A5102971912- Bone health and osteoporosis research
- Bone health and treatments
- Estrogen and related hormone effects
- Bone Metabolism and Diseases
- Menopause: Health Impacts and Treatments
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Phytoestrogen effects and research
- Bone and Joint Diseases
- Pregnancy and preeclampsia studies
- Hip and Femur Fractures
- Alkaline Phosphatase Research Studies
- Pregnancy-related medical research
- Animal Virus Infections Studies
- Endometrial and Cervical Cancer Treatments
- Nutritional Studies and Diet
- Growth Hormone and Insulin-like Growth Factors
- Cancer Diagnosis and Treatment
- Uterine Myomas and Treatments
- Pelvic floor disorders treatments
- Lipoproteins and Cardiovascular Health
- Angiogenesis and VEGF in Cancer
- Cancer Treatment and Pharmacology
Meiji Pharmaceutical University
2023-2025
Kawasaki Medical School
2021-2024
Fujita Health University
2020-2024
Kawasaki Medical School Hospital
2021-2022
Fujita Health University Hospital
2021-2022
Sanno Medical Center
2010-2021
Sendai Medical Center
2021
International University of Health and Welfare
2011-2020
Yamaguchi Red Cross Hospital
2017
Prefectural University of Hiroshima
2016
In 1998, the first Japanese practice guidelines on osteoporosis was published. It has been updated several times, with most recent being full-scale 2011 edition and its abridged edition. The present provide information for managements of primary in postmenopausal women men over 50 years old, a summary evidence treatment secondary osteoporosis, prevention younger people.The Executive Summary is primarily based content One key changes revision criteria initiation pharmacological treatment,...
A novel estrogen receptor, receptor beta (ERbeta), has recently been cloned from a rat prostate cDNA library. In bone, which is an important target tissue of estrogen, ER alpha reported to be present preferentially in osteoblasts, but the mechanism action bone still not known. study, we examined expression ERbeta mRNA bone. Expression was evident primary osteoblastic cells isolated 1-day-old calvaria and osteosarcoma (ROS 17/2.8), its level higher than that mRNA. When were cultured for 28...
ABSTRACT A hollow-fiber membrane chamber (HFMC) was developed as an in situ cultivation device for environmental microorganisms. The HFMC system consists of 48 to 96 pieces porous connected with injectors. allows rapid exchange chemical compounds, thereby simulating a natural environment. Comparative analysis through the three types samples performed using this newly designed and conventional agar-based petri dish. results show that ratios novel phylotypes isolates, species-level...
The objective of this clinical trial was to examine the efficacy a supplement containing natural S-(-)equol, daidzein metabolite, in reducing menopausal symptoms.In multicenter, double-blind placebo-controlled trial, 160 equol nonproducing, postmenopausal Japanese women who experienced at least 1 hot flush/day were randomly assigned consume 10 mg/day S-(-)equol (n=77 women) or placebo (n=83 for 12 weeks. Participants completed standardized symptom checklist and rated five common menopause...
Abstract Estrogen deficiency caused by ovariectomy (OVX) results in a marked bone loss because of stimulated resorption. We have reported that OVX selectively stimulates B lymphopoiesis mouse marrow, which is somehow related to prevents both the increased and resorption estrogen deficiency. Raloxifene also has potent estrogenic activity for with minimal uterus. To examine effects raloxifene on resorption, mice were given either or subcutaneously 2–4 weeks using miniosmotic pump. Reduced...
Our previous questionnaire-based survey suggested that discontinuation of antiresorptive agents before tooth extraction may increase adverse events and disturb osteoporosis treatment without completely preventing osteonecrosis the jaw (O.N.J.). We also found little cooperation between physicians dentists in Japan. However, limitations our study included a doctors belonging to small clinics sample size. current aimed confirm results mainly academia.A structured questionnaire including 14 key...
Objectives:The authors conducted a randomized controlled trial to clarify the efficacy and safety of alendronate plus alfacalcidol versus alone in clinical setting.Research design methods:Eligible patients were postmenopausal women with severe osteoporosis who aged 70 years or older had several risk factors for incident fractures. The primary endpoint was prevention fractures, anti-fracture evaluated relation baseline serum 25(OH)D level.Results:A total 2164 (combination therapy)...
Equol, an active metabolite possessing estrogen-like activity, is produced by the action of intestinal flora on soy isoflavones. There increasing evidence regarding its efficacy in relief menopausal symptoms, suppression decreased bone mineral density, and lipid profile improvement. Only those with equol-producing capacity, however, seem to benefit. Thus, we examined relationship between equol producer status parameters associated lifestyle-related diseases women from their 20s 80s.This...
Objective: To examine changes in the bone and cardiovascular parameters tolerability middle-aged Japanese women taking equol supplement for a year. Design: This was prospective observational study. Subjects Setting: Participants were 74 receiving outpatient care at Hamasite Medical Clinic, Minato-ku, Tokyo, from 2013 to 2015. Interventions: received per oral equol-containing supplement, 10 mg/day. Outcome measures: The primary outcome measures percent after 1 year supplementation with equol....