A5049974873- Nutrition and Health in Aging
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Intracerebral and Subarachnoid Hemorrhage Research
- Geriatric Care and Nursing Homes
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Cardiovascular Health and Disease Prevention
- Dysphagia Assessment and Management
- Chronic Kidney Disease and Diabetes
- TGF-β signaling in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Sodium Intake and Health
- Neurological and metabolic disorders
- Gout, Hyperuricemia, Uric Acid
- Health, Environment, Cognitive Aging
- Chronic Disease Management Strategies
- Clusterin in disease pathology
- Intensive Care Unit Cognitive Disorders
Taipei Veterans General Hospital
2012-2021
National Yang Ming Chiao Tung University
2011-2020
National Yang Ming University Hospital
2011-2020
Ministry of Health and Welfare
2017
A decline in physical and/or cognitive function is a common feature of aging, and frailty has been shown to be associated with impairment dementia. This study aimed evaluate the association between dynapenia, sarcopenia, among community-dwelling older people Taiwan. Data from I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Global was assessed by Mini-Mental State Examination (MMSE), whereas Chinese Version Verbal Learning Test, Boston Naming Fluency Taylor Complex Figure...
Association of frailty with adverse clinical outcomes has been reported in Western countries, but data from the Asian population are scarce. This study aimed to evaluate epidemiology among community-dwelling middle-aged and elderly explore its association musculoskeletal health Taiwan.I-Lan Longitudinal Aging Study (ILAS) were retrieved for this study. Frailty was defined by Fried's criteria; a comparison demographic characteristics, physical performance, body composition, including skeletal...
Abstract Background Insulin resistance (IR) is a known risk factor for cardiovascular disease (CVD) in non-diabetic patients through the association of hyperglycemia or associated metabolic factors. The triglyceride glucose (TyG) index, which was defined by incorporating serum and insulin concentrations, developed as surrogate marker resistance. We aimed to investigate between TyG index early phase subclinical atherosclerosis (SA) sexes. Methods I-Lan Longitudinal Aging Study (ILAS) enrolled...
Abstract Frailty is a well-recognized geriatric syndrome with various definitions and conceptual frameworks. This study aimed to use latent class analysis discover potential subtypes of pre-frail frail older people. Data from the I-Lan Longitudinal Aging Study (ILAS), community-based cohort was used for analysis. Latent applied characterize classes or subgroups different frailty phenotypes among ILAS participants targeting adults aged 65 above, capable completing 6-meter walk, without severe...
Abstract Serum uric acid level is a risk factor for cardiovascular disease (CVD). However, whether it an independent or not remains controversial. We analyzed the association between serum and risk. In total, 973 nonhypertensive nondiabetic participants in I-Lan Longitudinal Aging Study were eligible this study. Subjects divided into tertiles according to levels. The 10-year was calculated using Framingham score (FRS). subjects highest tertile of older, more likely be male, had higher...
The definition of cognitive frailty and its prediction for adverse outcome community-living older adults remains controversial. This study aims to evaluate the association between all-cause mortality among adults. Data I-Lan Longitudinal Aging Study (ILAS) were retrieved study. Frailty was defined by Fried's criteria, a series neuropsychological assessments, including Mini-Mental State Examination, Center Epidemiology Studies-Depression, delayed free recall in Chinese Version Verbal Learning...
Background and Purpose— Different distributions of cerebral microbleeds (CMBs) are associated with distinct pathological mechanisms. Lobar CMBs thought to be related amyloid angiopathy, whereas deep or infratentorial hypertensive vasculopathy. The present study aimed evaluate the effects their locations on a variety cognitive domains. Methods— Study subjects were selected from community-based I-Lan Longitudinal Aging Study. We assessed domains, including verbal memory, language, visuospatial...
To evaluate the predictive validity of sarcopenia defined by Foundation for National Institutes Health (FNIH) Sarcopenia Project among Asian older adults. Data I-Lan Longitudinal Aging Study were obtained analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable completing a 6-m walk, with life expectancy more than 6 months, not institutionalized at time data collection enrolled study. subjects 65 The outcome measures all-cause mortality composite adverse which...
The aim of this study was to evaluate the association cardiometabolic risk and frailty through a community-based aging cohort in Taiwan In total, 1839 participants (men, 47.5%; mean age 63.9 ± 9.3 years) from first wave I-Lan longitudinal study, recruited between August 2011 2013, were retrieved for analysis cross-sectional study. Frailty defined by Cardiovascular Health Study (CHS) criteria, encompassing un-intentional weight loss, slow walk speed, poor grip strength, exhaustion, low...
Abstract The aging process is accompanied by changes in the brain’s cortex at many levels. There growing interest summarizing these complex brain-aging profiles into a single, quantitative index that could serve as biomarker both for characterizing individual brain health and identifying neurodegenerative neuropsychiatric diseases. Using large-scale structural covariance network (SCN)-based framework with machine learning algorithms, we demonstrate this framework’s ability to predict age...
Both physical and cognitive deficits occur in the aging process. We operationally defined phenomenon as physio-cognitive decline syndrome (PCDS) aimed to decipher its corresponding neuroanatomy patterns neurocircuit. High resolution 3T brain magnetic resonance imaging (MRI) images from a community-dwelling longitudinal cohort were analysed. PCDS was weakness (handgrip strength) and/or slowness (gait speed) concomitant with impairment any domain (defined by 1.5 standard deviation below age,...
Functional impairment is known to be associated with higher mortality risk and adverse health outcomes. However, little about whether functional decline could predict among the elderly in long-term care setting. This a prospective cohort study two veteran homes northern Taiwan active use of minimum data set (MDS). Evaluation tools retrieved from MDS, including MDS Resource Utilization Group-III for Activities Daily Living (RUG-III ADL), Cognitive Scale, Social engagement, triggers resident...
Sarcopenia, a well-known geriatric syndrome, is defined as the age-related loss of muscle mass plus declined function (muscle strength and/or physical performance). Sarcopenia associated with number adverse outcomes, including poor quality life, falls, disability, and mortality. The clinical impact sarcopenia on older people will escalate along rapid growth elderly population in Asia. Moreover, differences ethnic backgrounds between Asian Westerners have trigger need for specific diagnostic...
Aging is featured by the complex interrelationship among body composition, frailty status, and physical performance. The main aim of this study was to evaluate association serum insulin-like growth factor-1 (IGF-1), function community-dwelling middle-aged elderly population in Taiwan. We conducted a cross-sectional using data I-Lan Longitudinal Study, which recruited total 1833 people aged more than 50 years. Data lean mass (LBM), appendicular skeletal muscle (ASM), fat (TFM), bone mineral...
Abstract Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed investigate the relationship between frailty using cross-sectional data among community-dwelling middle-aged older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine urine creatinine ratio [UACR] <30 mg/g) were...
Objectives The main aim was to investigate the complex inter-relationship between frailty and pain, mediating roles of cognitive function, morbidity mood in this nexus. Design A cross-sectional analysis. Setting prospective community-dwelling population-based cohort. Participants 1682 adults age ≥50 years without evident or functional impairment, history cancer. Primary secondary outcome measures effect depression, function comorbidity on nexus pain among older middle-aged adults. Results...
The main aim of this study was to explore the association between skeletal muscle mass and function by three different measures bioactive testosterone, as well dehydroepiandrosterone sulfate (DHEA-S) among men women aged 50 years older in Taiwan facilitate further investigations sarcopenia androgen profile.The data 532 participants (mean age 64.6±9.5 years; male, 53.0%) recruited from I-Lan Longitudinal Aging Study retrieved for analysis. Appendicular mass, grip strength, walking speed were...