A5002564649- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Body Composition Measurement Techniques
- Heart Rate Variability and Autonomic Control
- Cancer-related molecular mechanisms research
- Cardiovascular Syncope and Autonomic Disorders
- Dementia and Cognitive Impairment Research
- Hormonal Regulation and Hypertension
- Frailty in Older Adults
- Regulation of Appetite and Obesity
- Advanced Glycation End Products research
- Acute Ischemic Stroke Management
- Renin-Angiotensin System Studies
- Atherosclerosis and Cardiovascular Diseases
- Medical Imaging and Pathology Studies
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
Ehime University
2016-2025
University of Oxford
2023
Nagoya University
2023
Center for Environmental Health
2023
Population Health Research Institute
2023
Hamilton Health Sciences
2023
McMaster University
2023
National University Health System
2023
University Medical Center Utrecht
2017
Jikei University School of Medicine
2017
To develop a risk score that estimates 3-year and 5-year absolute risks for aneurysm growth.From 10 cohorts of patients with unruptured intracranial aneurysms follow-up imaging, we pooled individual data on sex, population, age, hypertension, history subarachnoid hemorrhage, location, size, aspect ratio, shape but not smoking during family in 1,507 1,909 used growth as outcome. With aneurysm-based multivariable Cox regression analysis, determined predictors growth, which were presented to...
When increased in vascular tissues, angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that hydrolyzes angiotensin II to angiotensin-(1-7), may augment the growth inhibitory and vasodilatory effects of heptapeptide. We investigated regulation ACE2 angiotensin-(1-7) expression aortas carotid arteries 12-wk-old male spontaneously hypertensive rats (SHR) by determining effect sustained type 1 (AT(1)) receptor blockade with olmesartan (10 mg.kg(-1).day(-1), n = 13) compared those...
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
The combination of sarcopenia, age-related loss muscle strength and mass, obesity has been recognized as a new category among the elderly. Given that leptin hypothesized to be involved in pathogenesis sarcopenic obesity, we investigated relationship between plasma levels thigh sarcopenia visceral obesity. Thigh cross-sectional area (CSA) fat were measured using computed tomography indices for mass fat, respectively, 782 middle-aged elderly subjects (303 men 479 women), participating medical...
Abstract Background There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to development impairment unclear. We investigated possible muscle mass decline in cross‐sectional study 1518 subjects aged 55 years or above. also evaluated arterial stiffness white matter hyperintensities (WMHs) as mechanisms for this association. Methods Two sarcopenic indices were measured: thigh area (CSA; calculated by computed tomography)...
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide produced by endothelial and smooth muscle cells. Many lines of biological evidence suggest that the ET-1 gene candidate for hypertension. Moreover, recent association studies suggested G/T polymorphism with an amino acid substitution (Lys/Asn) at codon 198 in exon 5 interacts body mass index (BMI) blood pressure. They T carriers are more sensitive to weight gain than GG homozygotes However, often irreproducible, first study suggests...
Abstract —To elucidate the relationship between postprandial hypotension (PPH) and asymptomatic cerebrovascular damage, we evaluated changes in blood pressure after a meal by 24-hour monitoring 70 hospitalized essential hypertensive patients aged ≥50 years. They received diet containing standard nutritional ingredients with 120 mmol (7 g) NaCl were free from medication for at least 1 week. PPH was defined as mean reduction of systolic during 2 hours meal. Patients divided into three groups...
Aim: Aging shifts body composition to comprising more fat and less muscle. Sarcopenia, particularly in the knee extensors, obesity, visceral either alone or combination, may exacerbate age‐related physical disability. We investigated association between quadriceps (Qc) sarcopenia as measured by cross‐sectional area (CSA), on postural instability. Methods: Mid‐thigh muscle CSA abdominal subcutaneous at level of umbilicus were assessed from computed tomography (CT) images 410 apparently...
<i>Background/Aims:</i> Mobility impairment in older adults has been suggested to be a marker of subclinical structural and functional brain abnormalities. We investigated possible association between static postural instability abnormalities cognitive decline. <i>Methods:</i> The study subjects were 390 community residents without definitive dementia (67 ± 7 years old) 21 patients with Alzheimer’s disease (AD). Brain atrophy was measured by MRI....
<i>Background/Aim:</i> Lower body weight in later life has been shown to be associated with dementia. However, abdominal fat distribution under conditions of mild cognitive impairment (MCI) and the possible involvement leptin adiponectin MCI have not fully investigated. <i>Methods:</i> We analyzed 517 middle-aged-to-elderly community-dwelling persons. Abdominal subcutaneous visceral areas were determined using computed tomography, plasma concentrations measured...
Variants in the CDH13 gene have been identified as determinants of blood levels adiponectin, an insulin-sensitizing adipokine. However, their association with other metabolic risk factors remains unclear. We examined variants at relation to total and high-molecular-weight (HMW) adiponectin using data from a genome-wide study performed 2,434 Singaporean Chinese replication up 3,290 Japanese 1,610 Koreans. The top signal rs4783244 showed strong associations (standardized β [β] = -0.34, 95% CI...
Hypertension (HT) and dementia are common disorders in the elderly. HT elderly is associated with increased occurrence rates of including Alzheimer's disease (AD) vascular (VaD). In connection to this, some studies have suggested that old age correlates pathogenesis dementia. Since potentially reversible, a number randomized trials examined whether antihypertensive treatment may help preventing occurrence. We review five studies, all using subjects 60 years or older, which investigated...
Objective: Increasing blood pressure (BP) variability is reported to be a cardiovascular risk factor. However, the clinical implications of postprandial hypotension (PHYPO), commonly observed BP in elderly persons, are poorly understood. Here, we investigated possible associations between decline and asymptomatic cerebral damage community residents. Methods: Study participants consisted 1308 general residents (65 ± 9 years old). Postprandial change was calculated from SBP measured just...
Sarcopenia is defined as a combination of low skeletal muscle mass index (SMI), weak strength, and reduced physical function. Recently, many studies have reported that the creatinine/cystatin C ratio (Cr/CysC) useful for evaluating mass. We designed cross-sectional study with separate model development validation groups to develop prediction equation estimate bioimpedance analysis (BIA)-measured SMI Cr/CysC.The current was retrospective study.The group included 908 subjects (288 men 620...
One-leg standing time (OLST) has been frequently used physical performance measure; however, what muscular characteristics OLST represents remains uncertain. This cross-sectional study aimed to investigate the association between and muscle clarify possibility of using as a measure. Study participants comprised 1144 older adults aged 65 years or older. Computed tomography images provided mid-thigh skeletal area mean attenuation value. was measured for maximum 60 s. Static postural...