A5082343932- Pain Mechanisms and Treatments
- TGF-β signaling in diseases
- Nerve injury and regeneration
- Pressure Ulcer Prevention and Management
- Biochemical and Molecular Research
- Anesthesia and Neurotoxicity Research
- Trypanosoma species research and implications
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Bone Metabolism and Diseases
- Connective tissue disorders research
- Kruppel-like factors research
- Airway Management and Intubation Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroendocrine regulation and behavior
- Nitric Oxide and Endothelin Effects
- Respiratory Support and Mechanisms
- Biochemical effects in animals
- Simulation-Based Education in Healthcare
- Memory and Neural Mechanisms
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Antimicrobial Peptides and Activities
Yamagata University
2022-2025
Tokyo University of Science
2024
Hokkaido University
2020-2024
Kindai University
2024
Komatsu University
2022
Sapporo University
2020
Middlebury College
2020
Ehime University
2009-2018
University of Fukui
1998-2015
Saitama Medical University
2014
Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of creating constitutively active forms (SmadDVD). Transcriptional activity Smad9DVD was lower than that Smad1DVD or Smad5DVD, even though all three SmadDVDs associated with Smad4 bound to target DNA. The linker region sufficient reduce transcriptional activity. expression increased activation BMP signaling, similar inhibitory...
Cholinergic arousal system plays an important role in the maintenance of consciousness. The authors investigated whether intrabasalis injection orexin-A or orexin-B and electrically stimulated pedunculopontine tegmentum nuclei (PPTg: origin cholinergic ascending pathways) may alter acetylcholine efflux electroencephalographic activity somatosensory cortex relation to orexinergic isoflurane-anesthetized rats.Either (10, 30, 100 pmol) (n = 6 each) was injected into basal forebrain while...
Burn injury causes nociceptive behaviors, and inflammation-related pathologic pain can lead to glial cell activation. This study tested the hypothesis that burn activates cells, cannabinoid receptor 1 (CB1R) antagonist, AM251, will decrease pain.Anesthetized rats received 0.75-cm third-degree on dorsal hind paw. Vehicle or AM251 30 μg intrathecally (older rats, n=6 per group) or, either vehicle, 0.1 1.0 mg/kg intraperitoneally (younger group), started immediate postburn, was administered for...
The present study was designed to investigate a possible role for ovarian steroids in the regulation of rat uterine oxytocin receptor (OTR) mRNA expression before labour. By using competitive RT-PCR system, we have previously reported that parturition associated with high levels OTR all animals examined. On other hand, near term, some rats showed while others did not. We therefore examined changes and during prostaglandin F(2)(alpha) (PGF(2)(alpha))-induced parturition; paradigm adopted...
Malaria parasite transmission to humans is initiated by the inoculation of Plasmodium sporozoites into skin mosquitoes. Sporozoites develop within mosquito midgut oocysts, first invade salivary glands mosquitoes, and finally infect hepatocytes in mammals. The apical structure conserved with infective forms other apicomplexan parasites that have secretory organelles, such as rhoptries micronemes. Because some rhoptry proteins are crucial for merozoite infection erythrocytes, we examined roles...
The aging process in the elderly results heightened skin fragility associated with various disorders, including pressure ulcers (PUs). Despite high incidence of PUs population, there is a limited body research specifically examining impact on development ulcers. Therefore, investigating age-related physiological abnormalities essential to elucidate pathogenesis PUs. Ischemia-reperfusion (I/R) injury and subsequent oxidative stress caused by reactive oxygen species (ROS) play roles early...
The involvement of activin and follistatin, an activin-binding protein, in endochondral bone development was examined by sc implantation demineralized matrix rats. Immunoreactive follistatin localized proliferating chondrocytes round osteoblasts, whereas it not detected hypertrophic osteoblasts surrounding marrow. Western blot analysis also revealed that immunoreactive higher during the initial stages chondrogenesis (day 5) osteogenesis (days 11 14) lower conversion from cartilage to 9)....
While some intracellular bacterial and viral proteins secreted into host cell possess ubiquitin ligase (E3) activity for their profit, it has not been reported whether parasites secrete such molecules. We identified a gene that encodes protein containing secretory signal peptide RING finger domain in the protozoan parasite, Trypanosoma cruzi. This was specific to T. cruzi designated spring (secretory with domain). An vitro ubiquitination assay showed SPRING possessed E3 domain-dependent...
We have studied immunolocalization of activin receptors in the central nervous system using polyclonal antibodies (IgG) to type I (50-55 kDa, ActRI), II (70-75 ActRII) or a subtype known as IIB (ActRIIB) activin. A total 7 antisera rat was generated, i.e. 3 kinds extracellular domain (ActRI(81-89), ActRII(91-100), ActRIIB(90-99)) and 4 kinase (ActRI(323-333), ActRII(307-319), ActRII(407-420) ActRIIB(306-319)). The region aa 407-420 ActRII is identical with that ActRIIB. At first, we...
The cholinergic arousal systems are known to critically regulate the state of consciousness. aim this study was determine effect isoflurane on inhibitory or excitatory neurotransmitters efflux in important nuclei within system using vivo intracerebral microdialysis.The glutamate, gamma-aminobutyric acid (GABA), acetylcholine posterior hypothalamus (PH), basal forebrain (BF), and somatosensory cortex (S1BF) rats detected microdialysis under an awake condition at 0.5-2.0 minimum alveolar...
<h3>Background:</h3> Arachidonic acid (ARA) and docosahexaenoic (DHA) are important components of phospholipids cell membranes. There has, however, been no clinical report on the direct effects ARA DHA coronary circulation. <h3>Objective:</h3> To evaluate circulation using measurement flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). <h3>Methods:</h3> A double-blind, placebo-matched study 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to...
Background CpG oligodeoxynucleotides (ODNs), resembling bacterial DNA, are currently tested in clinical trials as vaccine adjuvants. They have the nuclease-resistant phosphorothioate bond; immune responses elicited differ according to ODN sequence and vaccination method. To develop a that can induce plasmacytoid dendritic cell (pDC)-mediated TH1 immunity through mucosa, we constructed phosphodiester G9.1 comprising one palindromic motif with unique polyguanosine-runs allows degradation...
We synthesized ridaifen-B boron dipyrromethene ( RID-B-BODIPY ) using 2-methyl-6-nitro benzoic anhydride (MNBA)-mediated dehydration condensation reaction between amino alkyl-tethered RID and BODIPY FL. Comparative experiments dicyclohexylcarbodiimide (DCC) MNBA for their coupling reactions demonstrated that is an effective reagent amines A cell staining study with showed intracellular localization of FL fluorescence, attributed to the RID-B structure, indicating successful development a...
ABSTRACT Death receptor‐mediated host cell apoptosis, a defense strategy for elimination by the immune system of parasite‐infected cells, is inhibited Trypanosoma cruzi , causative agent Chagas' disease. It has previously been reported us that, in infected T. upregulates and exploits cFLIP L mammalian inhibitor death receptor signaling. Here it shown that ubiquitination L, leading to proteasomal degradation, cells. The extent expression Itch, protein thought be an ubiquitin ligase was found...
This paper describes a next-generation nursing education simulator, the endotracheal suctioning training environment simulator (ESTE-SIM), which is capable of interactively reproducing vital reactions. With spread home treatment, care providers who have received certain level should be increased, not limited to conventional health-care professionals. A great gap exists between simulations under restricted conditions that been practiced in and those actual clinical site, thus creating burden...