A5025137772- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine regulation and behavior
- Nanoplatforms for cancer theranostics
- Neuroscience of respiration and sleep
- Lysosomal Storage Disorders Research
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
- Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Vascular Tumors and Angiosarcomas
- Growth Hormone and Insulin-like Growth Factors
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Infant Health and Development
- Rheumatoid Arthritis Research and Therapies
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
Kanazawa University
2016-2025
Jikei University School of Medicine
2011-2025
Japanese Red Cross Kanazawa Hospital
2020-2024
Tokyo National Hospital
2020-2024
AntiCancer (United States)
2018-2023
University of California, San Diego
2018-2023
National Hospital Organization
2010-2023
Kanazawa Medical Center
2023
Kyushu University
2023
Kumamoto University
2022
Female mice form an olfactory memory of male pheromones at mating; exposure to the a strange after that mating will block pregnancy. The formation this is mediated by accessory system, in which increase norepinephrine reduces inhibitory transmission γ-aminobutyric acid from granule cells mitral cells. This study shows activation mGluR2, metabotropic glutamate receptor suppresses inhibition cells, permits specific without occurrence infusion mGluR2 agonists into female's bulb. faithfully...
A detailed secretory profile of oxytocin during suckling and parturition was determined in unanaesthetized freely moving rats. Ten pups were reunited with their mothers after 12-15 h separation. Unless the milk-ejection reflex occurred, there no difference serum levels before separation either four or five, nine ten pups. Serum increased abruptly by 50.1 +/- 4.2 (S.E.M.) pmol/l (n = 9) at milk ejection, declined rapidly a half-life about 1.5 min. The peak concentration blood each ejection...
1. Experiments were undertaken to provide evidence for the existence of a circuit neuronal interconnections between supraoptic nucleus (SON), ventral anteroventral third ventricular region (including organum vasculosum lamina terminalis; AV3V) and median preoptic (MnPO), determine importance these connections in osmotic control activity SON. Extracellular recordings made urethane‐anaesthetized male rat from neurones one three sites, while other two sites electrically stimulated. 2. During...
Recently, manufactured nano/microparticles such as fullerenes (C60), carbon black (CB) and ceramic fiber are being widely used because of their desirable properties in industrial, medical cosmetic fields. However, there few data on these particles mammalian mutagenesis carcinogenesis. To examine genotoxic effects by C60, CB kaolin, an vitro micronuclei (MN) test was conducted with human lung cancer cell line, A549 cells. In addition, DNA damage mutations were analyzed vivo assay systems...
Synovial sarcoma (SS) is a recalcitrant neoplasm with low chemosensitivity. We recently reported that recombinant methioninase (rMETase) inhibited SS growth in patient-derived orthotopic xenograft (PDOX) mouse model and was more effective when administered combination the first-line drug doxorubicin (DOX). Caffeine enhances efficacy of anticancer drugs by overcoming drug-induced cell-cycle arrest increasing subsequent apoptosis. Here, we determined oral (o-rMETase) combined caffeine on an...
To determine uroplakin III expression, potential etiologic factors, biological behavior, and treatment response of transitional cell carcinoma (TCC) in the abdominal wall (ABWTCC) dogs.Retrospective case series.24 dogs with TCC urinary tract that also had histopathologic confirmation ABWTCC.Medical records, histologic slides, radiographs, ultrasonographic images ABWTCC between July 1, 1985, December 31, 2010, were reviewed. In available tissue specimens, immunohistochemistry was used to...
Mucopolysaccharidosis type II (MPS II) is a neuropathic lysosomal storage disorder caused by deficiency of iduronate-2-sulfatase (IDS), which leads to the accumulation glycosaminoglycans (GAGs). We demonstrated that biochemical alterations in brains MPS mice are not corrected bone marrow transplantation (BMT) or enzyme replacement therapy, although BMT has been shown be effective for other neurodegenerative MPSs, such as Hurler syndrome. In this study, we lentiviral isogeneic hematopoietic...
In advanced non-small-cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) have been reported a better treatment outcome on primary lesions, however, the therapeutic effect bone metastases has not clarified. This study investigates of ICIs in NSCLC.The data patients with NSCLC, treated from 2016 to 2019 at our hospital, were analyzed. The effects and metastatic concomitant use modifying agents (BMA), outcomes, frequency immune-related adverse events (irAEs) skeletal-related (SREs)...
