A5073927730- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Estrogen and related hormone effects
- Sports injuries and prevention
- Bone health and osteoporosis research
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- Menopause: Health Impacts and Treatments
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Tendon Structure and Treatment
- Bone health and treatments
- Reproductive Biology and Fertility
- Quantum many-body systems
- Endometriosis Research and Treatment
- HER2/EGFR in Cancer Research
- Ovarian function and disorders
- Black Holes and Theoretical Physics
- Nerve Injury and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Osteoarthritis Treatment and Mechanisms
- Muscle Physiology and Disorders
Nagoya City University
2015-2025
Mizuho (Japan)
2017-2024
Kavli Institute for Theoretical Sciences
2021-2024
University of Chinese Academy of Sciences
2021-2024
RIKEN
2021-2024
Kyoto University
2014
University of Pittsburgh
2007-2012
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
2006-2011
University of Pittsburgh Medical Center
2009
Children's Hospital of Pittsburgh
2007-2008
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation fibrosis within muscle. In this study, we further explored potential role myostatin fibrosis, well its interaction with both transforming growth factor-β1 and decorin. We discovered stimulated fibroblast proliferation vitro induced differentiation into myofibroblasts. found expression, conversely, secretion C2C12 myoblasts. Decorin, small...
In this paper, we study Renyi and von Neumann entanglement entropy of excited states created by local operators in large-|$N$| (or large-central-charge) conformal field theories (CFTs). First point out that a naive expansion can break down for the entropy, while it does not entropy. This happens even free Yang–Mills theories. Next, analyze strongly coupled CFTs from both field-theoretic holographic viewpoints. We find state, produced operator, grows logarithmically under its time evolution...
Posterior and posteroinferior capsules in the shoulder joints of throwing athletes have been reported to be thicker than nonthrowing shoulders, this has a relationship glenohumeral internal rotation deficit (GIRD). However, stiffness these thickened not reported. Shear-wave ultrasound elastography is new technology that can measure tissue elasticity quantitatively.The posterior are stiffer as well shoulders baseball players their shoulders. The thickness inversely correlated with...
The objective of this clinical trial was to examine the efficacy a supplement containing natural S-(-)equol, daidzein metabolite, in reducing menopausal symptoms.In multicenter, double-blind placebo-controlled trial, 160 equol nonproducing, postmenopausal Japanese women who experienced at least 1 hot flush/day were randomly assigned consume 10 mg/day S-(-)equol (n=77 women) or placebo (n=83 for 12 weeks. Participants completed standardized symptom checklist and rated five common menopause...
Background Muscle contusions are the most common muscle injuries in sports medicine. Although these capable of healing, incomplete functional recovery often occurs. Hypothesis Suramin enhances healing by both stimulating regeneration and preventing fibrosis contused skeletal muscle. Study Design Controlled laboratory study. Methods In vitro: Myoblasts (C2C12 cells) muscle-derived stem cells (MDSCs) were cultured with suramin, potential suramin to induce their differentiation was evaluated....
Background: Muscle contusions are common muscle injuries. Although these injuries capable of healing, incomplete functional recovery often occurs. Muscle-derived stem cells (MDSCs) likely derived from blood vessel and have a multilineage differentiation potential. Purpose: The aims this study (1) to find optimal timing MDSC transplantation enhance healing by stimulating regeneration preventing scar tissue (fibrosis) formation after skeletal contusion injury, (2) investigate the role...
Background: It has been demonstrated that double-bundle reconstruction of the posterior cruciate ligament restores knee kinematics better than does single-bundle reconstruction. The objective this study was to identify tibial insertion site and related osseous landmarks help guide surgeons in performance an anatomical ligament. Methods: Twenty-one unpaired human cadaver knees were evaluated. geometric data surface features its bundles studied with macroscopic observation three-dimensional...
We numerically study the effect of spatial inhomogeneity on quantum information scrambling, a process spreading and locally hiding in many-body systems. As paradigmatic example, we consider chaotic Ising spin chain its inhomogeneous counterpart that is obtained by modulating Hamiltonian density. Specifically, so-called M\"obius sine-square deformations were previously studied context ($1+1$)-dimensional conformal field theories ($1+1$ d CFTs). In region where modulated energy density small,...
