A5038252858- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Orthopaedic implants and arthroplasty
- Musculoskeletal synovial abnormalities and treatments
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Orthopedic Infections and Treatments
- Chemotherapy-related skin toxicity
- Neuroblastoma Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Shoulder Injury and Treatment
- Virus-based gene therapy research
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Hip and Femur Fractures
- Bone fractures and treatments
- Hematological disorders and diagnostics
- Tumors and Oncological Cases
- Shoulder and Clavicle Injuries
Mizuho (Japan)
2016-2024
Nagoya City University
2014-2024
Istituto Ortopedico Rizzoli
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
National Cancer Center Hospital East
2023-2024
Tosei General Hospital
2016-2022
Kanazawa University
2017-2021
ORCID
2020
Background Reconstruction of the proximal humerus in children who undergo bone tumor resection is challenging because patients’ small size and possible limb length discrepancy at end skeletal growth due to loss physis. There are several options for reconstruction children, such as clavicula pro humero, free vascularized fibula grafting, massive osteoarticular allografting, endoprostheses, allograft-prosthesis composites, but no consensus exists on best method reconstruction. Resurfaced...
Use of an implant is one the risk factors for surgical site infection (SSI) after malignant bone tumor resection. We developed a new technique coating titanium surfaces with iodine to prevent infection. In this retrospective study, we investigated SSI resection and evaluate efficacy iodine-coated implants preventing SSI.Data from 302 patients tumors who underwent reconstruction were reviewed. Univariate analyses performed, followed by multivariate analysis identify based on treatment...
Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy, and embolization been proposed, but most appropriate should selected after considering risk of tumour recurrence complications. Endoscopic curettage (ESC) may a less invasive alternative for ABC treatment. We aimed describe use ESC ABCs report our clinical outcomes, including incidence...
Endoscopic curettage is considered applicable for the treatment of simple bone cysts with expectation that it might be less invasive than open curettage. In this study, we investigated efficacy endoscopic cysts. The goal was to investigate incidence cyst recurrence and healing after Moreover, complications functionality at final follow-up were evaluated.From 2003 2014, 37 patients underwent Twenty-four male 13 female, a mean age 14.7 years. performed support an arthroscope via 7-8 mm holes...
ABSTRACT Despite the importance of genetic testing for risk assessment and treatment in breast cancer, prognostic impact germline pathogenic variants (PVs), especially Asian populations, is unclear. We assessed PVs patients with early‐stage cancer. This study included 7278 Japanese multihospital registry patients. ATM , BRCA1 BRCA2 CDH1 CHEK2 NBN NF1 PALB2 PTEN STK11 TP53 were evaluated. PV non‐PV carriers matched by age, histology, stage. Associations between survival assessed. The primary...
Abstract Soft tissue sarcomas (STSs) are a rare cancer type. Almost half unresponsive to multi‐pronged treatment and might therefore benefit from biologically targeted therapy. An emerging target is glycogen synthase kinase (GSK)3β, which implicated in various diseases including cancer. Here, we investigated the expression, activity putative pathological role of GSK3β synovial sarcoma fibrosarcoma, comprising majority STS that encountered orthopedics. Expression active form (tyrosine...
Abstract Background Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone soft tissue tumors that involve a major long bone. do not require bank, they carry no risk of viral bacterial disease transmission, associated smaller immunologic response, have better shape size match to the site in which implanted. However, disadvantages as well; it is possible assess margins...
Aims Low-grade central osteosarcoma (LGCOS), a rare type of osteosarcoma, often has misleading radiological and pathological features that overlap with those other bone tumours, thereby complicating diagnosis treatment. We aimed to analyze the clinical, radiological, patients LGCOS, focus on diagnosis, treatment, outcomes. Methods retrospectively analyzed medical records 49 LGCOS (Broder’s grade 1 2) treated between January 1985 December 2017 in single institute. examined presence malignant...
Abstract Surgical resection is the only treatment for chondrosarcomas, because of their resistance to chemotherapy and radiotherapy; therefore, additional strategies are crucial treat chondrosarcomas. Peroxisome proliferator‐activated receptor gamma ( PPAR γ ) a ligand‐activated transcription factor, which has been reported as possible therapeutic target in certain malignancies including In this study, we demonstrated that nonsteroidal anti‐inflammatory drug, zaltoprofen, could induce...
Osteosarcoma is the most frequent type of primary bone tumor in children and adolescents, thus care for patients with malignant osteosarcoma strongly required. The roles small extracellular vesicles (SEVs) enhancing metastases have been demonstrated multiple tumors, but they are still poorly understood osteosarcoma. Hence, this study investigated effects SEVs on progression microenvironment mice patients. In an orthotopic implantation study, we found that osteosarcoma-derived had potential...
Trabectedin is used as a treatment for advanced-stage soft tissue sarcomas (STSs), particularly liposarcoma and leiomyosarcoma. Aside from its direct effect on tumor cells, trabectedin can affect the immune system in microenvironment. This study aimed to evaluate whether inflammatory biomarkers predict efficacy STSs.
Background Proximal femur reconstruction after bone tumor resection in children is a demanding surgery for orthopaedic oncologists because of the small size and possible limb-length discrepancy at end skeletal growth owing to physis loss. The most commonly used types proximal are modular prostheses allograft-prosthesis composites. To our knowledge, there no previous studies comparing outcomes prosthesis composite with primary tumors. Questions/purposes (1) What was cumulative incidence...
Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed efficacy concomitant radiotherapy, hyperthermia, (RHC) for neoadjuvant treatment malignant soft tissue sarcoma (STS). From 1994 2013, performed RHC in 150 patients. This study was limited 60 patients using following exclusion criteria: salvage recurrence or unplanned excision, trunk location, metastasis at initiation, non-STS, no definitive surgery. As a control...
There are several options for biological reconstruction after bone tumor resection. If the invades an epiphysis, is far more complicated because there no option to restore large joint cartilage using currently available medical techniques. Frozen autograft with liquid nitrogen has been used as recycled autologous graft and purpose of present study was assess outcome grafted in osteoarticular frozen autografts treatment patients soft-tissue sarcoma. We have treated 27 cases resection...