Prolactin, GH, TSH, adrenaline and noradrenaline responses to the stress of immobilization were compared between lactating non-lactating dioestrous rats. The concentrations GH in plasma reduced a similar degree by rats, TSH levels unchanged both groups. increases induced significantly smaller than Immobilization caused marked increase prolactin rats but no These changes may help save energy maintain milk production during period lactation.
Cholinergic arousal system plays an important role in the maintenance of consciousness. The authors investigated whether intrabasalis injection orexin-A or orexin-B and electrically stimulated pedunculopontine tegmentum nuclei (PPTg: origin cholinergic ascending pathways) may alter acetylcholine efflux electroencephalographic activity somatosensory cortex relation to orexinergic isoflurane-anesthetized rats.Either (10, 30, 100 pmol) (n = 6 each) was injected into basal forebrain while...
When slices of ovine lutea’ tissue were perfused with medium containing luteinizing hormone (LH), the output progesterone was increased significantly (P < 0.01) in eleven twelve experiments. However, addition LH to did not influence luteal cell membrane potential. The 47 mM potassium resulted and depolarization within 2 min. Progesterone decreased approximate pretreatment levels min return normal perfusion medium. High further from stimulated LH. Perfusion sodium-free also min, which...
Pancreatic cancer is a recalcitrant disease. Gemcitabine (GEM) the most widely-used first-line therapy for pancreatic cancer, but patients eventually fail. Transformative necessary to significantly improve outcome of patients. Tumors have an elevated requirement methionine and are susceptible restriction. The present study used patient-derived orthotopic xenograft (PDOX) nude mouse model determine efficacy recombinant methioninase (rMETase) effect restriction thereby overcome GEM-resistance....
Background/Aim: Osteosarcoma is a recalcitrant neoplasm which occurs predominantly in adolescents and young adults. Recently, using patient-derived orthotopic xenograft (PDOX) model of malignant soft-tissue sarcoma (STS), we showed that oral recombinant methioninase (o-rMETase), combination with caffeine, was more efficacious than o-rMETase alone inhibiting STS tumor growth. In the present report, determined efficacy combined caffeine on cisplatinum (CDDP)-resistant osteosarcoma PDOX model....
Background/Aim: Liver metastasis in colorectal-cancer is a recalcitrant disease. To develop precision individualized therapy of this disease, we developed patient-derived orthotopic xenograft (PDOX) model liver metastasis. In the present report, evaluated efficacy oral recombinant methioninase (o-rMETase) combination with 5-fluorouracil (5-FU) and oxaliplatinum (OXA) on PDOX mouse model. Materials Methods: Colorectal-cancer models were randomized into three groups seven mice. Group 1,...
Immune checkpoint inhibitors (ICIs) can significantly prolong the survival of patients with advanced non-small-cell lung cancer (NSCLC); however, few studies on therapeutic effects ICIs bone metastases were performed.This retrospective study aimed to investigate and determine predictors favorable ICI response prognosis in 55 NSCLC who initiated treatment between 2016 2019, a mean follow-up period 23.2 months. Patients classified into responders (complete or partial response) non-responders...
Abstract Polymyalgia rheumatica (PMR) is a chronic inflammatory disease characterized by arthralgia and myalgia of the shoulder hip girdles, fever. PMR linked to autoimmune diseases autoinflammatory disorders. Exome sequencing has revealed roles rare variants in some diseases. Causative genes for monogenic disorders might be candidate selective exome analysis PMR. We investigated coding boundary regions was performed analyze deleterious genes, frequencies alleles were compared with those...
Pompe disease (PD) is a lysosomal disorder caused by acid α-glucosidase (GAA) deficiency. Progressive muscular weakness the major symptom of PD, and enzyme replacement therapy can improve clinical outcome. However, to achieve better outcome, alternative therapeutic strategies are being investigated, including gene pharmacological chaperones. We previously used lentiviral vector-mediated GAA transfer in PD patient-specific induced pluripotent stem cells. Some efficacy was observed, although...
Epiphyseal-preservation surgery for osteosarcoma is an alternative method which has been indicated carefully to selected patients. The tumor-devitalised autograft treated with liquid nitrogen procedure one of the biological reconstruction reconstruct defect after tumor excision. limb length discrepancy usually appeared in children their growth limb-sparing surgery. This study was aimed investigated residual epiphysis following epiphyseal-preservation childhood around knee joint.We...