Background: Postoperative residual rotatory laxity remains despite improvement in surgical techniques for anterior cruciate ligament (ACL) reconstruction (ACLR). Purpose: To evaluate factors associated with pivot shift after ACLR by quantitative measurement of the before and surgery. Study Design: Case-control study; Level evidence, 3. Methods: A total 97 patients who underwent primary double-bundle between June 2016 March 2021 surgery to remove staples, at least 12 months follow-up...
The nonequilibrium process where the system does not evolve to featureless state, that without quantum properties, is one of new central objects in phenomena. In this paper, starting from short-range entangled state two-dimensional conformal field theories (2D CFTs), boundary with a regularization, we inhomogeneous Hamiltonians called Möbius/sine-square-deformed (SSD) ones. Regardless details CFTs considered during Möbius evolution, entanglement entropy exhibits periodic motion revival....
A bstract We explore non-equilibrium processes in two-dimensional conformal field theories (2d CFTs) due to the growth of operators induced by inhomogeneous and homogeneous Hamiltonians investigating time dependence partition function, energy density, entanglement entropy. The considered this paper are constructed out Lorentzian Euclidean evolution governed different Hamiltonians. effect ordering on dynamics so that we find a free boson CFT RCFTs, does not affect entropy, while holographic...
Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy, and embolization been proposed, but most appropriate should selected after considering risk of tumour recurrence complications. Endoscopic curettage (ESC) may a less invasive alternative for ABC treatment. We aimed describe use ESC ABCs report our clinical outcomes, including incidence...
Endoscopic curettage is considered applicable for the treatment of simple bone cysts with expectation that it might be less invasive than open curettage. In this study, we investigated efficacy endoscopic cysts. The goal was to investigate incidence cyst recurrence and healing after Moreover, complications functionality at final follow-up were evaluated.From 2003 2014, 37 patients underwent Twenty-four male 13 female, a mean age 14.7 years. performed support an arthroscope via 7-8 mm holes...
Background Misplacement of the bone tunnels is one main causes graft failure anterior cruciate ligament surgery. Hypothesis Anatomic tunnel placement in surgery reconstruction will lead to improved outcomes, including biological ingrowth and biomechanical properties, when compared with nonanatomic placement. Study Design Controlled laboratory study. Methods Anterior reconstructions were performed on 3 different groups goats (1 anatomic group 2 groups, 10 each group). For knees, knees used...
Abstract Aim: To examine whether low‐dose and short‐term estrogen‐replacement therapy (ERT) plus selective serotonin re‐uptake inhibitor (SSRI) treatment is effective or not in the of climacteric disorders, hot flashes depressive symptoms, oophorectomized women. Method: Forty‐two women with symptoms were assigned randomly to two groups. We examined efficacy rates particularly 21 on ERT (conjugated equine estrogens [CEE] 0.3125 mg/day) (CEE SSRI (fluvoxamine 50 treated for 8 weeks. used...
Few reports about clinical experience in arthroscopy of finger joints exist. Furthermore, little attention has been given to arthroscopic synovectomy rheumatoid fingers. Herein, we describe our with metacarpophalangeal (MCP) and proximal interphalangeal (PIP) patients arthritis.Arthroscopic was performed 45 (18 MCP joints, 26 PIP 1 thumb joint) 23 arthritis. All procedures were on an outpatient basis under regional anesthesia. The diameter the arthroscope for small 1.5 mm, a mini shaver...
Abstract Introduction Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, aberrant GLS production been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. The human gene promoter contains at least seven consensus binding sites for DNA protein Sp1. Here we examined whether Sp1 is necessary RA. We also studied effects inhibitor mithramycin on RA fibroblast-like synoviocytes (FLSs). Methods FLSs from patients were treated with...
Soft tissue coverage around the knee has persisted as a challenge for plastic and reconstructive surgeons. The distally-based anterolateral thigh flap is often used coverage. Nevertheless, few anatomical studies have investigated retrograde vascular pedicle. This report clarifies anatomy of connection between descending branch lateral circumflex femoral artery superior genicular artery. study examined 38 lower limbs from cadavers recorded numbers locations perforating vessels. Proximal...