A5073041790- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Balance, Gait, and Falls Prevention
- Health disparities and outcomes
- Bone health and osteoporosis research
- Health and Wellbeing Research
- Cerebral Palsy and Movement Disorders
- Gastric Cancer Management and Outcomes
- Stroke Rehabilitation and Recovery
- Immune Response and Inflammation
- Forensic Anthropology and Bioarchaeology Studies
- Gastrointestinal Tumor Research and Treatment
- Nutritional Studies and Diet
- Marine Biology and Ecology Research
- Health and Well-being Studies
- Older Adults Driving Studies
- Isotope Analysis in Ecology
- Colorectal Cancer Treatments and Studies
- Physical Activity and Health
- Body Composition Measurement Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Aging and Gerontology Research
- Musculoskeletal pain and rehabilitation
- Pelvic floor disorders treatments
National Center for Geriatrics and Gerontology
2015-2025
Azabu University
2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2025
Fukuoka Tokushukai Hospital
1983-2024
Tohoku University
2012-2024
J. F. Oberlin University
2015-2024
WuXi AppTec (China)
2013-2024
The University of Tokyo
1978-2024
Hyogo Prefectural Amagasaki General Medical Center
2018-2023
Tokyo Metropolitan Institute of Gerontology
2007-2022
Conventionally, “elderly” has been defined as a chronological age of 65 years old or older, while those from through 74 are referred to “early elderly” and over 75 “late elderly.” However, the evidence on which this definition is based unknown. We have attempted review elderly by analyzing data long‐term longitudinal epidemiological studies, clinical pathological studies that accumulated at Tokyo Metropolitan Geriatric Hospital Institute Gerontology. Our recommendation might be starting...
Objectives To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass strength community‐dwelling elderly sarcopenic women. Design Randomized controlled trial. Setting Urban community T okyo, J apan. Participants One hundred fifty‐five women aged 75 older were defined as randomly assigned to one four groups: (exercise + AAS ; n = 38), (n 39), ( or health education HE 39). Intervention The group attended a 60‐minute comprehensive training program twice...
Background To examine the effect of multicomponent exercise program on memory function in older adults with mild cognitive impairment (MCI), and identify biomarkers associated improvement functions. Methodology/Principal Findings Subjects were 100 (mean age, 75 years) MCI. The subjects classified to an amnestic MCI group (n = 50) neuroimaging measures, other before randomization. each randomized either a or education control using ratio 1∶1. exercised for 90 min/d, 2 d/wk, 40 times 6 months....
In 1998, the first Japanese practice guidelines on osteoporosis was published. It has been updated several times, with most recent being full-scale 2011 edition and its abridged edition. The present provide information for managements of primary in postmenopausal women men over 50 years old, a summary evidence treatment secondary osteoporosis, prevention younger people.The Executive Summary is primarily based content One key changes revision criteria initiation pharmacological treatment,...
Objectives To determine the standard values of and age‐related changes in objective oral function healthy older people; compare robust, prefrail, frail association between frailty. Design Cross‐sectional analysis. Setting General community. Participants Elderly adults (≥65) from Obu Study Health Promotion for were included assigned to groups (N = 4,720). Measurements Each participant underwent detailed physical testing assess The frailty phenotype was defined according presence limitations...
To examine the relationship between physical frailty and risk of disability, to identify component(s) with most impact on disability in community-dwelling older adults.Prospective cohort study.A Japanese community.4341 adults aged ≥65 living community participated a baseline assessment from 2011 2012 were followed for 2 years.Care-needs certification national long-term care insurance (LTCI) system Japan, type (robust, prefrail, frail) subitems (slowness, weakness, exhaustion, low activity,...
To identify the relationships between physical and/or cognitive frailty and instrumental activities of daily living (IADL) functioning in community older persons.
To examine the effects of a multicomponent exercise program on cognitive function older adults with amnestic mild impairment (aMCI). Design: Twelve months, randomized controlled trial; Setting: Community center in Japan; Participants: Fifty (27 men) aMCI ranging age from 65 to 93 years (mean age, 75 years); Intervention: Subjects were into either (n = 25) or an education control group 25). exercised under supervision physiotherapists for 90 min/d, 2 d/wk, total 80 times over 12 months. The...
Objective To investigate the combined and separate effects of exercise milk fat globule membrane (MFGM) supplementation on frailty, physical function, activity level, hematological parameters in community-dwelling elderly Japanese women. Methods A total 131 frail, women over 75 years were randomly assigned to one four groups: MFGM (Ex+MFGM), placebo (Ex+Plac), supplementation, or group. The group attended a 60-minute training program twice week for three months, ingested 1g supplement pill...
Abstract Curcumin (diferuloylmethane) is a dietary phytochemical with low toxicity that exhibits growth-suppressive activity against variety of cancer cells and possesses certain chemopreventive properties. has already been the subject several clinical trials for use as treatment in human cancers. Synthetic chemical modifications curcumin have studied intensively an attempt to find molecule similar but enhanced properties curcumin. In this study, series novel analogues were synthesized...
This study sought to confirm the test-retest reliability and validity of National Center for Geriatrics Gerontology functional assessment tool (NCGG-FAT), a newly developed multidimensional neurocognitive function using tablet personal computer (PC).This included 20 community-dwelling older adults (9 females, aged 65-81 years). Participants were administered NCGG-FAT twice, separated by approximately 30 days determine reliability. To test measure, participants underwent established...
In Arabidopsis root tips cultured in medium containing sufficient nutrients and the membrane-permeable protease inhibitor E-64d, parts of cytoplasm accumulated vacuoles cells from meristematic zone to elongation zone. Also barley treated with E-64, autolysosomes pre-existing central vacuoles. These results suggest that vacuolar and/or lysosomal autophagy occurs constitutively these regions cells. 3-Methyladenine, an autophagy, inhibited accumulation such inclusions tip Such were also not...
To determine the effects of a perturbed walking exercise using bilateral separated treadmill in physically disabled elderly.Participants study were 32 long-term care facility residents and outpatients aged 66-98 yrs. Participants randomly assigned to usual group or group. Perturbed gait on continued for 6 mos. Number falls time first fall during 6-mo period, balance functions, reaction evaluated before after intervention.The showed significant improvement when compared with was 21% lower...