A5100425161- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Genetic Associations and Epidemiology
- Corneal surgery and disorders
- Spectral Theory in Mathematical Physics
- Matrix Theory and Algorithms
- Ophthalmology and Eye Disorders
- Cancer-related molecular mechanisms research
- Image and Signal Denoising Methods
- Bayesian Methods and Mixture Models
- Differential Equations and Boundary Problems
- Advanced Optimization Algorithms Research
- Genetic and phenotypic traits in livestock
- Optical Coherence Tomography Applications
- Speech and Audio Processing
- Advanced Adaptive Filtering Techniques
- RNA modifications and cancer
- Statistical Methods and Bayesian Inference
- Advanced Differential Equations and Dynamical Systems
- Ultrasonics and Acoustic Wave Propagation
- Thermography and Photoacoustic Techniques
- Polynomial and algebraic computation
- Metabolomics and Mass Spectrometry Studies
- Statistical Distribution Estimation and Applications
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Tianjin Fire Research Institute
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Chengdu Research Base of Giant Panda Breeding
2024
National University of Singapore
2005-2023
Southern University of Science and Technology
2023
Singapore National Eye Center
2016-2021
Singapore Eye Research Institute
2015-2021
Capital University
2021
Given that the neural and connective tissues of optic nerve head (ONH) exhibit complex morphological changes with development progression glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be great interest for clinical diagnosis management this pathology. A deep learning algorithm (custom U-NET) was designed trained to segment 6 ONH tissue layers by capturing both local (tissue texture) contextual information (spatial arrangement tissues). The overall...
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and leading cause visual impairment in working-age adults. Patients with often develop DR despite appropriate control systemic risk factors, suggesting involvement other pathogenic factors. We hypothesize that plasma metabolic signature distinct resolvable from alone. A nested population-based case-control metabonomic study was first performed on 40 cases subjects using gas chromatography-mass spectrometry....
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
Previous studies have suggested that the lamina cribrosa (LC) and its surrounding sclera are biomechanically important in pathogenesis of glaucoma, but many were limited by assumptions tissue isotropy homogeneity. Here, we used an improved biomechanical model driven experimental measurements scleral LC collagen fiber organization to more accurately evaluate optic nerve head (ONH) biomechanics.Collagen was quantitatively mapped across human ONH cryosections (three normal three glaucomatous)...
Purpose: To remove blood vessel shadows from optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: Volume scans consisting 97 horizontal B-scans were acquired through center ONH using a commercial OCT device for both eyes 13 subjects. A custom generative adversarial network (named DeshadowGAN) was designed and trained with 2328 in order to unseen B-scans. Image quality assessed qualitatively (for artifacts) quantitatively intralayer contrast—a measure shadow...
To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation healthy, glaucoma, and ocular hypertensive subjects.There were 20 high-tension primary open-angle glaucoma (POAG), 16 angle-closure (PACG), (OHT; with normal visual fields) eyes studied. For each test eye, the optic nerve head was imaged three times (at baseline IOP, an of to approximately 35 then 45 mm Hg using ophthalmodynamomter) optical coherence tomography (OCT). A three-dimensional (3D)...
In current approaches to vision screening in the community, a simple and efficient process is needed identify individuals who should be referred tertiary eye care centres for loss related diseases. The emergence of deep learning technology offers new opportunities revolutionise this clinical referral pathway. We aimed assess performance newly developed algorithm detection disease-related visual impairment.In proof-of-concept study, using retinal fundus images from 15 175 eyes with complete...
Recently proposed deep learning (DL) algorithms for the segmentation of optical coherence tomography (OCT) images to quantify morphological changes optic nerve head (ONH) tissues during glaucoma have limited clinical adoption due their device specific nature and difficulty in preparing manual segmentations (training data). We propose a DL-based 3D framework that is easily translatable across OCT devices label-free manner (i.e. without need manually re-segment data each device). Specifically,...
"Dry eye" is a multifactorial inflammatory disease affecting the ocular surface. Tear hyperosmolarity in dry eye contributes to inflammation and cell damage. Recent research efforts on have been directed toward biomarker discovery for diagnosis, response treatment, mechanisms. This study employed spontaneously immortalized normal human conjunctival line, IOBA-NHC, as model investigate hyperosmotic stress-induced changes of metabolites proteins. Global targeted metabonomic analyses well...
Background To estimate and compare changes in the Bruch’s membrane opening—minimum rim width (BMO–MRW) area normal, ocular hypertensive glaucoma eyes following acute elevations intraocular pressure (IOP). Methods The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 hypertension (OHT) 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0.64 n then 0.9 n)...
To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies.
To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina lamina cribrosa (LC) in vivo.Clinical data 20 healthy, ocular hypertensive (OHT), primary open-angle glaucoma, 16 angle-closure glaucoma eyes were analyzed. For each eye, intraocular pressure (IOP) optical coherence tomography (OCT) images optic nerve head (ONH) acquired at normal state after acute IOP elevation. The IOP-induced deformation ONH was obtained from OCT volumes using...
The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian White populations. We analysed two population-based cohorts, composing 1,221 Asians (SEED) 703 (WESDR) adults with diabetes. Retinal at baseline included vascular caliber (arteriolar-CRAE, venular-CRVE) retinopathy (DR). Incident cases DKD were identified after ~ 6-year. defined based on eGFR SEED proteinuria or history renal dialysis WESDR....
<h3>Importance</h3> Cataracts and diabetic retinopathy (DR) are the leading causes of acquired blindness worldwide. Although extraction is standard treatment option for cataracts, it also reported to increase risk developing DR among individuals with diabetes. Nevertheless, association between cataract surgery still not well understood, there have been no prior population-based reports in this area. <h3>Objective</h3> To assess after type 2 <h3>Design, Setting, Participants</h3> A...
Acoustic deformation potential (ADP) quantifies carrier-acoustic phonon coupling and is essential for dissecting transport physics in thermoelectrics. Herein, we report the use of ultrafast spectroscopy coherent acoustic phonons (CAPs) to characterize ADP thermoelectric materials, using ${\mathrm{Mg}}_{3}{\mathrm{Sb}}_{2}$ as an example. The photon energy-dependent amplitudes CAP-induced oscillatory reflectance were used determine constant, agreeing well with that from first-principles...