identified via ultrasound. Testicular cysts, usually under 2 cm, result from epididymal-lymphatic obstruction or hormonal changes. Larger with sperm lymphocytes spermatoceles. Epididymal cysts asymptomatic but cause discomfort pain, sometimes requiring surgery. Clinical case: A 38-year-old male no chronic diseases presented a giant tumor right testicle, experiencing pain...

10.47191/ijmscrs/v4-i10-37 article EN cc-by International Journal of Medical Science and Clinical Research Studies 2024-10-30

<h3>Background</h3> Pharmacogenetics is the study of variability in drug response caused by genetic variations. It estimated that over two million hospitalized patients develop severe adverse reactions United States annually, incurring a direct medical cost 200 billion US dollars (USD). This indicates huge potential reducing healthcare costs even if only small proportion are preventable genotype-guided prescription. The current clinical applications pharmacogenetics mostly limited to...

10.1136/bmjpo-2021-rcpch.61 article EN Abstracts 2021-04-01

In this work, a 60GHz real-time tracking system utilizing an ultra-low-cost and compact mmID-enabled is characterized. The characterized consists of ultra-lowcost Antenna on Package (AoP) FMCW radar mmID tag. leverages the use on-chip processing high-fidelity ranging enabled through mm-Wave module providing probability detection greater than 0.9 at 35cm from bounded average error standard deviation 1.36 cm 2.01 cm, respectively. Additionally, angular coverage was displays ±15° with 80%....

10.1109/orss55359.2022.9806033 article EN 2022-04-27
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