Akira Narita
A5012113903- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Antibiotics Pharmacokinetics and Efficacy
- Birth, Development, and Health
- Nutritional Studies and Diet
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Pharmaceutical studies and practices
- Advanced Chemical Physics Studies
- Neonatal Health and Biochemistry
- Sodium Intake and Health
- Nutrition, Genetics, and Disease
- Posttraumatic Stress Disorder Research
- Metabolism and Genetic Disorders
- Genomic variations and chromosomal abnormalities
- Disaster Response and Management
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Liver Disease Diagnosis and Treatment
- Rare-earth and actinide compounds
- Pregnancy and preeclampsia studies
- Bioinformatics and Genomic Networks
- Advanced Physical and Chemical Molecular Interactions
- Blood Pressure and Hypertension Studies
- Gestational Diabetes Research and Management
Tohoku Medical Megabank Organization
2015-2025
Tohoku University
2015-2025
Tokyo High School
1991-2021
Tokyo Institute of Technology
2021
Japanese Red Cross Narita Hospital
2018-2019
Akira (France)
2018-2019
South Texas Accelerated Research Therapeutics
2017
Start Treatment & Recovery Centers
2017
Start
2016
Nagoya University
2014
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, total number of patients osteoarthritis estimated to reach billion worldwide 2 As no disease-modifying treatments exist for osteoarthritis, a better understanding disease aetiopathology urgently needed. Here we perform genome-wide association study meta-analyses across up 489,975 cases 1,472,094 controls, establishing 962 independent associations,...
The existence of familial aggregation mandibular prognathism (MP) suggests that genetic components play an important role in its etiology. In this study, a genome-wide linkage analysis to identify loci susceptible MP was conducted with 90 affected sibling-pairs 42 families, comprised 40 Korean and 50 Japanese sibling-pairs. Two non-parametric analyses, GENEHUNTER-PLUS SIBPAL, were applied detected nominal statistical significance at chromosomes 1p36, 6q25, 19p13.2. best evidence near D1S234...
Social capital has been considered an important factor affecting mental-health outcomes, such as psychological distress in post-disaster settings. Although disaster-related house condition and displacement could affect both social distress, limited studies have investigated interactions. This study aimed to examine the association between taking into consideration interaction of after Great East Japan Earthquake 2011.Using data from 3793 adults living Shichigahama, Miyagi Prefecture, Japan,...
Abstract Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have power elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm number of 15 based on phenotypic variables from Simons Simplex Collection (SSC). As preliminary study, we conventional genome-wide association (GWAS) data set...
Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K self-monitoring device using spot urine established recently. Here, we assessed whether urinary change measured BP in a health checkup setting. We targeted 12,890 participants who attended Tome City, Miyagi between 2017 and 2018. City introduced measurements during checkups since 2017. For each year, compared baseline characteristics according level. relationship multiple regression...
Abstract No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic lifestyle risks with home hypertension. We examined associations combined hypertension In cross-sectional study 7027 Japanese individuals aged ≥20 years, we developed body mass index, alcohol consumption, physical activity, sodium-to-potassium ratio, categorized into ideal, intermediate, poor lifestyles. A was target data ( n = 1405) using...
Abstract Massively parallel sequencing of target regions, exomes, and complete genomes has begun to increase the opportunities for identifying genetic variants underlying rare common diseases dramatically. Here we applied exome resequencing primary failure tooth eruption (PFE) identify causality disease. Two Japanese families having PFE were recruited examined by genome-wide linkage study subsequently analyses. Linkage analyses these two comprising eight affected individuals unaffected...
Since the Great East Japan Earthquake in 2011, many of affected have been forced to live temporary housing or at a relative's house. Special attention needs be paid negative health impacts resulting from such changes living conditions. This study examined association between future prospects and risk psychological distress 1 year after earthquake.In 2012, questionnaire was completed by cross-sectional people aged 20 years older Shichigahama Town, Miyagi, northeastern Japan, an area that had...
Ethnic-specific SNP arrays are becoming more important to increase the power of genome-wide association studies in diverse population. In Tohoku Medical Megabank Project, we have been developing a series Japonica Arrays (JPA) for genotyping participants based on reference panels constructed from whole-genome sequence data Japanese Here, designed novel version array population, called Array NEO (JPA NEO), comprising total 666,883 markers. Among them, 654,246 tag SNPs autosomes and X...
The purpose of this study was to report the basic profile Miyagi Prefecture part a repeated center-based survey during second period Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well participants' characteristics based on their participation type in baseline survey.
Abstract Aims/hypothesis Clustering-based subclassification of type 2 diabetes, which reflects pathophysiology and genetic predisposition, is a promising approach for providing personalised effective therapeutic strategies. Ahlqvist’s classification currently the most vigorously validated method because its superior ability to predict diabetes complications but it does not have strong consistency over time requires HOMA2 indices, are routinely available in clinical practice standard cohort...
It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, Dietary Inflammatory Index (DII®) was developed to assess inflammatory potential overall The DII as relevant various but not validated Japanese. Thus, present study, we analyzed relationship between scores high-sensitivity C-reactive protein (hs-CRP) levels a Japanese population.Data National Integrated Project for Prospective...