A5043856880- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Neuroscience of respiration and sleep
- Optical Imaging and Spectroscopy Techniques
- Thermal Regulation in Medicine
- Infant Development and Preterm Care
- Non-Invasive Vital Sign Monitoring
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Autopsy Techniques and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Forensic Anthropology and Bioarchaeology Studies
- Atomic and Subatomic Physics Research
- Prenatal Screening and Diagnostics
- Prostate Cancer Treatment and Research
- Neonatal and Maternal Infections
- Forensic Entomology and Diptera Studies
University College London
2016-2025
London Women's Clinic
2016-2025
University of Edinburgh
1999-2024
University College Hospital
2007-2022
St. Paul's Hospital
2021
University of British Columbia
2021
Roslin Institute
2021
GlaxoSmithKline (United Kingdom)
2020-2021
University College London Hospitals NHS Foundation Trust
2008-2020
The Royal Free Hospital
2004-2020
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for study and treatment several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), cause Huntington's disease (HD), is at very low levels CSF and, to our knowledge, never measured previously.
Despite treatment with therapeutic hypothermia, almost 50% of infants neonatal encephalopathy still have adverse outcomes. Additional treatments are required to maximize neuroprotection. Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic–ischaemic brain injury animal models. The objective this study was assess effects combining melatonin hypothermia after transient hypoxia–ischaemia piglet model perinatal...
BackgroundModerate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit. We assessed whether the addition of xenon gas, a promising novel therapy, initiation hypothermia for would result improvement.MethodsTotal Body plus Xenon (TOBY-Xe) was proof-of-concept, randomised, open-label, parallel-group trial done at four intensive-care neonatal units UK. Eligible infants were 36–43 weeks gestational...
This review discusses an approach to determining the cause of neonatal encephalopathy, as well current evidence on resuscitation and subsequent management hypoxic-ischaemic encephalopathy (HIE). Encephalopathy in neonates can be due varied aetiologies addition hypoxic-ischaemia. A combination careful history, examination judicious use investigations help determine cause. Over last 7 years, infants with moderate severe HIE have benefited from introduction routine therapeutic hypothermia;...
Background. There is extensive experimental evidence to support the investigation of treatment with mild hypothermia after birth asphyxia. However, clinical studies have been delayed by difficulty in predicting long-term outcome very soon and concern about adverse effects hypothermia. Objectives. The objectives this study were determine whether it feasible select infants a bad neurological prognosis begin hypothermic therapy within 6 hours birth, observe effect on relevant physiologic...
Abstract Objective: Additional treatments for therapeutic hypothermia are required to maximize neuroprotection perinatal asphyxial encephalopathy. We assessed neuroprotective effects of combining inhaled xenon with after transient cerebral hypoxia–ischemia in a piglet model asphyxia using magnetic resonance spectroscopy (MRS) biomarkers supported by immunohistochemistry. Methods: Thirty‐six newborn piglets were randomized (all groups n = 9), intervention from 2 26 hours, to: (1)...
We present a novel lens-based broadband near-infrared spectroscopy system to simultaneously measure cerebral changes in tissue oxygenation and haemodynamics via estimation of the haemoglobin concentration; addition oxygen utilization measurement oxidation state cytochrome-c-oxidase (CCO). demonstrate use cohort 6 newborn infants with neonatal encephalopathy Neonatal Intensive Care Unit for continuous periods up 5 days. NIRS data was collected from above frontal lobe on left right hemispheres...
Background and Purpose— In infants with moderate to severe neonatal encephalopathy, whole-body cooling at 33°C 34°C for 72 hours is standard care a number needed treat prevent adverse outcome of 6 7. The precise brain temperature providing optimal neuroprotection unknown. Methods— After quantified global cerebral hypoxic-ischemic insult, 28 piglets aged <24 were randomized (each group, n=7) (1) normothermia (38.5°C throughout) or 2 26 after insult (2) 35°C, (3) 33.5°C, (4) 30°C. At 48...
Minimally invasive autopsy by post mortem magnetic resonance (MR) imaging has been suggested as an alternative for conventional in view of the declining consented rates. However, large prospective studies rigorously evaluating accuracy such approach are lacking. We intend to compare a minimally using MR with that fetuses, newborns and children detection major pathological abnormalities and/or determination cause death.We recruited 400 consecutive referred one two participating hospitals over...