A5062567082- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Sodium Intake and Health
- Disaster Response and Management
- Health, Environment, Cognitive Aging
- Nutrition and Health in Aging
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Geriatric Care and Nursing Homes
- Birth, Development, and Health
- Diet and metabolism studies
- Posttraumatic Stress Disorder Research
- Homelessness and Social Issues
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Sleep and related disorders
- Disaster Management and Resilience
- Renal function and acid-base balance
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Risk Factors
- Climate Change and Health Impacts
- Nutrition, Genetics, and Disease
Tohoku Medical Megabank Organization
2015-2025
Tohoku University
2013-2025
Tohoku University Hospital
2024
General Department of Preventive Medicine
2024
Graduate School USA
2023
Gunma University
1987
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines Management Hypertension. However, large-scale studies on association smoking, potassium excretion, and gamma-glutamyl transferase level with BP population are limited. We conducted a cross-sectional study to examine between risk systolic blood pressure Tohoku Medical Megabank Community-based Cohort Study (23,446 men 38,921 women aged ≥20 years). A model adjusted age, body mass...
Epidemiological studies have demonstrated that the urine sodium-to-potassium (Na/K) ratio is more positively associated with high blood pressure and cardiovascular disease risk than either sodium or potassium excretion alone. In this consensus statement, we recommend using average Na/K of casual urines randomly taken in various times on at least four days a week for reliable individual estimate because day-to-day intraday variability within individuals. Although continuous positive...
Social capital has been considered an important factor affecting mental-health outcomes, such as psychological distress in post-disaster settings. Although disaster-related house condition and displacement could affect both social distress, limited studies have investigated interactions. This study aimed to examine the association between taking into consideration interaction of after Great East Japan Earthquake 2011.Using data from 3793 adults living Shichigahama, Miyagi Prefecture, Japan,...
Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K self-monitoring device using spot urine established recently. Here, we assessed whether urinary change measured BP in a health checkup setting. We targeted 12,890 participants who attended Tome City, Miyagi between 2017 and 2018. City introduced measurements during checkups since 2017. For each year, compared baseline characteristics according level. relationship multiple regression...
Abstract No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic lifestyle risks with home hypertension. We examined associations combined hypertension In cross-sectional study 7027 Japanese individuals aged ≥20 years, we developed body mass index, alcohol consumption, physical activity, sodium-to-potassium ratio, categorized into ideal, intermediate, poor lifestyles. A was target data ( n = 1405) using...
The purpose of this study was to report the basic profile Miyagi Prefecture part a repeated center-based survey during second period Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well participants' characteristics based on their participation type in baseline survey.
Background: The relationship between blood cell profiles, including hemoglobin (Hb) levels and inflammatory hematological ratios, mental health problems currently remains unclear. Aim: This study aimed to investigate the profiles issues, depressive state sleep disturbance, while adjusting for potential demographic confounders. Methodology: retrospective, cross-sectional, observational used a population-based medical database from Tohoku Medical Megabank Project with more than 60,000...
Abstract Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) more reproducible accurately predictive of diseases than office BP. Therefore, we focused on home BP investigated whether contributed to future onset HT. This prospective cohort study used data from Tohoku Medical Megabank Community-Cohort Study (conducted in Miyagi Prefecture,...
Abstract This study aimed to investigate the association of combination birth weight and current body mass index (BMI) with risk hypertension in adulthood. cross-sectional used data from Tohoku Medical Megabank Community-based Cohort Study conducted Japan. A total 10,688 subjects aged ≥20 years were eligible. We calculated least square (LS) means systolic blood pressure (SBP) trend tests performed evaluate linear relationships between categories SBP. also a multivariate logistic regression...
Abstract Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism unknown. This study aimed to elucidate profile white blood cells (WBCs) in acute phase an MS attack. Sixty-four patients with at time diagnosis and 2492 age- sex-adjusted healthy controls (HCs) were enrolled. Data regarding cell counts compared between groups. The total WBC ( p < 0.0001), monocyte basophil = 0.0027), neutrophil 0.0001) higher group than HC group,...
The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake low potassium are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the between sodium- potassium-related urinary markers prevalence. Data from Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study....
Background Natural disasters may have negative health effects on survivors. However, long-term observations this are lacking. Therefore, study investigated the association between degree of housing damage caused by Great East Japan Earthquake (GEJE) and all-cause mortality using data from cohort conducted Tohoku Medical Megabank (TMM) Project in disaster-stricken areas. Methods The community-based TMM which a baseline survey May 2013 to March 2016 collected questionnaires blood urine tests....
Objectives Previous studies have assessed the impact of active smoking on mortality using population-attributable fraction (PAF). However, these not included second-hand (SHS), potentially underestimating smoking’s impact. We compared PAF from alone with PAF, including SHS exposure. Design Prospective cohort study. Setting A community-based study in Japan. Participants 40 796 participants aged ≥20 years. Main outcome measures was defined as inhaling someone else’s cigarette smoke at...
ABSTRACT Objectives Owing to spousal pairs often exhibiting similar health behaviors, this study examined the concordance of cancer screening attendance between spouses using cross‐sectional data from a large biobank in Japan, which included 2022 pairs. Study Design Cross‐sectional study. Methods Self‐administered were collected determine whether participants had undergone for colorectal, gastric, and lung cancers past year. The following two analyses conducted: exposure was husband attended...
Background: Patients with physical disease are known to suffer considerable psychological distress. Social support may confound the association between and Population-based epidemiological studies have not been conducted on history of disease, distress social support. Methods: Using cross-sectional data from 2006, we studied 43 487 community-dwelling people aged ≥40 years living in Japan. We examined 13 self-reported histories evaluated using Kessler 6-item scale (K6), defined as ≥13 points...
It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, Dietary Inflammatory Index (DII®) was developed to assess inflammatory potential overall The DII as relevant various but not validated Japanese. Thus, present study, we analyzed relationship between scores high-sensitivity C-reactive protein (hs-CRP) levels a Japanese population.Data National Integrated Project for Prospective...
Abstract The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) have diurnal and day-to-day variations. Therefore, we investigated number of days required yield a better association between morning uNa/K home BP (HBP) determined that can used as in participants who are not taking antihypertensive medication. This was cross-sectional study using data from Tohoku Medical Megabank...
We examined the association between carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on Japan Atherosclerosis Society 2022 Prevention Guideline.
Abstract Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, multiple measurements of casual Na/K are more strongly correlated with 24-h than single measurement. Multiple might be associated hypertension. We aimed to determine home hypertension compared A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old participated Tohoku Medical Megabank Project Cohort...
Previous studies have reported that elderly victims of natural disasters might be prone to a subsequent decline in motor function. Victims the Great East Japan Earthquake (GEJE) relocated wide range different types housing. As evacuee lifestyle varies according type housing available them, their degree function loss also vary accordingly. However, association between postdisaster and has never been investigated. The present study was conducted investigate after GEJE victims.We prospective...